Reported here is the thermotropic behavior of cationic gemini/phospholipid/DNA complexes investigated by synchrotron X-ray diffraction. At low temperature, DNA forms rectangular columnar superlattices between interdigitated bilayers. At temperatures above the lipid main phase transition, the transbilayer DNA ordering is partly preserved and DNA arranged into a simple rectangular lattice. This is the first time that such a predicted superstructure is observed in the liquid-crystalline phase of cationic lipid/DNA complexes.
Observation of a rectangular DNA superlattice in the liquid-crystalline phase of cationic lipid/DNA complexes / Caracciolo, Giulio; Pozzi, Daniela; Caminiti, Ruggero; Mancini, G; Luciani, P; Amenitsch, H.. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - 129:(2007), pp. 10092-10093. [10.1021/ja073890s]
Observation of a rectangular DNA superlattice in the liquid-crystalline phase of cationic lipid/DNA complexes
CARACCIOLO, Giulio;POZZI, DANIELA;CAMINITI, Ruggero;
2007
Abstract
Reported here is the thermotropic behavior of cationic gemini/phospholipid/DNA complexes investigated by synchrotron X-ray diffraction. At low temperature, DNA forms rectangular columnar superlattices between interdigitated bilayers. At temperatures above the lipid main phase transition, the transbilayer DNA ordering is partly preserved and DNA arranged into a simple rectangular lattice. This is the first time that such a predicted superstructure is observed in the liquid-crystalline phase of cationic lipid/DNA complexes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
