It has been proposed that S100B can be a marker for several pathological conditions including brain traumas, blood-brain barrier disruption, and ischemia. Because the hypothalamo-pituitary-adrenal axis is activated in these conditions, we investigated the role of glucocorticoids in the effects of stress on serum S100B. Restraint stress increased S100B levels in control and in adrenalectomized but not in corticosterone-injected rats. Adrenalectomy did not alter basal S100B. These results indicate a glucocorticoid-independent relationship between stress and S100B. (C) 2004 Elsevier B.V. All rights reserved.

Relationship between stress and circulating levels of S100B protein / Scaccianoce, Sergio; DEL BIANCO, Paola; Pannitteri, Gaetano; Passarelli, Francesca. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 1004:1-2(2004), pp. 208-211. [10.1016/j.brainres.2004.01.028]

Relationship between stress and circulating levels of S100B protein

SCACCIANOCE, Sergio;DEL BIANCO, Paola;PANNITTERI, Gaetano;PASSARELLI, Francesca
2004

Abstract

It has been proposed that S100B can be a marker for several pathological conditions including brain traumas, blood-brain barrier disruption, and ischemia. Because the hypothalamo-pituitary-adrenal axis is activated in these conditions, we investigated the role of glucocorticoids in the effects of stress on serum S100B. Restraint stress increased S100B levels in control and in adrenalectomized but not in corticosterone-injected rats. Adrenalectomy did not alter basal S100B. These results indicate a glucocorticoid-independent relationship between stress and S100B. (C) 2004 Elsevier B.V. All rights reserved.
2004
endocrine and autonomic regulation; glucocorticoid; neuroendocrine regulation: other; s100b protein; stress
01 Pubblicazione su rivista::01a Articolo in rivista
Relationship between stress and circulating levels of S100B protein / Scaccianoce, Sergio; DEL BIANCO, Paola; Pannitteri, Gaetano; Passarelli, Francesca. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 1004:1-2(2004), pp. 208-211. [10.1016/j.brainres.2004.01.028]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/233400
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 72
  • ???jsp.display-item.citation.isi??? 66
social impact