A practical and straightforward protocol for the preparation of a solution-phase library of acrylonitrile scaffolds is reported. Target compounds were obtained in high yield, stereoselectivity, and purity by two simple and practical steps from cyanoacetic acid. Moreover, our study proposes a synthetic approach starting from the constructed library to obtain three-membered heterocycles.
Parallel solution-phase synthesis of acrylonitrile scaffolds carrying L-alpha-amino acidic or D-glycosyl residues / Fioravanti, Stefania; Pellacani, Lucio; Tardella, Paolo Antonio; Morreale, Alberto; DEL SIGNORE, Giuseppe. - In: JOURNAL OF COMBINATORIAL CHEMISTRY. - ISSN 1520-4766. - STAMPA. - 8:(2006), pp. 808-811. [10.1021/cc060029k]
Parallel solution-phase synthesis of acrylonitrile scaffolds carrying L-alpha-amino acidic or D-glycosyl residues
FIORAVANTI, Stefania;PELLACANI, Lucio;TARDELLA, Paolo Antonio;MORREALE, Alberto;DEL SIGNORE, GIUSEPPE
2006
Abstract
A practical and straightforward protocol for the preparation of a solution-phase library of acrylonitrile scaffolds is reported. Target compounds were obtained in high yield, stereoselectivity, and purity by two simple and practical steps from cyanoacetic acid. Moreover, our study proposes a synthetic approach starting from the constructed library to obtain three-membered heterocycles.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
