Dynamic HPLC on enantioselective stationary phases has become a well-established technique to investigate chiral molecules with internal motions that result in stereoinversion and occur on the time scale of the separation process. Kinetic parameters for the on-column interconversion phenomena can be extracted from experimental peak profiles by computer simulation or by direct calculation methods. The technique has been used in a wide range of temperatures and is complementary in scope to dynamic NMR spectroscopy.

Dynamic HPLC on chiral stationary phases: a powerful tool for the investigation of stereomutation processes / D'Acquarica, Ilaria; Gasparrini, Francesco; Pierini, Marco; Villani, Claudio; G., Zappia. - In: JOURNAL OF SEPARATION SCIENCE. - ISSN 1615-9306. - STAMPA. - 29:(2006), pp. 1508-1516. [10.1002/jssc.200600129]

Dynamic HPLC on chiral stationary phases: a powerful tool for the investigation of stereomutation processes

D'ACQUARICA, Ilaria;GASPARRINI, Francesco;PIERINI, MARCO;VILLANI, Claudio;
2006

Abstract

Dynamic HPLC on enantioselective stationary phases has become a well-established technique to investigate chiral molecules with internal motions that result in stereoinversion and occur on the time scale of the separation process. Kinetic parameters for the on-column interconversion phenomena can be extracted from experimental peak profiles by computer simulation or by direct calculation methods. The technique has been used in a wide range of temperatures and is complementary in scope to dynamic NMR spectroscopy.
2006
01 Pubblicazione su rivista::01a Articolo in rivista
Dynamic HPLC on chiral stationary phases: a powerful tool for the investigation of stereomutation processes / D'Acquarica, Ilaria; Gasparrini, Francesco; Pierini, Marco; Villani, Claudio; G., Zappia. - In: JOURNAL OF SEPARATION SCIENCE. - ISSN 1615-9306. - STAMPA. - 29:(2006), pp. 1508-1516. [10.1002/jssc.200600129]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/232991
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