The invenlion relates to 17a-(5-hydroxy-C5-hydrocarby])-l,3,5(10)-estratrien-3,17p-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them. In particular, the invention relates to estradiol 17a-(5-hydroxypenlyn-l-yl (derivatives and 3-esters, 5'-esters and 3,5'-diesters thereof and to a process for the preparation thereof by reaction of 3-OR-protected estrone with an alkali metal derivative of OR-protected 5-pentynol, followed by 3-, 5-'or 3,5'-esterification.

17-Alpha-substituted derivatives of estradiol with wound-healing activity / Ashcroft, G; Brufani, M; Ceccacci, Francesca; FARINA P., M; Filocamo, Luigi; Garofalo, B; Joudioux, R; Maggi, A; MARINI BETTOLO, Rinaldo; Migneco, Luisa Maria. - (2007).

17-Alpha-substituted derivatives of estradiol with wound-healing activity

CECCACCI, FRANCESCA;FILOCAMO, Luigi;MARINI BETTOLO, Rinaldo;MIGNECO, Luisa Maria
2007

Abstract

The invenlion relates to 17a-(5-hydroxy-C5-hydrocarby])-l,3,5(10)-estratrien-3,17p-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them. In particular, the invention relates to estradiol 17a-(5-hydroxypenlyn-l-yl (derivatives and 3-esters, 5'-esters and 3,5'-diesters thereof and to a process for the preparation thereof by reaction of 3-OR-protected estrone with an alkali metal derivative of OR-protected 5-pentynol, followed by 3-, 5-'or 3,5'-esterification.
2007
05 Brevetto::05a Brevetto
17-Alpha-substituted derivatives of estradiol with wound-healing activity / Ashcroft, G; Brufani, M; Ceccacci, Francesca; FARINA P., M; Filocamo, Luigi; Garofalo, B; Joudioux, R; Maggi, A; MARINI BETTOLO, Rinaldo; Migneco, Luisa Maria. - (2007).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/230714
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