The aim of the present review is to summarize integrated neurochemical, morphological and neurobehavioral evidence, in particular from our laboratory, which emphasize the short- and long-term consequences of prenatal exposure to the cannabinoid receptor agonist WIN55,212-2 on rat glutamate transmission and cognitive functions. The results obtained provide evidence that maternal exposure to WIN55,212-2 induces an impairment of cognitive capacities in the offspring. This impairment is associated with alterations of cortical and hippocampal glutamate outflow, cortical neuron morphology and hippocampal long-term potentiation. These findings are in line with clinical data showing that the consumption of marijuana by women during pregnancy has negative consequences on the cognitive functions of their children. Thus, although it is difficult and sometimes misleading to extrapolate findings obtained from animal models to humans, the possibility that an alteration of glutamate transmission might underlie, at least in part, some of the cognitive deficits affecting the offspring of marijuana users, is supported.

Short- and long-term consequences of prenatal exposure to the cannabinoid agonist WIN55,212-2 on rat glutamate transmission and cognitive functions / Luca, Ferraro; M. c., Tomasini; S., Beggiato; Gaetani, Silvana; T., Cassano; Cuomo, Vincenzo; S., Amoroso; S., Tanganelli; T., Antonelli. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - STAMPA. - 116:8(2009), pp. 1017-1027. (Intervento presentato al convegno International Conference on Brain Plasticity, Aging and Neuropsychiatric Disorders tenutosi a Madrid, SPAIN nel MAY 13-14, 2008) [10.1007/s00702-009-0230-0].

Short- and long-term consequences of prenatal exposure to the cannabinoid agonist WIN55,212-2 on rat glutamate transmission and cognitive functions

GAETANI, SILVANA;CUOMO, VINCENZO;
2009

Abstract

The aim of the present review is to summarize integrated neurochemical, morphological and neurobehavioral evidence, in particular from our laboratory, which emphasize the short- and long-term consequences of prenatal exposure to the cannabinoid receptor agonist WIN55,212-2 on rat glutamate transmission and cognitive functions. The results obtained provide evidence that maternal exposure to WIN55,212-2 induces an impairment of cognitive capacities in the offspring. This impairment is associated with alterations of cortical and hippocampal glutamate outflow, cortical neuron morphology and hippocampal long-term potentiation. These findings are in line with clinical data showing that the consumption of marijuana by women during pregnancy has negative consequences on the cognitive functions of their children. Thus, although it is difficult and sometimes misleading to extrapolate findings obtained from animal models to humans, the possibility that an alteration of glutamate transmission might underlie, at least in part, some of the cognitive deficits affecting the offspring of marijuana users, is supported.
2009
passive avoidance and emotional reactivity; basal and k+-evoked glutamate levels; map2 immunoreactivity; basal and k(+)-evoked glutamate levels; maternal marijuana consumption; ltp
01 Pubblicazione su rivista::01a Articolo in rivista
Short- and long-term consequences of prenatal exposure to the cannabinoid agonist WIN55,212-2 on rat glutamate transmission and cognitive functions / Luca, Ferraro; M. c., Tomasini; S., Beggiato; Gaetani, Silvana; T., Cassano; Cuomo, Vincenzo; S., Amoroso; S., Tanganelli; T., Antonelli. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - STAMPA. - 116:8(2009), pp. 1017-1027. (Intervento presentato al convegno International Conference on Brain Plasticity, Aging and Neuropsychiatric Disorders tenutosi a Madrid, SPAIN nel MAY 13-14, 2008) [10.1007/s00702-009-0230-0].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/230551
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