Background: The prevalence of venous thrombosis (VT) in children with solid tumor and the role of different risk factors are not defined yet. Aim: A cross-sectional observational study was conducted to evaluate the prevalence of both symptomatic and asymptomatic catheter-associated thrombosis events in children affected with different solid tumors. Methods: Patients with a solid tumor, admitted as day-care, were consecutively enrolled over a period of 10 months. All of them had a central venous line. Physical examination, D-dimer serum tests, and eco-color-Doppler ultrasonography were performed once at any time before catheter removal. Results: Forty-two patients (14 females and 28 males)-mean age 115 months-were evaluated. Five of the 42 patients (12%) had VT. In 4 of these, VT was catheter-related: 3 asymptomatic and I symptomatic. In the last patient, VT was clinically symptomatic and not catheter related. Patients with longer duration of catheter insertion presented with a higher rate of VT (P = 0.05). Moreover, patients affected with neuroblastoma showed a higher rate of VT than the others with different solid tumors (P < 0.05). Conclusions: VT was visualized by echo-color-Doppler ultrasonography in 12% of the patients; it was asymptomatic in 7%. In our small series, VT was related to neuroblastoma disease and a longer duration of catheter insertion. Prospective and multicentric studies are required to select risk factors for VT in children with solid tumors.

Venous thrombosis in children with solid tumors / Schiavetti, Amalia; Micaela, Foco; Annapaola, Ingrosso; Bonci, Enea; Laura, Conti; Marco, Matrunola. - In: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. - ISSN 1077-4114. - STAMPA. - 30:2(2008), pp. 148-152. [10.1097/mph.0b013e31815f88b7]

Venous thrombosis in children with solid tumors

SCHIAVETTI, Amalia;BONCI, Enea;
2008

Abstract

Background: The prevalence of venous thrombosis (VT) in children with solid tumor and the role of different risk factors are not defined yet. Aim: A cross-sectional observational study was conducted to evaluate the prevalence of both symptomatic and asymptomatic catheter-associated thrombosis events in children affected with different solid tumors. Methods: Patients with a solid tumor, admitted as day-care, were consecutively enrolled over a period of 10 months. All of them had a central venous line. Physical examination, D-dimer serum tests, and eco-color-Doppler ultrasonography were performed once at any time before catheter removal. Results: Forty-two patients (14 females and 28 males)-mean age 115 months-were evaluated. Five of the 42 patients (12%) had VT. In 4 of these, VT was catheter-related: 3 asymptomatic and I symptomatic. In the last patient, VT was clinically symptomatic and not catheter related. Patients with longer duration of catheter insertion presented with a higher rate of VT (P = 0.05). Moreover, patients affected with neuroblastoma showed a higher rate of VT than the others with different solid tumors (P < 0.05). Conclusions: VT was visualized by echo-color-Doppler ultrasonography in 12% of the patients; it was asymptomatic in 7%. In our small series, VT was related to neuroblastoma disease and a longer duration of catheter insertion. Prospective and multicentric studies are required to select risk factors for VT in children with solid tumors.
2008
children; solid tumor; thrombosis
01 Pubblicazione su rivista::01a Articolo in rivista
Venous thrombosis in children with solid tumors / Schiavetti, Amalia; Micaela, Foco; Annapaola, Ingrosso; Bonci, Enea; Laura, Conti; Marco, Matrunola. - In: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. - ISSN 1077-4114. - STAMPA. - 30:2(2008), pp. 148-152. [10.1097/mph.0b013e31815f88b7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/229832
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