Cardiovascular events (CE) occur most frequently in the morning hours in hypertensive subjects. We studied the association between the morning blood pressure (BP) surge and CE in prognosis of 10 normotensive and 32 well-controlled hypertensive elderly, in whom ambulatory BP monitoring was performed and who were followed prospectively for 5 years. The morning surge (MS) of BP was calculated as mean systolic BP during 2 h after awakening - mean systolic BP during 1 h that included the lowest sleep BP. During an average of 60 months, five CE occurred. When the patients were divided into two groups according to MS, those in the top terzile (MS group; MS ≥ 34 mmHg, n = 14) had a higher prevalence of CE (5 versus 0, p = 0.001) during the follow-up period, than the others (non-MS group; MS < 34 mmHg, n = 28). The logistic regression analysis showed the MS sleep-trough surge as predictive variable of CE (odds ratio, OR = 0.794, p = 0.022). In conclusion, in older normotensives and well-controlled hypertensives, a higher BP MS is associated with vascular risk independently of clinical and ambulatory BP. Reduction of the MS could thus be a therapeutic target for preventing vascular events also in non-hypertensive patients. © 2008 Elsevier Ireland Ltd. All rights reserved.

Exaggerated morning blood pressure surge and cardiovascular events. A 5-year longitudinal study in normotensive and well-controlled hypertensive elderly / Amici, Alessandro; Cicconetti, Paolo; C., Sagrafoli; A., Baratta; P., Passador; M. T., Pecci; G., Tassan; Verrusio, Walter; Marigliano, Vincenzo; Cacciafesta, Mauro. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 49:2(2009), pp. e105-e109. [10.1016/j.archger.2008.10.003]

Exaggerated morning blood pressure surge and cardiovascular events. A 5-year longitudinal study in normotensive and well-controlled hypertensive elderly

AMICI, Alessandro;CICCONETTI, Paolo;VERRUSIO, WALTER;MARIGLIANO, Vincenzo;CACCIAFESTA, Mauro
2009

Abstract

Cardiovascular events (CE) occur most frequently in the morning hours in hypertensive subjects. We studied the association between the morning blood pressure (BP) surge and CE in prognosis of 10 normotensive and 32 well-controlled hypertensive elderly, in whom ambulatory BP monitoring was performed and who were followed prospectively for 5 years. The morning surge (MS) of BP was calculated as mean systolic BP during 2 h after awakening - mean systolic BP during 1 h that included the lowest sleep BP. During an average of 60 months, five CE occurred. When the patients were divided into two groups according to MS, those in the top terzile (MS group; MS ≥ 34 mmHg, n = 14) had a higher prevalence of CE (5 versus 0, p = 0.001) during the follow-up period, than the others (non-MS group; MS < 34 mmHg, n = 28). The logistic regression analysis showed the MS sleep-trough surge as predictive variable of CE (odds ratio, OR = 0.794, p = 0.022). In conclusion, in older normotensives and well-controlled hypertensives, a higher BP MS is associated with vascular risk independently of clinical and ambulatory BP. Reduction of the MS could thus be a therapeutic target for preventing vascular events also in non-hypertensive patients. © 2008 Elsevier Ireland Ltd. All rights reserved.
2009
ambulatory blood pressure monitoring; cardiovascular disease; cardiovascular events; morning surge of blood pressure; office blood pressure
01 Pubblicazione su rivista::01a Articolo in rivista
Exaggerated morning blood pressure surge and cardiovascular events. A 5-year longitudinal study in normotensive and well-controlled hypertensive elderly / Amici, Alessandro; Cicconetti, Paolo; C., Sagrafoli; A., Baratta; P., Passador; M. T., Pecci; G., Tassan; Verrusio, Walter; Marigliano, Vincenzo; Cacciafesta, Mauro. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 49:2(2009), pp. e105-e109. [10.1016/j.archger.2008.10.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/229077
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