Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), mono-ortho and non-ortho polychlorinated biphenyls (dioxin-like PCBs) were determined in samples of human fat tissue from nine Italian obese patients. The toxicity equivalent (TEQ) values ranged from 9 to 25 pg TEQ g(-1) lipid (WHO-TEF values, 2005 [Van den Berg, M., Birnbaum, L.S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., Rose, M., Safe, S., Schrenk, D., Tohyama, C., Tritscher, A., Tuomisto, J., Tysklind, M., Walker, N., Peterson, R.E., 2006. The 2005 World Health Organization reevaluation of human and mammalian Toxic Equivalency Factors for dioxins and dioxin-like compounds. Toxicol. Sci. 93, 223-241]), the contribution of dioxin-like PCBs was more than 30% of the total TEQ values. The obese body burdens varied from 6 to 11 ng TEQ kg(-1) body weight (BW), exceeding the estimated steady-state body burden 5 ng TEQ kg(-1) BW, based on lipid adjusted serum concentrations from several populations in the mid-1990s, calculated in the risk assessment US EPA document.

TEQ(S) and body burden for PCDDs, PCDFs, and dioxin-like PCBs in human adipose tissue / LA ROCCA, C; Alivernini, S; Badiali, Marco; Cornoldi, A; Iacovella, N; Silvestroni, Leopoldo; Spera, Giovanni; TURRIO BALDASSARRI, L.. - In: CHEMOSPHERE. - ISSN 0045-6535. - STAMPA. - 73:1(2008), pp. 92-96. [10.1016/j.chemosphere.2008.04.088]

TEQ(S) and body burden for PCDDs, PCDFs, and dioxin-like PCBs in human adipose tissue

BADIALI, Marco;SILVESTRONI, Leopoldo;SPERA, Giovanni;
2008

Abstract

Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), mono-ortho and non-ortho polychlorinated biphenyls (dioxin-like PCBs) were determined in samples of human fat tissue from nine Italian obese patients. The toxicity equivalent (TEQ) values ranged from 9 to 25 pg TEQ g(-1) lipid (WHO-TEF values, 2005 [Van den Berg, M., Birnbaum, L.S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., Rose, M., Safe, S., Schrenk, D., Tohyama, C., Tritscher, A., Tuomisto, J., Tysklind, M., Walker, N., Peterson, R.E., 2006. The 2005 World Health Organization reevaluation of human and mammalian Toxic Equivalency Factors for dioxins and dioxin-like compounds. Toxicol. Sci. 93, 223-241]), the contribution of dioxin-like PCBs was more than 30% of the total TEQ values. The obese body burdens varied from 6 to 11 ng TEQ kg(-1) body weight (BW), exceeding the estimated steady-state body burden 5 ng TEQ kg(-1) BW, based on lipid adjusted serum concentrations from several populations in the mid-1990s, calculated in the risk assessment US EPA document.
2008
Adipose Tissue/chemistry; Benzofurans/analysis; Benzofurans/toxicity; Body Burden; Body Weight; Environmental Exposure; Environmental Pollutants/analysis; Environmental Pollutants/toxicity; Female; Humans; Male; Obesity/etiology; Polychlorinated Biphenyls/analysis; Polychlorinated Biphenyls/toxicity; Soil Pollutants/analysis; Soil Pollutants/toxicity; Tetrachlorodibenzodioxin/analogs & derivatives; Tetrachlorodibenzodioxin/analysis; Tetrachlorodibenzodioxin/toxicity
01 Pubblicazione su rivista::01a Articolo in rivista
TEQ(S) and body burden for PCDDs, PCDFs, and dioxin-like PCBs in human adipose tissue / LA ROCCA, C; Alivernini, S; Badiali, Marco; Cornoldi, A; Iacovella, N; Silvestroni, Leopoldo; Spera, Giovanni; TURRIO BALDASSARRI, L.. - In: CHEMOSPHERE. - ISSN 0045-6535. - STAMPA. - 73:1(2008), pp. 92-96. [10.1016/j.chemosphere.2008.04.088]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/228965
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