AIM: To evaluate the prevalence of lactose intolerance (LI) following a load of 12.5 g in patients diagnosed as high-grade malabsorbers using the hydrogen breath test (HBT)-25. METHODS: Ninety patients showing high-grade malabsorption at HBT-25 were submitted to a second HBT with a lactose load of 12.5 g. Peak hydrogen production, area under the curve of hydrogen excretion and occurrence of symptoms were recorded. RESULTS: Only 16 patients (17.77%) with positive HBT-25 proved positive at HBT-12.5. Hydrogen production was lower as compared to HBT-25 (peak value 21.55 parts per million (ppm) +/- 29.54 SD vs 99.43 ppm +/- 40.01 SD; P < 0.001). Symptoms were present in only 13 patients. The absence of symptoms during the high-dose test has a high negative predictive value (0.84) for a negative low-dose test. The presence of symptoms during the first test was not useful for predicting a positive low-dose test (positive predictive value 0.06-0.31). CONCLUSION: Most patients with a positive HBT-25 normally absorb a lower dose of lactose and a strict lactose restriction on the basis of a "standard" HBT is, in most instances, unnecessary. Thus, the 25 g lactose tolerance test should probably be substituted by the 12.5 g test in the diagnosis of LI, and in providing dietary guidelines to patients with suspected lactose malabsorption/intolerance. (C) 2008 The WJG Press. All rights reserved.

Hydrogen breath test for the diagnosis of lactose intolerance, is the routine sugar load the best one? / Fiorenza, Argnani; M., Di Camillo; V., Marinaro; Foglietta, Tiziana; Avallone, ELEONORA VERONICA; Cannella, Carlo; Vernia, Piero. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - 14:40(2008), pp. 6204-6207. [10.3748/wjg.14.6204]

Hydrogen breath test for the diagnosis of lactose intolerance, is the routine sugar load the best one?

FOGLIETTA, TIZIANA;AVALLONE, ELEONORA VERONICA;CANNELLA, Carlo;VERNIA, Piero
2008

Abstract

AIM: To evaluate the prevalence of lactose intolerance (LI) following a load of 12.5 g in patients diagnosed as high-grade malabsorbers using the hydrogen breath test (HBT)-25. METHODS: Ninety patients showing high-grade malabsorption at HBT-25 were submitted to a second HBT with a lactose load of 12.5 g. Peak hydrogen production, area under the curve of hydrogen excretion and occurrence of symptoms were recorded. RESULTS: Only 16 patients (17.77%) with positive HBT-25 proved positive at HBT-12.5. Hydrogen production was lower as compared to HBT-25 (peak value 21.55 parts per million (ppm) +/- 29.54 SD vs 99.43 ppm +/- 40.01 SD; P < 0.001). Symptoms were present in only 13 patients. The absence of symptoms during the high-dose test has a high negative predictive value (0.84) for a negative low-dose test. The presence of symptoms during the first test was not useful for predicting a positive low-dose test (positive predictive value 0.06-0.31). CONCLUSION: Most patients with a positive HBT-25 normally absorb a lower dose of lactose and a strict lactose restriction on the basis of a "standard" HBT is, in most instances, unnecessary. Thus, the 25 g lactose tolerance test should probably be substituted by the 12.5 g test in the diagnosis of LI, and in providing dietary guidelines to patients with suspected lactose malabsorption/intolerance. (C) 2008 The WJG Press. All rights reserved.
2008
hydrogen breath test; lactase deficiency; lactose intolerance; lactose malabsorption
01 Pubblicazione su rivista::01a Articolo in rivista
Hydrogen breath test for the diagnosis of lactose intolerance, is the routine sugar load the best one? / Fiorenza, Argnani; M., Di Camillo; V., Marinaro; Foglietta, Tiziana; Avallone, ELEONORA VERONICA; Cannella, Carlo; Vernia, Piero. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - 14:40(2008), pp. 6204-6207. [10.3748/wjg.14.6204]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/228829
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