Endothelial progenitor cells (EPC) can repair the endothelial layer and are considered a component of the cardiovascular system. EPC number and function may change under pathological conditions, including cardiovascular risk factors. The study was carried out to investigate circulating EPC number, in vitro function and relationship with LDL-C, HDL-C and endothelium-dependent vasodilatation in hypercholesterolemic subjects. Forty-one male and 39 female subjects, age>35 and<45, LDL cholesterol plasma level>130 mg/dl with normal (>= 50 mg/dl females and >= 40 mg/dl males) or low HDL-C, absence of any concomitant disorders and/or drug treatment, at their first diagnosis of hypercholesterolemia, were consecutively recruited in the Outpatient Service of the Medical Pathophysiology Department of Rome Sapienza University. In high LDL-C patients, circulating EPC number was decreased and EPC capability to migrate was impaired as well. This pattern was far less evident in the normal HDL-C subgroup. The endothelium-dependent vasodilatation (EDV) was significantly decreased according to the HDL-C decrease in male but not in female subjects. Univariate analysis showed a direct correlation between EPC number and EDV, and the association persisted after adjustment for sex, age and HDL-C, which were all significantly correlated to EDV, which may suggest a protective role of EPC on endothelium in vivo. Our study documented that, in hypercholesterolemic subjects, HDL-C is a strong determinant of EPC number and function, and EPC number decrease is an independent risk factor for endothelial dysfunction. (C) 2010 Elsevier Inc. All rights reserved.

HDL cholesterol is a strong determinant of endothelial progenitor cells in hypercholesterolemic subjects / Fabio, Rossi; Cora, Bertone; Federica, Montanile; Federica, Miglietta; Lubrano, Carla; Gandini, Loredana; Santiemma, Vittorio. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - 80:2(2010), pp. 274-279. [10.1016/j.mvr.2010.05.003]

HDL cholesterol is a strong determinant of endothelial progenitor cells in hypercholesterolemic subjects

LUBRANO, Carla;GANDINI, Loredana;SANTIEMMA, Vittorio
2010

Abstract

Endothelial progenitor cells (EPC) can repair the endothelial layer and are considered a component of the cardiovascular system. EPC number and function may change under pathological conditions, including cardiovascular risk factors. The study was carried out to investigate circulating EPC number, in vitro function and relationship with LDL-C, HDL-C and endothelium-dependent vasodilatation in hypercholesterolemic subjects. Forty-one male and 39 female subjects, age>35 and<45, LDL cholesterol plasma level>130 mg/dl with normal (>= 50 mg/dl females and >= 40 mg/dl males) or low HDL-C, absence of any concomitant disorders and/or drug treatment, at their first diagnosis of hypercholesterolemia, were consecutively recruited in the Outpatient Service of the Medical Pathophysiology Department of Rome Sapienza University. In high LDL-C patients, circulating EPC number was decreased and EPC capability to migrate was impaired as well. This pattern was far less evident in the normal HDL-C subgroup. The endothelium-dependent vasodilatation (EDV) was significantly decreased according to the HDL-C decrease in male but not in female subjects. Univariate analysis showed a direct correlation between EPC number and EDV, and the association persisted after adjustment for sex, age and HDL-C, which were all significantly correlated to EDV, which may suggest a protective role of EPC on endothelium in vivo. Our study documented that, in hypercholesterolemic subjects, HDL-C is a strong determinant of EPC number and function, and EPC number decrease is an independent risk factor for endothelial dysfunction. (C) 2010 Elsevier Inc. All rights reserved.
2010
epc; endothelium-dependent vasodilatation; hdl-c; cardiovascular risk factor; endothelial function; hypercholesterolemia; gender; plethysmography; ldl-c
01 Pubblicazione su rivista::01a Articolo in rivista
HDL cholesterol is a strong determinant of endothelial progenitor cells in hypercholesterolemic subjects / Fabio, Rossi; Cora, Bertone; Federica, Montanile; Federica, Miglietta; Lubrano, Carla; Gandini, Loredana; Santiemma, Vittorio. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - 80:2(2010), pp. 274-279. [10.1016/j.mvr.2010.05.003]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/228319
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 32
social impact