Lung transplantation represents the only therapeutic option for patients affected by end-stage cystic fibrosis (CF). We performed 76 lung transplantations in 73 patients from 1996-2007. The mean time on the waiting list was 10 +/- 6 months. The median follow-up after the transplantation was 69.3 months. Twenty-one transplants (27.6%) were performed under cardiopulmonary bypass. Perioperative mortality, excluding retransplants, was 16.4% (12 patients) and the causes of death were sepsis, primary graft failure, and myocardial infarction. The overall survival was 74.5% +/- 5%, 62.9% +/- 5%, 54.1% +/- 6%, and 43.4% +/- 6% at 1, 3, 5, and 10 years, respectively. The accurate selection of potential recipients and the correct timing of referral and transplantation are factors that play crucial roles to obtain satisfactory results in term of improvement of quality of life and long-term survival.
Lung transplantation for cystic fibrosis: Ten years of experience / M. T., Aratari; Venuta, Federico; DE GIACOMO, Tiziano; Rendina, Erino Angelo; Anile, Marco; Diso, Daniele; Francioni, Federico; Quattrucci, Serena; M., Rolla; Pugliese, Francesco; Liparulo, Valeria; M., Di Stasio; C., Ricella; S., Tsagkaropoulos; G., Ferretti; Coloni, Giorgio Furio. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 40:6(2008), pp. 2001-2002. (Intervento presentato al convegno 31st Congress of the Italian-Transplantation-Society tenutosi a Modena, ITALY nel NOV 28-30, 2007) [10.1016/j.transproceed.2008.05.029].
Lung transplantation for cystic fibrosis: Ten years of experience
VENUTA, Federico;DE GIACOMO, Tiziano;RENDINA, Erino Angelo;ANILE, MARCO;DISO, DANIELE;FRANCIONI, Federico;QUATTRUCCI, Serena;PUGLIESE, Francesco;LIPARULO, Valeria;COLONI, Giorgio Furio
2008
Abstract
Lung transplantation represents the only therapeutic option for patients affected by end-stage cystic fibrosis (CF). We performed 76 lung transplantations in 73 patients from 1996-2007. The mean time on the waiting list was 10 +/- 6 months. The median follow-up after the transplantation was 69.3 months. Twenty-one transplants (27.6%) were performed under cardiopulmonary bypass. Perioperative mortality, excluding retransplants, was 16.4% (12 patients) and the causes of death were sepsis, primary graft failure, and myocardial infarction. The overall survival was 74.5% +/- 5%, 62.9% +/- 5%, 54.1% +/- 6%, and 43.4% +/- 6% at 1, 3, 5, and 10 years, respectively. The accurate selection of potential recipients and the correct timing of referral and transplantation are factors that play crucial roles to obtain satisfactory results in term of improvement of quality of life and long-term survival.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
