A 69-year-old man presented with Cotard's delusions, insomnia, profound depression, amnesia, difficulty concentrating, and cognitive deficit after two different surgical interventions. Brain imaging showed frontotemporal-subcortical atrophy and lateral ventricular enlargement. He responded poorly to a combination of sertraline, amisulpride and mirtazapine, with modest benefit on insomnia, and developed hypotension. After 18 days he was switched to olanzapine and venlafaxine, but his cognition worsened. He underwent bilateral electroconvulsive therapy (ECT). His mood improved, cognitive performance increased and anxiety symptoms remitted. This improvement persisted through the one-month post-discharge follow-up and depression eventually remitted.

Improvement of cognition in a patient with Cotard's delusions and frontotemporal atrophy receiving electroconvulsive therapy (ECT) for depression / Giuseppe, Fazzari; Oliviero, Benzoni; Alessio, Sangaletti; Francesca, Bonera; Stefano, Nassini; Mazzarini, Lorenzo; Pacchiarotti, Isabella; Sani, Gabriele; Alexia Emilia, Koukopoulos; Roberto, Gasparotti; DE ROSSI, Pietro; Simone, Lazanio; Savoja, Valeria; Girardi, Paolo; Sanna, Livia. - In: INTERNATIONAL PSYCHOGERIATRICS. - ISSN 1041-6102. - STAMPA. - 21:3(2009), pp. 600-603. [10.1017/s1041610209008990]

Improvement of cognition in a patient with Cotard's delusions and frontotemporal atrophy receiving electroconvulsive therapy (ECT) for depression

MAZZARINI, LORENZO;PACCHIAROTTI, ISABELLA;SANI, Gabriele;DE ROSSI, Pietro;SAVOJA, Valeria;GIRARDI, Paolo;Sanna, Livia
2009

Abstract

A 69-year-old man presented with Cotard's delusions, insomnia, profound depression, amnesia, difficulty concentrating, and cognitive deficit after two different surgical interventions. Brain imaging showed frontotemporal-subcortical atrophy and lateral ventricular enlargement. He responded poorly to a combination of sertraline, amisulpride and mirtazapine, with modest benefit on insomnia, and developed hypotension. After 18 days he was switched to olanzapine and venlafaxine, but his cognition worsened. He underwent bilateral electroconvulsive therapy (ECT). His mood improved, cognitive performance increased and anxiety symptoms remitted. This improvement persisted through the one-month post-discharge follow-up and depression eventually remitted.
2009
cotard's syndrome; delusions; electroconvulsive therapy; frontotemporal dementia; subcortical atrophy
01 Pubblicazione su rivista::01a Articolo in rivista
Improvement of cognition in a patient with Cotard's delusions and frontotemporal atrophy receiving electroconvulsive therapy (ECT) for depression / Giuseppe, Fazzari; Oliviero, Benzoni; Alessio, Sangaletti; Francesca, Bonera; Stefano, Nassini; Mazzarini, Lorenzo; Pacchiarotti, Isabella; Sani, Gabriele; Alexia Emilia, Koukopoulos; Roberto, Gasparotti; DE ROSSI, Pietro; Simone, Lazanio; Savoja, Valeria; Girardi, Paolo; Sanna, Livia. - In: INTERNATIONAL PSYCHOGERIATRICS. - ISSN 1041-6102. - STAMPA. - 21:3(2009), pp. 600-603. [10.1017/s1041610209008990]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/227449
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