Iron homeostasis in pregnancy compensates for increased iron requirements and in women of child-bearing age for iron loss in menses. Oral administration of ferrous sulfate, prescribed to cure iron deficiency (ID) and ID anemia (IDA), often fails to increase hematological parameters and causes adverse effects. Recently, we demonstrated safety and efficacy of bovine lactoferrin (bLf) in pregnant women suffering from ID/IDA. Two clinical trials were conducted on pregnant and non-pregnant women of child-bearing age suffering from ID/IDA. In both trials, women received oral administration of bLf 100 mg/twice/day (Arm A), or ferrous sulfate 520 mg/day (Arm B). Hematological parameters, serum IL-6 and prohepcidin were assayed before and after therapy. Unlike ferrous sulfate, bLf increased hematological parameters (P<0.0001). In pregnant women, bLf decreased serum IL-6 (P<0.0001), and increased prohepcidin (P=0.0007). In non-pregnant women bLf did not change the low IL-6 levels while it increased prohepcidin (P<0.0001). Ferrous sulfate increased IL-6 (P<0.0001) and decreased prohepcidin (P=0.093). bLf established iron homeostasis by modulating serum IL-6 and prohepcidin synthesis, whereas ferrous sulfate increased IL-6 and failed to increase hematological parameters and prohepcidin. bLf is a more effective and safer alternative than ferrous sulfate for treating ID and IDA.

LACTOFERRIN EFFICACY VERSUS FERROUS SULFATE IN CURING IRON DISORDERS IN PREGNANT AND NON-PREGNANT WOMEN / Paesano, Rosalba; Berlutti, Francesca; M., Pietropaoli; W., Goolsbee; E., Pacifici; Valenti, Piera. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 23:2(2010), pp. 577-587.

LACTOFERRIN EFFICACY VERSUS FERROUS SULFATE IN CURING IRON DISORDERS IN PREGNANT AND NON-PREGNANT WOMEN

PAESANO, Rosalba;BERLUTTI, Francesca;VALENTI, PIERA
2010

Abstract

Iron homeostasis in pregnancy compensates for increased iron requirements and in women of child-bearing age for iron loss in menses. Oral administration of ferrous sulfate, prescribed to cure iron deficiency (ID) and ID anemia (IDA), often fails to increase hematological parameters and causes adverse effects. Recently, we demonstrated safety and efficacy of bovine lactoferrin (bLf) in pregnant women suffering from ID/IDA. Two clinical trials were conducted on pregnant and non-pregnant women of child-bearing age suffering from ID/IDA. In both trials, women received oral administration of bLf 100 mg/twice/day (Arm A), or ferrous sulfate 520 mg/day (Arm B). Hematological parameters, serum IL-6 and prohepcidin were assayed before and after therapy. Unlike ferrous sulfate, bLf increased hematological parameters (P<0.0001). In pregnant women, bLf decreased serum IL-6 (P<0.0001), and increased prohepcidin (P=0.0007). In non-pregnant women bLf did not change the low IL-6 levels while it increased prohepcidin (P<0.0001). Ferrous sulfate increased IL-6 (P<0.0001) and decreased prohepcidin (P=0.093). bLf established iron homeostasis by modulating serum IL-6 and prohepcidin synthesis, whereas ferrous sulfate increased IL-6 and failed to increase hematological parameters and prohepcidin. bLf is a more effective and safer alternative than ferrous sulfate for treating ID and IDA.
2010
pregnant women; lactoferrin; non-pregnant women; iron deficiency anaemia; iron deficiency
01 Pubblicazione su rivista::01a Articolo in rivista
LACTOFERRIN EFFICACY VERSUS FERROUS SULFATE IN CURING IRON DISORDERS IN PREGNANT AND NON-PREGNANT WOMEN / Paesano, Rosalba; Berlutti, Francesca; M., Pietropaoli; W., Goolsbee; E., Pacifici; Valenti, Piera. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 23:2(2010), pp. 577-587.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/227247
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 50
  • ???jsp.display-item.citation.isi??? 44
social impact