Four different methods were used to measure the "in vitro" antioxidant capacity of three cobalt complexes recently proposed as anticancer active principles: a new biosensor method and a new pulse voltammetric, or pulse polarographic method, together with two other methods - one fluorimetric and the other spectrophotometric. Results obtained using the different methods are discussed and compared with the anti-metastatic effect recently measured "in vivo" by Russian authors. The good correlation found between anti-tumoral and anti-metastatic activity ranking and in vitro antioxidant activity found by the new voltammetric method suggests interesting hypotheses based on the anti-tumoral effect of these complexes. © 2008 Bentham Science Publishers Ltd.

In vitro antioxidant capacity vs in vivo antimetastatic effect of anticancer cobalt complexes / Campanella, Luigi; Favero, Gabriele; Sergey, Osinsky; Andrej, Sigan; Tomassetti, Mauro. - In: CURRENT PHARMACEUTICAL ANALYSIS. - ISSN 1573-4129. - STAMPA. - 4:2(2008), pp. 44-52. [10.2174/157341208784246279]

In vitro antioxidant capacity vs in vivo antimetastatic effect of anticancer cobalt complexes

CAMPANELLA, Luigi;FAVERO, Gabriele;TOMASSETTI, Mauro
2008

Abstract

Four different methods were used to measure the "in vitro" antioxidant capacity of three cobalt complexes recently proposed as anticancer active principles: a new biosensor method and a new pulse voltammetric, or pulse polarographic method, together with two other methods - one fluorimetric and the other spectrophotometric. Results obtained using the different methods are discussed and compared with the anti-metastatic effect recently measured "in vivo" by Russian authors. The good correlation found between anti-tumoral and anti-metastatic activity ranking and in vitro antioxidant activity found by the new voltammetric method suggests interesting hypotheses based on the anti-tumoral effect of these complexes. © 2008 Bentham Science Publishers Ltd.
2008
antioxidant; differential pulse voltammetry; orac spectrofluorimetric method; ph value; superoxide dismutase
01 Pubblicazione su rivista::01a Articolo in rivista
In vitro antioxidant capacity vs in vivo antimetastatic effect of anticancer cobalt complexes / Campanella, Luigi; Favero, Gabriele; Sergey, Osinsky; Andrej, Sigan; Tomassetti, Mauro. - In: CURRENT PHARMACEUTICAL ANALYSIS. - ISSN 1573-4129. - STAMPA. - 4:2(2008), pp. 44-52. [10.2174/157341208784246279]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/225883
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