There is little information on the long-term effect of liver transplantation (LT) on cardiac autonomic dysfunction in cirrhotic patients. We compared cardiac autonomic function before and in the long-term after LT. in a transversal study, we investigated 30 cirrhotics awaiting LT, 15 clinically stable patients 2-6 years after LT and 27 healthy controls. Seven cirrhotic patients were studied before LT, and 6, 12 and 33 months after LT, in a prospective fashion. Cardiac autonomic function was measured by heart rate variability (HRV) analysis during 24-h electrocardiogram recording. In the transversal Study, patients with cirrhosis as compared to healthy controls had Significantly reduced standard deviation of normal-to-normal RR intervals (SDNN) (p < 0.001) and of the square root of the mean of squared differences between adjacent NN intervals (RMS-SD) (p < 0.01), while the ratio between low frequency (LF) and high frequency (HF) at night was significantly (p < 0.05) increased. Liver transplanted patients had significantly (p < 0.001) higher SDNN Values than cirrhotics, while RMS-SD and LF/HF at night did not differ. In the prospective Study, SDNN progressively increased after LT and was significantly (p < 0.05) higher at 12 and 33 months, compared to the pre-operative value. RMS-SD and LF/HF at night did not change after LT. In conclusion, the overall HRV decrease present in cirrhosis, measured by SDNN Values, is partially corrected in the long-term after LT. However, parasympathetic impairment, measured by RMS-SD and LF/HF at night, is not affected even in the long-term after operation. (C) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Long-term effect of liver transplantation on cirrhotic autonomic cardiac dysfunction / Baratta, Luigi; Tubani, Luigi; Merli, Manuela; Francesca, Labbadia; Donatella, Facchini; Rosanna De, Marco; Rossi, Massimo; Attili, Adolfo Francesco; Berloco, Pasquale Bartolomeo; GINANNI CORRADINI, Stefano. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 42:2(2010), pp. 131-136. [10.1016/j.dld.2009.05.009]

Long-term effect of liver transplantation on cirrhotic autonomic cardiac dysfunction

BARATTA, Luigi;TUBANI, Luigi;MERLI, Manuela;ROSSI, MASSIMO;ATTILI, Adolfo Francesco;BERLOCO, Pasquale Bartolomeo;GINANNI CORRADINI, Stefano
2010

Abstract

There is little information on the long-term effect of liver transplantation (LT) on cardiac autonomic dysfunction in cirrhotic patients. We compared cardiac autonomic function before and in the long-term after LT. in a transversal study, we investigated 30 cirrhotics awaiting LT, 15 clinically stable patients 2-6 years after LT and 27 healthy controls. Seven cirrhotic patients were studied before LT, and 6, 12 and 33 months after LT, in a prospective fashion. Cardiac autonomic function was measured by heart rate variability (HRV) analysis during 24-h electrocardiogram recording. In the transversal Study, patients with cirrhosis as compared to healthy controls had Significantly reduced standard deviation of normal-to-normal RR intervals (SDNN) (p < 0.001) and of the square root of the mean of squared differences between adjacent NN intervals (RMS-SD) (p < 0.01), while the ratio between low frequency (LF) and high frequency (HF) at night was significantly (p < 0.05) increased. Liver transplanted patients had significantly (p < 0.001) higher SDNN Values than cirrhotics, while RMS-SD and LF/HF at night did not differ. In the prospective Study, SDNN progressively increased after LT and was significantly (p < 0.05) higher at 12 and 33 months, compared to the pre-operative value. RMS-SD and LF/HF at night did not change after LT. In conclusion, the overall HRV decrease present in cirrhosis, measured by SDNN Values, is partially corrected in the long-term after LT. However, parasympathetic impairment, measured by RMS-SD and LF/HF at night, is not affected even in the long-term after operation. (C) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
2010
cardiac autonomic dysfunction; cirrhosis; heart rate variability; liver transplantation
01 Pubblicazione su rivista::01a Articolo in rivista
Long-term effect of liver transplantation on cirrhotic autonomic cardiac dysfunction / Baratta, Luigi; Tubani, Luigi; Merli, Manuela; Francesca, Labbadia; Donatella, Facchini; Rosanna De, Marco; Rossi, Massimo; Attili, Adolfo Francesco; Berloco, Pasquale Bartolomeo; GINANNI CORRADINI, Stefano. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 42:2(2010), pp. 131-136. [10.1016/j.dld.2009.05.009]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/225779
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