The aim of this study was to determine the effects of in vivo administration of prenatal betamethasone on leptin and adiponectin concentration in maternal and fetal circulation. Blood samples were collected from 35 pregnant women receiving betamethasone for threatened preterm delivery before and at different time points after drug administration. Cord blood was collected at delivery in infants born from mothers treated with betamethasone and in 15 infants who delivered at the same gestational age not receiving betamethasone. Betamethasone caused an approximately 170% increase in maternal leptin at 24 hours after betamethasone, whereas it had no effects on adiponectin concentration. Betamethasone affects neonatal leptin and adiponectin levels in a time-dependent manner. The glucocorticoid-induced changes in the relationship between these adipokines in maternal and fetal circulation was long lasting. These results provide the first evidence for in vivo effects of glucocorticoids on maternal and fetal adipokines relationship in human pregnancy.

Effects of prenatal betamethasone administration on leptin and adiponectin concentrations in maternal and fetal circulation / Marinoni, Emanuela; Letizia, Claudio; Ciardo, Francesca; Corona, Giovanna; Moscarini, Massimo; DI IORIO, Romolo. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - STAMPA. - 199:2(2008), pp. 141.e1-141.e6. [10.1016/j.ajog.2008.02.047]

Effects of prenatal betamethasone administration on leptin and adiponectin concentrations in maternal and fetal circulation

MARINONI, EMANUELA;LETIZIA, Claudio;CIARDO, FRANCESCA;CORONA, GIOVANNA;MOSCARINI, Massimo;DI IORIO, Romolo
2008

Abstract

The aim of this study was to determine the effects of in vivo administration of prenatal betamethasone on leptin and adiponectin concentration in maternal and fetal circulation. Blood samples were collected from 35 pregnant women receiving betamethasone for threatened preterm delivery before and at different time points after drug administration. Cord blood was collected at delivery in infants born from mothers treated with betamethasone and in 15 infants who delivered at the same gestational age not receiving betamethasone. Betamethasone caused an approximately 170% increase in maternal leptin at 24 hours after betamethasone, whereas it had no effects on adiponectin concentration. Betamethasone affects neonatal leptin and adiponectin levels in a time-dependent manner. The glucocorticoid-induced changes in the relationship between these adipokines in maternal and fetal circulation was long lasting. These results provide the first evidence for in vivo effects of glucocorticoids on maternal and fetal adipokines relationship in human pregnancy.
2008
fetus; glucocorticoids; leptin; adiponectin; pregnancy
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of prenatal betamethasone administration on leptin and adiponectin concentrations in maternal and fetal circulation / Marinoni, Emanuela; Letizia, Claudio; Ciardo, Francesca; Corona, Giovanna; Moscarini, Massimo; DI IORIO, Romolo. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - STAMPA. - 199:2(2008), pp. 141.e1-141.e6. [10.1016/j.ajog.2008.02.047]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/225539
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 11
social impact