The primary target of the biocidal action of lipodepsipeptides (LDPs) is the plasma membrane. Experiments with artificial membranes showed that the extent of membrane permeabilization was dependent on the composition of the lipid membrane and on the structure of the LDP. In lipodespinonapeptides, the presence of 4-chlorothreonine and the integrity of the lactone macrocycle were shown to be important for the pore formation.
Mechanism of action of Pseudomonas syringae lipopeptides: structure-activity relationship studies / M., DALLA SERRA; M., Coraiola; V., Fogliano; A., Fiore; A., Carpaneto; Grgurina, Ingeborg. - STAMPA. - (2005), pp. 243-243. (Intervento presentato al convegno 1ST EUROPEAN CONFERENCE ON CHEMISTRY FOR LIFE SCIENCES- Understanding the Chemical Mechanisms of Life tenutosi a RIMINI, Italy nel OCTOBER 4-8).
Mechanism of action of Pseudomonas syringae lipopeptides: structure-activity relationship studies
GRGURINA, Ingeborg
2005
Abstract
The primary target of the biocidal action of lipodepsipeptides (LDPs) is the plasma membrane. Experiments with artificial membranes showed that the extent of membrane permeabilization was dependent on the composition of the lipid membrane and on the structure of the LDP. In lipodespinonapeptides, the presence of 4-chlorothreonine and the integrity of the lactone macrocycle were shown to be important for the pore formation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
