Syringomycin (SR) structural analogues, deschloro- syringomycin (SRH) and its linear form, SRL, obtained by hydrolysis of the lactone ring, were compared in the membrane permeabilization activity. SRH was less active than the chlorinated SR in haemolytic activity assay and on liposomes.In the latter case, the influence of the presence of sterols was also observed. The lactone ring opening caused the complete loss of the membrane activity.
The interaction of syringomycin structural analogues with biological and model membranes / M., DALLA SERRA; M., Menestrina; M., Coraiola; Grgurina, Ingeborg. - STAMPA. - (2002), pp. 61-61. (Intervento presentato al convegno 6th International Conference on Pseudomonas syringae Pathovars and Related Pathogens tenutosi a Acquafredda di Maratea (PZ) Italy nel 15-19 September).
The interaction of syringomycin structural analogues with biological and model membranes
GRGURINA, Ingeborg
2002
Abstract
Syringomycin (SR) structural analogues, deschloro- syringomycin (SRH) and its linear form, SRL, obtained by hydrolysis of the lactone ring, were compared in the membrane permeabilization activity. SRH was less active than the chlorinated SR in haemolytic activity assay and on liposomes.In the latter case, the influence of the presence of sterols was also observed. The lactone ring opening caused the complete loss of the membrane activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
