The effect of cyclic nucleotide phosphodiesterase (PDE) inhibitors Zaprinast and DC-TA-46 has been tested on SK-N-MC neuroblastoma growth. Antiproliferative activity of the tested drugs was assayed both in vitro and in the xenograft model of nude mice. In clonal density experiments, the IC50 value was 3.3 M for Zaprinast and 1.9 M for DC-TA-46, while 7.5 M BCNU alkylating agent was required to obtain the same effect. SK-N-MC cells xenografted in the nude mouse showed that the administration of Zaprinast and DC-TA-46 caused a significant 50% decrease of the tumour weight. These data demonstrate that PDE inhibitors may be useful for at least reducing tumour growth; they may be of interest for further evaluation as alternative molecules in the design of multiple agent protocols for neuroblastoma treatment.

In vitro and in vivo inhibition of SK-N-MC neuroblastoma growth using cyclic nucleotide phosphodiesterase inhibitors / Giorgi, Mauro; C., Leonetti; G., Citro; Tocco, Gabriella. - In: JOURNAL OF NEURO-ONCOLOGY. - ISSN 0167-594X. - STAMPA. - 51:1(2001), pp. 25-31. [10.1023/A:1006489020190]

In vitro and in vivo inhibition of SK-N-MC neuroblastoma growth using cyclic nucleotide phosphodiesterase inhibitors

GIORGI, MAURO;TOCCO, Gabriella
2001

Abstract

The effect of cyclic nucleotide phosphodiesterase (PDE) inhibitors Zaprinast and DC-TA-46 has been tested on SK-N-MC neuroblastoma growth. Antiproliferative activity of the tested drugs was assayed both in vitro and in the xenograft model of nude mice. In clonal density experiments, the IC50 value was 3.3 M for Zaprinast and 1.9 M for DC-TA-46, while 7.5 M BCNU alkylating agent was required to obtain the same effect. SK-N-MC cells xenografted in the nude mouse showed that the administration of Zaprinast and DC-TA-46 caused a significant 50% decrease of the tumour weight. These data demonstrate that PDE inhibitors may be useful for at least reducing tumour growth; they may be of interest for further evaluation as alternative molecules in the design of multiple agent protocols for neuroblastoma treatment.
2001
Cyclic nucleotide phosphodiesterase; DC-TA-46; Growth inhibition; Human neuroblastoma; Nude mice; Zaprinast; Neurology (clinical); Cancer Research; Oncology; Neuroscience (all)
01 Pubblicazione su rivista::01a Articolo in rivista
In vitro and in vivo inhibition of SK-N-MC neuroblastoma growth using cyclic nucleotide phosphodiesterase inhibitors / Giorgi, Mauro; C., Leonetti; G., Citro; Tocco, Gabriella. - In: JOURNAL OF NEURO-ONCOLOGY. - ISSN 0167-594X. - STAMPA. - 51:1(2001), pp. 25-31. [10.1023/A:1006489020190]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/979856
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