The behaviour of sodium transport systems across the cell membrane has been poorly investigated in elderly hypertension. Sodium efflux driven by Na+/K+/Cl-cotransport activity was therefore investigated (using a novel NMR-spectroscopy method) in 5 elderly hypertensive males (mean age 78 +/- 5 years) and 5 normotensive controls (mean age 79 +/- 3 years). In order to exclude any change in cotransport activity secondary to metabolic abnormalities, both patients and controls were non-obese and had normal glucose and lipid metabolisms. The Na+/K+/Cl-cotransport evaluation was performed after three months of pharmacological wash-out, under a diet containing 120 mEq of Na+/day. The resulting data showed that Na+ efflux due to outward Na+/K+/Cl-cotransport was higher in hypertensive group than in the normotensive one (0.50 +/- 0.10 mmol Na+/l cells/hr. vs 0.33 +/- 0.03 mmol Na+/l cells/hr., respectively, p < 0.05). Intracellular Na+ content was similar in both groups. At variance with previous data from the literature, our findings indicate that the Na+/K+/Cl-cotransport activity is elevated in elderly hypertensives.

23Na NMR evaluation of human erythrocytes Na+/K+/CL-cotransport. A study in elderly hypertensives / Cacciafesta, Mauro; Ferri, C.; Scuteri, A.; Piccirillo, G.; Bellucci, C.; Persichino, L.; Ariani, A.; Marigliano, V.; Delfini, Maurizio; Miccheli, Alfredo. - In: CELLULAR AND MOLECULAR BIOLOGY. - ISSN 0145-5680. - STAMPA. - 38:8(1992), pp. 877-884.

23Na NMR evaluation of human erythrocytes Na+/K+/CL-cotransport. A study in elderly hypertensives

CACCIAFESTA, Mauro;G. Piccirillo;DELFINI, Maurizio;MICCHELI, Alfredo
1992

Abstract

The behaviour of sodium transport systems across the cell membrane has been poorly investigated in elderly hypertension. Sodium efflux driven by Na+/K+/Cl-cotransport activity was therefore investigated (using a novel NMR-spectroscopy method) in 5 elderly hypertensive males (mean age 78 +/- 5 years) and 5 normotensive controls (mean age 79 +/- 3 years). In order to exclude any change in cotransport activity secondary to metabolic abnormalities, both patients and controls were non-obese and had normal glucose and lipid metabolisms. The Na+/K+/Cl-cotransport evaluation was performed after three months of pharmacological wash-out, under a diet containing 120 mEq of Na+/day. The resulting data showed that Na+ efflux due to outward Na+/K+/Cl-cotransport was higher in hypertensive group than in the normotensive one (0.50 +/- 0.10 mmol Na+/l cells/hr. vs 0.33 +/- 0.03 mmol Na+/l cells/hr., respectively, p < 0.05). Intracellular Na+ content was similar in both groups. At variance with previous data from the literature, our findings indicate that the Na+/K+/Cl-cotransport activity is elevated in elderly hypertensives.
1992
01 Pubblicazione su rivista::01a Articolo in rivista
23Na NMR evaluation of human erythrocytes Na+/K+/CL-cotransport. A study in elderly hypertensives / Cacciafesta, Mauro; Ferri, C.; Scuteri, A.; Piccirillo, G.; Bellucci, C.; Persichino, L.; Ariani, A.; Marigliano, V.; Delfini, Maurizio; Miccheli, Alfredo. - In: CELLULAR AND MOLECULAR BIOLOGY. - ISSN 0145-5680. - STAMPA. - 38:8(1992), pp. 877-884.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/19129
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