Central nervous system (CNS) tumor patients commonly undergo multimodality treatment in the course of their disease. Adverse effects and complications from these interventions have not been systematically studied, but pose significant challenges in clinical practice and impact function and quality of life, especially in the management of long-term brain tumor survivors. Here, the European Association of Neuro-Oncology (EANO) has developed recommendations to prevent, diagnose, and manage adverse effects and complications in the adult primary brain CNS tumor (except lymphomas) patient population with a specific focus on surgery, radiotherapy, and pharmacotherapy. Specifically, we also provide recommendations for dose adaptations, interruptions, and reexposure for pharmacotherapy that may serve as a reference for the management of standard of care in clinical trials. We also summarize which interventions are unnecessary, inactive or contraindicated. This consensus paper should serve as a reference for the conduct of standard therapy within and outside of clinical trials.

Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults / Weller, M.; Le Rhun, E.; Van Den Bent, M.; Chang, S. M.; Cloughesy, T. F.; Goldbrunner, R.; Hong, Y. -K.; Jalali, R.; Jenkinson, M. D.; Minniti, G.; Nagane, M.; Razis, E.; Roth, P.; Ruda, R.; Tabatabai, G.; Wen, P. Y.; Short, S. C.; Preusser, M.. - In: NEURO-ONCOLOGY. - ISSN 1522-8517. - 25:7(2023), pp. 1200-1224. [10.1093/neuonc/noad038]

Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults

Minniti G.;
2023

Abstract

Central nervous system (CNS) tumor patients commonly undergo multimodality treatment in the course of their disease. Adverse effects and complications from these interventions have not been systematically studied, but pose significant challenges in clinical practice and impact function and quality of life, especially in the management of long-term brain tumor survivors. Here, the European Association of Neuro-Oncology (EANO) has developed recommendations to prevent, diagnose, and manage adverse effects and complications in the adult primary brain CNS tumor (except lymphomas) patient population with a specific focus on surgery, radiotherapy, and pharmacotherapy. Specifically, we also provide recommendations for dose adaptations, interruptions, and reexposure for pharmacotherapy that may serve as a reference for the management of standard of care in clinical trials. We also summarize which interventions are unnecessary, inactive or contraindicated. This consensus paper should serve as a reference for the conduct of standard therapy within and outside of clinical trials.
2023
adverse affects; dose; interruptions; prevention; reexposure; toxicity
01 Pubblicazione su rivista::01a Articolo in rivista
Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults / Weller, M.; Le Rhun, E.; Van Den Bent, M.; Chang, S. M.; Cloughesy, T. F.; Goldbrunner, R.; Hong, Y. -K.; Jalali, R.; Jenkinson, M. D.; Minniti, G.; Nagane, M.; Razis, E.; Roth, P.; Ruda, R.; Tabatabai, G.; Wen, P. Y.; Short, S. C.; Preusser, M.. - In: NEURO-ONCOLOGY. - ISSN 1522-8517. - 25:7(2023), pp. 1200-1224. [10.1093/neuonc/noad038]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1719020
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