In this paper the problem is considered of FCM histogram processing in the case of mixtures of two or more cell populations, which appears of great interest in diagnosis and treatment of tumor diseases. A suitable mathematical model is first developed in order to represent the pattern of DNA and fluorescence distribution in the samples. An optimization procedure is then proposed for the automatic estimation of the unknown model parameters, which employs a version of Newton's method.
Analysis of DNA Distributions from Flow Cytometry By Means of an Optimization Procedure / F., Lampariello; Lucidi, Stefano. - STAMPA. - 84(1986), pp. 478-487. [10.1007/bfb0043872].
Analysis of DNA Distributions from Flow Cytometry By Means of an Optimization Procedure
LUCIDI, Stefano
1986
Abstract
In this paper the problem is considered of FCM histogram processing in the case of mixtures of two or more cell populations, which appears of great interest in diagnosis and treatment of tumor diseases. A suitable mathematical model is first developed in order to represent the pattern of DNA and fluorescence distribution in the samples. An optimization procedure is then proposed for the automatic estimation of the unknown model parameters, which employs a version of Newton's method.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
