Rheumatoid arthritis (RA) is an autoimmune disorder in which gut and oral microbiota play a crucial role. Diet is a modifiable factor that can influence both microbiota composition and arthritis outcome; previous studies have suggested associations between dietary habits and RA, with contrasting results. We investigate the protective effect of the Mediterranean diet (MD) on disease activity and the gut microbiota profile in RA patients. Sixty consecutive RA patients were enrolled upon filling a validated 14-item questionnaire for the assessment of adherence to the Mediterranean diet (Prevention with Mediterranean Diet-PREDIMED). Then, 16S analysis was employed to explore the gut microbiota within the two cohorts of patients. Patients with high adherence to MD (20) had a significantly lower C-reactive protein (p < 0.037) and disease activity (p < 0.034) than the 40 patients with low/moderate adherence to MD. An inverse association between MD and disease activity was confirmed by multivariate analysis after adjustments for all the different demographic, clinical and serologic variables. A healthier gut microbiota composition was observed in the high adherence group, with a significant decrease in Lactobacillaceae and an almost complete absence of Prevotella copri with respect to the low/moderate adherence group. In conclusion, our findings support the protective role of MD on disease activity and microbiota composition in RA patients, and suggest the feasibility of shifting the habitual diet to modulate the gut microbiota and promote the benefits associated with MD.

Impact of mediterranean diet on disease activity and gut microbiota composition of rheumatoid arthritis patients / Picchianti Diamanti, A.; Panebianco, C.; Salerno, G.; Di Rosa, R.; Salemi, S.; Sorgi, M. L.; Meneguzzi, G.; Mariani, M. B.; Rai, A.; Iacono, D.; Sesti, G.; Pazienza, V.; Lagana, B.. - In: MICROORGANISMS. - ISSN 2076-2607. - 8:12(2020), pp. 1-14. [10.3390/microorganisms8121989]

Impact of mediterranean diet on disease activity and gut microbiota composition of rheumatoid arthritis patients

Picchianti Diamanti A.;Salerno G.;Di Rosa R.;Sorgi M. L.;Meneguzzi G.;Mariani M. B.;Rai A.;Iacono D.;Sesti G.
Supervision
;
Lagana B.
Writing – Review & Editing
2020

Abstract

Rheumatoid arthritis (RA) is an autoimmune disorder in which gut and oral microbiota play a crucial role. Diet is a modifiable factor that can influence both microbiota composition and arthritis outcome; previous studies have suggested associations between dietary habits and RA, with contrasting results. We investigate the protective effect of the Mediterranean diet (MD) on disease activity and the gut microbiota profile in RA patients. Sixty consecutive RA patients were enrolled upon filling a validated 14-item questionnaire for the assessment of adherence to the Mediterranean diet (Prevention with Mediterranean Diet-PREDIMED). Then, 16S analysis was employed to explore the gut microbiota within the two cohorts of patients. Patients with high adherence to MD (20) had a significantly lower C-reactive protein (p < 0.037) and disease activity (p < 0.034) than the 40 patients with low/moderate adherence to MD. An inverse association between MD and disease activity was confirmed by multivariate analysis after adjustments for all the different demographic, clinical and serologic variables. A healthier gut microbiota composition was observed in the high adherence group, with a significant decrease in Lactobacillaceae and an almost complete absence of Prevotella copri with respect to the low/moderate adherence group. In conclusion, our findings support the protective role of MD on disease activity and microbiota composition in RA patients, and suggest the feasibility of shifting the habitual diet to modulate the gut microbiota and promote the benefits associated with MD.
2020
disease activity; gut microbiota; mediterranean diet; rheumatoid arthritis
01 Pubblicazione su rivista::01a Articolo in rivista
Impact of mediterranean diet on disease activity and gut microbiota composition of rheumatoid arthritis patients / Picchianti Diamanti, A.; Panebianco, C.; Salerno, G.; Di Rosa, R.; Salemi, S.; Sorgi, M. L.; Meneguzzi, G.; Mariani, M. B.; Rai, A.; Iacono, D.; Sesti, G.; Pazienza, V.; Lagana, B.. - In: MICROORGANISMS. - ISSN 2076-2607. - 8:12(2020), pp. 1-14. [10.3390/microorganisms8121989]
File allegati a questo prodotto
File Dimensione Formato  
PicchiantiDiamanti_Impact-mediterranean-diet_2020.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 1.86 MB
Formato Adobe PDF
1.86 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1561865
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 27
social impact