Compds. for the treatment of rhinovirus infections are claimed.; such compds. are e.g. 1-(2-chloro-5-thienyl)-4-[4-(4,5-dihydro-2-oxazolyl)phenoxy]-1-butanone (I) or 4-[5-[4-(carboxyphenoxy)]-1-oxopentyl]-1-methyl-1H-pyrrole-2-carboxaldehyde (II). Condensation of 2-chloro-5-(5-chloropentanoyl)thiophene with 2-(4-hydroxyphenyl)-4,5-dihydrooxazole gave I (97% yield). I inhibited HRV-14 selectively. [on SciFinder(R)]
(chlorothienyl)[(dihydrooxazolyl)phenoxy]butanone or [(carboxyphenoxy)oxopentyl]methyl-1H-pyrrolecarboxaldehyde and analogs, methods for their preparation and their use for the inhibition of rhinovirus infections / Artico, Marino; Corelli, Federico; Massa, Silvio; Mai, Antonello.. - (1991).
(chlorothienyl)[(dihydrooxazolyl)phenoxy]butanone or [(carboxyphenoxy)oxopentyl]methyl-1H-pyrrolecarboxaldehyde and analogs, methods for their preparation and their use for the inhibition of rhinovirus infections
Artico, Marino;Mai, Antonello.
1991
Abstract
Compds. for the treatment of rhinovirus infections are claimed.; such compds. are e.g. 1-(2-chloro-5-thienyl)-4-[4-(4,5-dihydro-2-oxazolyl)phenoxy]-1-butanone (I) or 4-[5-[4-(carboxyphenoxy)]-1-oxopentyl]-1-methyl-1H-pyrrole-2-carboxaldehyde (II). Condensation of 2-chloro-5-(5-chloropentanoyl)thiophene with 2-(4-hydroxyphenyl)-4,5-dihydrooxazole gave I (97% yield). I inhibited HRV-14 selectively. [on SciFinder(R)]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
