The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF-7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.

Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19) / Scagnolari, Carolina; Pierangeli, Alessandra; Frasca, Federica; Bitossi, Camilla; Viscido, Agnese; Oliveto, Giuseppe; Scordio, Mirko; Mazzuti, Laura; Di Carlo, Daniele; Gentile, Massimo; Solimini, Angelo; Ceccarelli, Giancarlo; Pugliese, Francesco; Mastroianni, Claudio Maria; d'Ettorre, Gabriella; Turriziani, Ombretta; Antonelli, Guido. - In: VIRUS RESEARCH. - ISSN 0168-1702. - (2021). [10.1016/j.virusres.2020.198283]

Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19)

Scagnolari, Carolina;Pierangeli, Alessandra;Frasca, Federica;Bitossi, Camilla;Viscido, Agnese;Oliveto, Giuseppe;Scordio, Mirko;Mazzuti, Laura;Di Carlo, Daniele;Gentile, Massimo;Solimini, Angelo;Ceccarelli, Giancarlo;Pugliese, Francesco;Mastroianni, Claudio Maria;d'Ettorre, Gabriella;Turriziani, Ombretta;Antonelli, Guido
2021

Abstract

The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF-7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1474219
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