Study design:This is an observational prospective noncontrolled study. We enrolled 105 patients affected by neurogenic detrusor overactivity (NDO) who underwent botulinum neurotoxin A (BONT-A) intradetrusor injection and were followed-up for 270 days.Objectives:To investigate the use of oxybutynin after BONT-A administration in NDO patients.Setting:Careggi University Hospital in Florence and Tor Vergata University Hospital in Rome.Methods:Prospective data from two Italian centers were collected in 1 year. Patients showing limited efficacy but good tolerability and adherence to oxybutynin 5 mg three times a day (t.i.d.). were enrolled in the study. Patients received BONT-A intradetrusor injection (onabotulinumtoxinA, 300 U) with a trigone-sparing technique, and the use of oxybutynin was registered at every visit.Results:105 patients were included. At visit 1, only 30 patients (28.6%) used oxybutynin t.i.d., whereas 47 (45,2%) used a lower dosage and 28 (26.7%) stopped the therapy. At visit 2, 77.3% of patients who had reduced oxybutynin intake, maintained the dosage decided at visit 1. At visit 3, 51.9% returned to oxybutynin t.i.d.; 44.8% were on a reduced dosage and only 3 (2.9%) were not taking the drug. At visit 4, only 37.5% of patients were taking less than oxybutynin t.i.d.Conclusion:This study provides some important insights on the use of oral antimuscarinics in patients treated by means of BONT-A intradetrusor administration for NDO; in particular, it suggests that, after an initial reduction in the use of oxybutynin, patients tend to increase the dosage of this drug during the follow-up after the BONT-A treatment.

The use of oxybutynin in patients treated by means of botulinum neurotoxin A for neurogenic detrusor overactivity. An observational study / Finazzi-Agro, E.; Topazio, L.; Perugia, C.; Lombardi, G.; Finita Celso, M.; De Nunzio, C.; Del Popolo, G.. - In: SPINAL CORD. - ISSN 1362-4393. - 51:8(2013), pp. 637-641. [10.1038/sc.2013.42]

The use of oxybutynin in patients treated by means of botulinum neurotoxin A for neurogenic detrusor overactivity. An observational study

De Nunzio C.;
2013

Abstract

Study design:This is an observational prospective noncontrolled study. We enrolled 105 patients affected by neurogenic detrusor overactivity (NDO) who underwent botulinum neurotoxin A (BONT-A) intradetrusor injection and were followed-up for 270 days.Objectives:To investigate the use of oxybutynin after BONT-A administration in NDO patients.Setting:Careggi University Hospital in Florence and Tor Vergata University Hospital in Rome.Methods:Prospective data from two Italian centers were collected in 1 year. Patients showing limited efficacy but good tolerability and adherence to oxybutynin 5 mg three times a day (t.i.d.). were enrolled in the study. Patients received BONT-A intradetrusor injection (onabotulinumtoxinA, 300 U) with a trigone-sparing technique, and the use of oxybutynin was registered at every visit.Results:105 patients were included. At visit 1, only 30 patients (28.6%) used oxybutynin t.i.d., whereas 47 (45,2%) used a lower dosage and 28 (26.7%) stopped the therapy. At visit 2, 77.3% of patients who had reduced oxybutynin intake, maintained the dosage decided at visit 1. At visit 3, 51.9% returned to oxybutynin t.i.d.; 44.8% were on a reduced dosage and only 3 (2.9%) were not taking the drug. At visit 4, only 37.5% of patients were taking less than oxybutynin t.i.d.Conclusion:This study provides some important insights on the use of oral antimuscarinics in patients treated by means of BONT-A intradetrusor administration for NDO; in particular, it suggests that, after an initial reduction in the use of oxybutynin, patients tend to increase the dosage of this drug during the follow-up after the BONT-A treatment.
2013
antimuscarinics; botulinum toxin-A injection; neurogenic detrusor overactivity; overactive bladder; oxybutynin
01 Pubblicazione su rivista::01a Articolo in rivista
The use of oxybutynin in patients treated by means of botulinum neurotoxin A for neurogenic detrusor overactivity. An observational study / Finazzi-Agro, E.; Topazio, L.; Perugia, C.; Lombardi, G.; Finita Celso, M.; De Nunzio, C.; Del Popolo, G.. - In: SPINAL CORD. - ISSN 1362-4393. - 51:8(2013), pp. 637-641. [10.1038/sc.2013.42]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1460324
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