This was a multicentre, prospective, long-term study evaluating a group of patients suffering from GTCS with and without PPR. They were enrolled from four centres in Italy. The study has been approved by the local Ethics Committees of the four centres. All subjects had been diagnosed according to International League Against Epilepsy criteria (6). Only patients without any history of previous treatment have been enrolled. Patients with insufficient documentation of seizure frequency, poor compliance, progressive neurological diseases, severe psychiatric disorders, drug or alcohol abuse, internal diseases or laboratory abnormalities were not elegible for the study. The primary end-point of the study was the prediction of the number of the seizures or seizure freedom by absence of PPR. The quality of seizure control has been calculated as follows. The efficacy of VPA therapy was calculated by counting seizures during therapy. The response to VPA treatment was classified as: seizure free: 100% seizure control; responders: 1 seizure during therapy; seizure resistance: persistence of 2 or more seizures during therapy. The secondary end-point was the normalization of the EEG at the end of follow-up. Our experience confirms that this type of patient with epilepsy has a good prognosis for control of seizures: more than 60% of our patients showed an excellent response to VPA monotherapy.

Idiopathic generalized tonic-clonic epilepsy and photosensitivity: a long-term follow-up study / A., Verrotti; F., Fiori; G., Coppola; E., Franzoni; Parisi, Pasquale; F., Chiarelli. - In: ACTA PAEDIATRICA. - ISSN 0803-5253. - STAMPA. - 98:12(2009), pp. 1999-2001. [10.1111/j.1651-2227.2009.01486.x]

Idiopathic generalized tonic-clonic epilepsy and photosensitivity: a long-term follow-up study

PARISI, Pasquale;
2009

Abstract

This was a multicentre, prospective, long-term study evaluating a group of patients suffering from GTCS with and without PPR. They were enrolled from four centres in Italy. The study has been approved by the local Ethics Committees of the four centres. All subjects had been diagnosed according to International League Against Epilepsy criteria (6). Only patients without any history of previous treatment have been enrolled. Patients with insufficient documentation of seizure frequency, poor compliance, progressive neurological diseases, severe psychiatric disorders, drug or alcohol abuse, internal diseases or laboratory abnormalities were not elegible for the study. The primary end-point of the study was the prediction of the number of the seizures or seizure freedom by absence of PPR. The quality of seizure control has been calculated as follows. The efficacy of VPA therapy was calculated by counting seizures during therapy. The response to VPA treatment was classified as: seizure free: 100% seizure control; responders: 1 seizure during therapy; seizure resistance: persistence of 2 or more seizures during therapy. The secondary end-point was the normalization of the EEG at the end of follow-up. Our experience confirms that this type of patient with epilepsy has a good prognosis for control of seizures: more than 60% of our patients showed an excellent response to VPA monotherapy.
2009
photosensitive epilepsy; valpric acid; long-term follow-up study
01 Pubblicazione su rivista::01l Trial clinico
Idiopathic generalized tonic-clonic epilepsy and photosensitivity: a long-term follow-up study / A., Verrotti; F., Fiori; G., Coppola; E., Franzoni; Parisi, Pasquale; F., Chiarelli. - In: ACTA PAEDIATRICA. - ISSN 0803-5253. - STAMPA. - 98:12(2009), pp. 1999-2001. [10.1111/j.1651-2227.2009.01486.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/145879
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