Hydrogen exchange experiments provide detailed information about the local stability and the solvent accessibility of different regions of the structures of folded proteins, protein complexes, and amyloid fibrils. We introduce an approach to predict protection factors from hydrogen exchange in proteins based on the knowledge of their amino acid sequences without the inclusion of any additional structural information. These results suggest that the propensity of different regions of the structures of globular proteins to undergo local unfolding events can be predicted from their amino acid sequences with an accuracy of 80% or better. © 2007 Elsevier Ltd. All rights reserved.

Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences / Tartaglia, G. G.; Cavalli, A.; Vendruscolo, M.. - In: STRUCTURE. - ISSN 0969-2126. - 15:2(2007), pp. 139-143. [10.1016/j.str.2006.12.007]

Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences

Tartaglia G. G.;Vendruscolo M.
2007

Abstract

Hydrogen exchange experiments provide detailed information about the local stability and the solvent accessibility of different regions of the structures of folded proteins, protein complexes, and amyloid fibrils. We introduce an approach to predict protection factors from hydrogen exchange in proteins based on the knowledge of their amino acid sequences without the inclusion of any additional structural information. These results suggest that the propensity of different regions of the structures of globular proteins to undergo local unfolding events can be predicted from their amino acid sequences with an accuracy of 80% or better. © 2007 Elsevier Ltd. All rights reserved.
2007
PROTEINS; Amino Acid Sequence; Animals; Computational Biology; Humans; Hydrogen; Proteins; Models, Chemical; Protein Folding
01 Pubblicazione su rivista::01a Articolo in rivista
Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences / Tartaglia, G. G.; Cavalli, A.; Vendruscolo, M.. - In: STRUCTURE. - ISSN 0969-2126. - 15:2(2007), pp. 139-143. [10.1016/j.str.2006.12.007]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1452091
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