Oleoylethanolamide (OEA) is an endogenous lipid that contributes in important ways to the peripheral regulation of food intake. When administered intraperitoneally, OEA is a potent satiety-inducing anorexiant in rats and mice [Nature 414 (2001) 209; Neuropsycopharmacology 28 (2003) 1311; Nature 425 (2003) 90]. In the present study, we show that oral administration of OEA in pH-sensitive enteric-coated capsules produces a profound and long-lasting inhibition of food intake in free-feeding rats. This effect is accompanied by a marked elevation in OEA levels in the small intestine, but not in brain or muscle.

Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration / Oveisi, F; Gaetani, Silvana; Eng, Ktp; Piomelli, D.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 49(5):(2004), pp. 461-466. [10.1016/j.phrs.2003.12.006]

Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration

GAETANI, SILVANA;
2004

Abstract

Oleoylethanolamide (OEA) is an endogenous lipid that contributes in important ways to the peripheral regulation of food intake. When administered intraperitoneally, OEA is a potent satiety-inducing anorexiant in rats and mice [Nature 414 (2001) 209; Neuropsycopharmacology 28 (2003) 1311; Nature 425 (2003) 90]. In the present study, we show that oral administration of OEA in pH-sensitive enteric-coated capsules produces a profound and long-lasting inhibition of food intake in free-feeding rats. This effect is accompanied by a marked elevation in OEA levels in the small intestine, but not in brain or muscle.
2004
meal pattern; enteric coating
01 Pubblicazione su rivista::01a Articolo in rivista
Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration / Oveisi, F; Gaetani, Silvana; Eng, Ktp; Piomelli, D.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 49(5):(2004), pp. 461-466. [10.1016/j.phrs.2003.12.006]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/144930
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 92
  • ???jsp.display-item.citation.isi??? 89
social impact