Retinal involvement and ocular findings in COVID-19 pneumonia patients

Changes in immune and coagulation systems and possible viral spread through the blood–brain barrier have been described in SARS‐CoV‐2 infection. In this study, we evaluated the possible retinal involvement and ocular findings in severe COVID‐19 pneumonia patients. A cross‐sectional study was conducted on 46 patients affected by severe COVID‐19 who were hospitalized in one intensive care unit (ICU) and in two infectious disease wards, including bedside eye screening, corneal sensitivity assessment and retinography. A total of 43 SARS‐CoV‐2‐positive pneumonia patients affected with COVID‐19 pneumonia were included, including 25 males and 18 females, with a median age of 70 years [IQR 59–78]. Except for one patient with unilateral posterior chorioretinitis of opportunistic origin, of whom aqueous tap was negative for SARS‐CoV‐2, no further retinal manifestation related to COVID‐19 infection was found in our cohort. We found 3 patients (7%) with bilateral conjunctivitis in whom PCR analysis on conjunctival swabs provided negative results for SARS‐CoV‐2. No alterations in corneal sensitivity were found. We demonstrated the absence of retinal involvement in SARS‐CoV‐2 pneumonia patients. Ophthalmologic evaluation in COVID‐19, particularly in patients hospitalized in an ICU setting, may be useful to reveal systemic co‐infections by opportunistic pathogens.