Purpose: Occlusion caused by myointimal hyperplasia appears to be the main reason of late failure of polytetrafluoroethylene (PTFE) arterial bypass grafts. Evidence exists that growth factors are involved in the genesis of myointimal hyperplasia. The aim of this study was to assess the release of platelet-derived growth factor (PDGF) and basic fibroblastic growth factor (bFGF) by PTFE arterial grafts. Methods: In 15 inbred Lewis rats a 1 cm long segment of PTFE was interposed at the level of the abdominal aorta. In a control group of another 15 Lewis rats a vein graft was implanted at the level of the abdominal aorta. Animals were killed 4 weeks after implantation and the tissue was studied in organ culture for release of PDGF AA, PDGF BB, and bFGF. Results: PTFE grafts released a greater quantity of PDGF AA than did control vein grafts (28 ± 4 ng/cm2/72 hr vs 7 ± 2 ng/cm2/72 hr). Similarly, PTFE grafts released a greater quantity of bFGF than did arterial vein grafts (308 ± 22 ng/cm2/72 hr vs 204 ± 20 ng/cm2/72 hr). Conclusions: We conclude that PTFE arterial grafts release a high quantity of growth factor, which could explain, in part, the occurrence of distal anastomotic myointimal hyperplasia.
Growth factor production after polytetrafluoroethylene and vein arterial grafting: An experimental study / Sterpetti, A. V.; Lepidi, S.; Cucina, A.; Patrizi, A. L.; Palumbo, R.; Taranta, A.; Stipa, F.; Cavallaro, A.; Santoro-D'Angelo, L.; Stipa, S.. - In: JOURNAL OF VASCULAR SURGERY. - ISSN 0741-5214. - 23:3(1996), pp. 453-460. [10.1016/S0741-5214(96)80010-3]
Growth factor production after polytetrafluoroethylene and vein arterial grafting: An experimental study
Sterpetti A. V.;Cucina A.;Palumbo R.;Taranta A.;Cavallaro A.;Santoro-D'Angelo L.;Stipa S.
1996
Abstract
Purpose: Occlusion caused by myointimal hyperplasia appears to be the main reason of late failure of polytetrafluoroethylene (PTFE) arterial bypass grafts. Evidence exists that growth factors are involved in the genesis of myointimal hyperplasia. The aim of this study was to assess the release of platelet-derived growth factor (PDGF) and basic fibroblastic growth factor (bFGF) by PTFE arterial grafts. Methods: In 15 inbred Lewis rats a 1 cm long segment of PTFE was interposed at the level of the abdominal aorta. In a control group of another 15 Lewis rats a vein graft was implanted at the level of the abdominal aorta. Animals were killed 4 weeks after implantation and the tissue was studied in organ culture for release of PDGF AA, PDGF BB, and bFGF. Results: PTFE grafts released a greater quantity of PDGF AA than did control vein grafts (28 ± 4 ng/cm2/72 hr vs 7 ± 2 ng/cm2/72 hr). Similarly, PTFE grafts released a greater quantity of bFGF than did arterial vein grafts (308 ± 22 ng/cm2/72 hr vs 204 ± 20 ng/cm2/72 hr). Conclusions: We conclude that PTFE arterial grafts release a high quantity of growth factor, which could explain, in part, the occurrence of distal anastomotic myointimal hyperplasia.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
