A set of ten C5-chiral 4,5-dihydro-(1. H)-pyrazole derivatives was synthesized and analyzed by high-performance liquid chromatography (HPLC) on the polysaccharide-based Chiralcel OJ-H chiral stationary phase (CSP). The enantioseparations were carried out using pure ethanol as eluent. Different structural elements of the investigated compounds were recognized for obtaining a very high enantioselectivity. In order to clarify some aspects of the chiral discrimination process, the thermodynamic parameters associated to the enantiorecognition and the enantiomer elution order were established. © 2011 Elsevier B.V.
A chromatographic study on the exceptional enantioselectivity of cellulose tris(4-methylbenzoate) towards C5-chiral 4,5-dihydro-(1H)-pyrazole derivatives / Roberto, Cirilli; Stefano, Alcaro; Rossella, Fioravanti; Rosella, Ferretti; Bolasco, Adriana; Bruno, Gallinella; Cristina, Faggi. - In: JOURNAL OF CHROMATOGRAPHY. - ISSN 0021-9673. - 1218:33(2011), pp. 5653-5657. [10.1016/j.chroma.2011.06.081]
A chromatographic study on the exceptional enantioselectivity of cellulose tris(4-methylbenzoate) towards C5-chiral 4,5-dihydro-(1H)-pyrazole derivatives
BOLASCO, Adriana;
2011
Abstract
A set of ten C5-chiral 4,5-dihydro-(1. H)-pyrazole derivatives was synthesized and analyzed by high-performance liquid chromatography (HPLC) on the polysaccharide-based Chiralcel OJ-H chiral stationary phase (CSP). The enantioseparations were carried out using pure ethanol as eluent. Different structural elements of the investigated compounds were recognized for obtaining a very high enantioselectivity. In order to clarify some aspects of the chiral discrimination process, the thermodynamic parameters associated to the enantiorecognition and the enantiomer elution order were established. © 2011 Elsevier B.V.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
