Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH on viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein.
Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus / E., Garaci; Palamara, ANNA TERESA; P., Di Francesco; C., Favalli; Ciriolo, M. R.; G., Rotilio. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 188:(1992), pp. 1090-1096. [10.1016/0006-291X(92)91343-O]
Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus
PALAMARA, ANNA TERESA;
1992
Abstract
Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH on viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
