Since the new fatal pneumonia was identified in December 2019 in Wuhan, China, the WHO declared the infection a health emergency of international concern. The novel ss-RNA ß-coronavirus (SARS-CoV-2) spreads through airborne and direct contagion; virulence is high in the elderly and in patients with diabetes, chronic pulmonary, cardiovascular and neoplastic diseases. SARS-CoV-2 ssRNA is recognized by intracellular Pattern Recognition Receptors (PRRs), which trigger NF-kB - the master regulator of inflammation - and Interferon Regulatory Factors (IRFs)1 .
"Toxic erythema" and eosinophilia associated to tocilizumab therapy in a COVID-19 patient / Sernicola, Alvise; Carnicelli, Giorgia; Di Fraia, M; Chello, Camilla; Furlan, C; Muharremi, R; Paolino, Giovanni; Grieco, Teresa. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - 12:(2020), pp. 1-3. [10.1111/jdv.16620]
"Toxic erythema" and eosinophilia associated to tocilizumab therapy in a COVID-19 patient
Sernicola, AlvisePrimo
;Carnicelli, GiorgiaSecondo
;Di Fraia, M;Chello, Camilla;Furlan, C;Muharremi, R;Paolino, GiovanniPenultimo
;Grieco, Teresa
Ultimo
2020
Abstract
Since the new fatal pneumonia was identified in December 2019 in Wuhan, China, the WHO declared the infection a health emergency of international concern. The novel ss-RNA ß-coronavirus (SARS-CoV-2) spreads through airborne and direct contagion; virulence is high in the elderly and in patients with diabetes, chronic pulmonary, cardiovascular and neoplastic diseases. SARS-CoV-2 ssRNA is recognized by intracellular Pattern Recognition Receptors (PRRs), which trigger NF-kB - the master regulator of inflammation - and Interferon Regulatory Factors (IRFs)1 .| File | Dimensione | Formato | |
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Sernicola_Toxic-erythema_2020_pp.pdf
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Note: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272956/
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Note: https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdv.16620
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