Autologous plasma in aesthetic & regenerative medicine and the role of PRP and PPP. Regeneration, fibrosis or only matrix? A retrospective study

Background: PRP is used in aesthetic medicine due to the high concentration of platelets and their content of growth factors. A comparative study of results has never been conducted between the single PRP fraction and the rest of the plasma available in the test tube. Objective: Review the standard protocols, avoiding the elimination of the smaller portions of PRP that are poor of platelets, due to the high probability that they possesses traits that assist with responses in the modulation and transduction of signals that are induced by growth factors. Methods: This study was carried-out on 424 patients who underwent biostimulation treatments via autologous plasma. The patients were randomly divided into two equal groups of 212. The first group was treated with biostimulation through PRP, while the other group was subjected to biostimulation with autologous Plasma, without the exclusion of the plasma poor of platelets (PPP). Results: This retrospective evaluation has allowed us to consider that the treatment method performed with all the autologous plasma it is more effective than the exclusive use of the platelet-rich plasma portion. Conclusions: We observed a greater therapeutic response with the entire autologous plasma. We obtained a greater response from the younger patients in both groups, due to the greater presence of stimulated adult stem cells.