Background: Quetiapine, an atypical antipsychotic endowed with weak dopamine antagonist, potent 5-HT2A-blocking, partial 5-HT1A-agonist, anti-H1 histamine, adrenolytic, and sigma1 receptor agonist activities, since an original 2004 report is increasingly misused. Although some of its pharmacodynamics might explain some motives for voluptuary use, most of its actions are directed at setting-off those motives. Hence, it is possible that its popularity in special populations is due to the fact that the unpleasant or unwanted effects of addiction substances are somehow soothed by quetiapine. Currently, quetiapine is tested in substance use disorders, showing some promise, but it is likely to be misused in certain contexts. Objectives: To review the evidence for the use of quetiapine as addiction substance and investigate the characteristics of populations involved in such addiction. Methods: A systematic review of literature on various databases retrieved on September 7, 2018 87 records to comment. Results. We reviewed the evidence for quetiapine’s addictive potential in the light of its pharmacodynamics properties and presented two cases of recreational quetiapine use, by a 35-year old male patient with past addictive behavior and by a 50-year-old woman with major depressive disorder and conversion disorder. We found quetiapine to be abused mainly by addict populations and people with law involvement. Conclusions/Importance: There is no reason to include quetiapine among regulated substances, but monitoring of its use in selected populations is warranted. Psychiatrists and physicians working in the penitentiary system should be aware of the addictive potential of quetiapine and adopt measures restricting its use.

Quetiapine Abuse Fourteen Years Later: Where Are We Now? A Systematic Review / Vento, A. E.; Kotzalidis, G. D.; Cacciotti, M.; Papanti, G. D.; Orsolini, L.; Rapinesi, C.; Savoja, V.; Calabro, G.; Del Casale, A.; Piacentino, D.; Caloro, M.; Girardi, P.; Schifano, F.. - In: SUBSTANCE USE & MISUSE. - ISSN 1082-6084. - 55:2(2019), pp. 304-313. [10.1080/10826084.2019.1668013]

Quetiapine Abuse Fourteen Years Later: Where Are We Now? A Systematic Review

Vento A. E.;Kotzalidis G. D.;Rapinesi C.;Savoja V.;Del Casale A.;Piacentino D.;Caloro M.;Girardi P.;Schifano F.
2019

Abstract

Background: Quetiapine, an atypical antipsychotic endowed with weak dopamine antagonist, potent 5-HT2A-blocking, partial 5-HT1A-agonist, anti-H1 histamine, adrenolytic, and sigma1 receptor agonist activities, since an original 2004 report is increasingly misused. Although some of its pharmacodynamics might explain some motives for voluptuary use, most of its actions are directed at setting-off those motives. Hence, it is possible that its popularity in special populations is due to the fact that the unpleasant or unwanted effects of addiction substances are somehow soothed by quetiapine. Currently, quetiapine is tested in substance use disorders, showing some promise, but it is likely to be misused in certain contexts. Objectives: To review the evidence for the use of quetiapine as addiction substance and investigate the characteristics of populations involved in such addiction. Methods: A systematic review of literature on various databases retrieved on September 7, 2018 87 records to comment. Results. We reviewed the evidence for quetiapine’s addictive potential in the light of its pharmacodynamics properties and presented two cases of recreational quetiapine use, by a 35-year old male patient with past addictive behavior and by a 50-year-old woman with major depressive disorder and conversion disorder. We found quetiapine to be abused mainly by addict populations and people with law involvement. Conclusions/Importance: There is no reason to include quetiapine among regulated substances, but monitoring of its use in selected populations is warranted. Psychiatrists and physicians working in the penitentiary system should be aware of the addictive potential of quetiapine and adopt measures restricting its use.
2019
Addiction; Dependence; Non-prescription use; Off-label use; Quetiapine; Substance Use Disorders
01 Pubblicazione su rivista::01a Articolo in rivista
Quetiapine Abuse Fourteen Years Later: Where Are We Now? A Systematic Review / Vento, A. E.; Kotzalidis, G. D.; Cacciotti, M.; Papanti, G. D.; Orsolini, L.; Rapinesi, C.; Savoja, V.; Calabro, G.; Del Casale, A.; Piacentino, D.; Caloro, M.; Girardi, P.; Schifano, F.. - In: SUBSTANCE USE & MISUSE. - ISSN 1082-6084. - 55:2(2019), pp. 304-313. [10.1080/10826084.2019.1668013]
File allegati a questo prodotto
File Dimensione Formato  
Vento_Quietapine_Abuse_2019.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.27 MB
Formato Adobe PDF
1.27 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1351524
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 11
social impact