In mammals, the transient receptor potential (TRP) channels family consists of six different families, namely TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipin), TRPP (polycystin), and TRPA (ankyrin), that are strictly connected with cancer cell proliferation, differentiation, cell death, angiogenesis, migration, and invasion. Changes in TRP channels' expression and function have been found to regulate cell proliferation and resistance or sensitivity of cancer cells to apoptotic-induced cell death, resulting in cancer-promoting effects or resistance to chemotherapy treatments. This review summarizes the data reported so far on the effect of targeting TRP channels in different types of cancer by using multiple TRP-specific agonists, antagonists alone, or in combination with classic chemotherapeutic agents, microRNA specifically targeting the TRP channels, and so forth, and the in vitro and in vivo feasibility evaluated in experimental models and in cancer patients. Considerable efforts have been made to fight cancer cells, and therapies targeting TRP channels seem to be the most promising strategy. However, more in-depth investigations are required to completely understand the role of TRP channels in cancer in order to design new, more specific, and valuable pharmacological tools.

Transient receptor potential cation channels in cancer therapy / Santoni, Giorgio; Maggi, Federica; Morelli, Maria Beatrice; Santoni, Matteo; Marinelli, Oliviero. - In: MEDICAL SCIENCES. - ISSN 2076-3271. - 7:12(2019). [10.3390/medsci7120108]

Transient receptor potential cation channels in cancer therapy

Maggi, Federica;Morelli, Maria Beatrice;
2019

Abstract

In mammals, the transient receptor potential (TRP) channels family consists of six different families, namely TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipin), TRPP (polycystin), and TRPA (ankyrin), that are strictly connected with cancer cell proliferation, differentiation, cell death, angiogenesis, migration, and invasion. Changes in TRP channels' expression and function have been found to regulate cell proliferation and resistance or sensitivity of cancer cells to apoptotic-induced cell death, resulting in cancer-promoting effects or resistance to chemotherapy treatments. This review summarizes the data reported so far on the effect of targeting TRP channels in different types of cancer by using multiple TRP-specific agonists, antagonists alone, or in combination with classic chemotherapeutic agents, microRNA specifically targeting the TRP channels, and so forth, and the in vitro and in vivo feasibility evaluated in experimental models and in cancer patients. Considerable efforts have been made to fight cancer cells, and therapies targeting TRP channels seem to be the most promising strategy. However, more in-depth investigations are required to completely understand the role of TRP channels in cancer in order to design new, more specific, and valuable pharmacological tools.
2019
chemotherapy resistance; transient receptor potential channels; tumor progression
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Transient receptor potential cation channels in cancer therapy / Santoni, Giorgio; Maggi, Federica; Morelli, Maria Beatrice; Santoni, Matteo; Marinelli, Oliviero. - In: MEDICAL SCIENCES. - ISSN 2076-3271. - 7:12(2019). [10.3390/medsci7120108]
File allegati a questo prodotto
File Dimensione Formato  
Santoni_Transient-receptor_2019.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 368.61 kB
Formato Adobe PDF
368.61 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1348283
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 25
  • ???jsp.display-item.citation.isi??? ND
social impact