Whether mechanical ventilation (MV) induces neurotoxicity that can trigger or accelerate chronic cognitive disorders is controversial [1, 2]. The relationship between MV and neurocognitive impairment—that persisted at hospital discharge and at 1-year follow up—was first reported in 1999 in MV-treated ARDS patients [3]. Since then, several preclinical and clinical studies have investigated the mechanisms, localization, and timing of brain damage induced by MVand possible preventive/therapeutic strategies.
Harmful effects of mechanical ventilation on neurocognitive functions / Bilotta, F.; Giordano, G.; Sergi, P. G.; Pugliese, F.. - In: CRITICAL CARE. - ISSN 1466-609X. - 23:1(2019). [10.1186/s13054-019-2546-y]
Harmful effects of mechanical ventilation on neurocognitive functions
Bilotta F.
Conceptualization
;Giordano G.Membro del Collaboration Group
;Pugliese F.Validation
2019
Abstract
Whether mechanical ventilation (MV) induces neurotoxicity that can trigger or accelerate chronic cognitive disorders is controversial [1, 2]. The relationship between MV and neurocognitive impairment—that persisted at hospital discharge and at 1-year follow up—was first reported in 1999 in MV-treated ARDS patients [3]. Since then, several preclinical and clinical studies have investigated the mechanisms, localization, and timing of brain damage induced by MVand possible preventive/therapeutic strategies.| File | Dimensione | Formato | |
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