This work presents the development of a compact optoelectronic device suitable for on-chip detection of fluorescent molecules. In order to obtain a highly integrated device, a long-pass multi-dielectric filter has been integrated with thin film amorphous silicon photosensors on a single glass substrate. Filter rejects the excitation light, allowing the reduction of the distance between the source and the fluorescent site and avoiding the use of external optical component. The compatibility of the technological processes determined the materials and the temporal sequence of the device fabrication. The developed device has been designed for the fluorescence detection of ruthenium complex-based molecules and tested, as a proof of concept, for the detection of double-stranded DNA down to 0.5 ng. Results demonstrate the correct operation of the integrated system in both rejecting the excitation light and in detecting the fluorescent signal, demonstrating the suitability of this optoelectronic platform in practical biomedical applications.

Integrated optoelectronic device for detection of fluorescent molecules / Lovecchio, Nicola; Costantini, Francesca; Parisi, Emanuele; Nardecchia, Marco; Tucci, Mario; Nascetti, Augusto; de Cesare, Giampiero; Caputo, Domenico. - In: IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS. - ISSN 1932-4545. - 12:6(2018), pp. 1337-1344. [10.1109/TBCAS.2018.2880922]

Integrated optoelectronic device for detection of fluorescent molecules

Lovecchio, Nicola;Costantini, Francesca;Nardecchia, Marco;Nascetti, Augusto;de Cesare, Giampiero;Caputo, Domenico
2018

Abstract

This work presents the development of a compact optoelectronic device suitable for on-chip detection of fluorescent molecules. In order to obtain a highly integrated device, a long-pass multi-dielectric filter has been integrated with thin film amorphous silicon photosensors on a single glass substrate. Filter rejects the excitation light, allowing the reduction of the distance between the source and the fluorescent site and avoiding the use of external optical component. The compatibility of the technological processes determined the materials and the temporal sequence of the device fabrication. The developed device has been designed for the fluorescence detection of ruthenium complex-based molecules and tested, as a proof of concept, for the detection of double-stranded DNA down to 0.5 ng. Results demonstrate the correct operation of the integrated system in both rejecting the excitation light and in detecting the fluorescent signal, demonstrating the suitability of this optoelectronic platform in practical biomedical applications.
2018
amorphous silicon photosensors; DNA detection; fluorescence; interferential filters.
01 Pubblicazione su rivista::01a Articolo in rivista
Integrated optoelectronic device for detection of fluorescent molecules / Lovecchio, Nicola; Costantini, Francesca; Parisi, Emanuele; Nardecchia, Marco; Tucci, Mario; Nascetti, Augusto; de Cesare, Giampiero; Caputo, Domenico. - In: IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS. - ISSN 1932-4545. - 12:6(2018), pp. 1337-1344. [10.1109/TBCAS.2018.2880922]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1212613
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