Regional CBF (rCBF) and regional cerebral blood volume (rCBV) were evaluated by N,N,N'-trimethyl-N'-(2)-hydroxy-3-methyl-5-[123I] iodobenzyl-1,3-propanediamine-2 HCl- and 99mTC-labeled red blood cells, respectively, and single-photon emission computerized tomography (SPECT) in a patient with focal cerebral ischemia. Sequential transmission computerized tomography (TCT) and SPECT functional data were compared with clinical findings to monitor the pathophysiological events occurring in stroke. A lack of correlation between rCBF-rCBV distributions and blood-brain barrier (BBB) breakdown was found in the acute phase. In the face of more prolonged alteration of BBB, as seen by TCT enhancement, a rapid evolution of transient phenomena such as luxury perfusion was shown by SPECT studies. Follow-up of the patient demonstrated a correlation between the neurological recovery and a parallel relative improvement of the cerebral perfusion.

Sequential assessment of regional blood flow, regional cerebral blood volume, and blood-brain barrier in focal cerebral ischemia: a case report / DI PIERO, Vittorio; Perani, D; Savi, A; Gerundini, P; Lenzi, Gian Luigi; Fazio, F.. - In: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. - ISSN 0271-678X. - STAMPA. - 6:(1986), pp. 379-384.

Sequential assessment of regional blood flow, regional cerebral blood volume, and blood-brain barrier in focal cerebral ischemia: a case report

DI PIERO, Vittorio;LENZI, Gian Luigi;
1986

Abstract

Regional CBF (rCBF) and regional cerebral blood volume (rCBV) were evaluated by N,N,N'-trimethyl-N'-(2)-hydroxy-3-methyl-5-[123I] iodobenzyl-1,3-propanediamine-2 HCl- and 99mTC-labeled red blood cells, respectively, and single-photon emission computerized tomography (SPECT) in a patient with focal cerebral ischemia. Sequential transmission computerized tomography (TCT) and SPECT functional data were compared with clinical findings to monitor the pathophysiological events occurring in stroke. A lack of correlation between rCBF-rCBV distributions and blood-brain barrier (BBB) breakdown was found in the acute phase. In the face of more prolonged alteration of BBB, as seen by TCT enhancement, a rapid evolution of transient phenomena such as luxury perfusion was shown by SPECT studies. Follow-up of the patient demonstrated a correlation between the neurological recovery and a parallel relative improvement of the cerebral perfusion.
1986
01 Pubblicazione su rivista::01a Articolo in rivista
Sequential assessment of regional blood flow, regional cerebral blood volume, and blood-brain barrier in focal cerebral ischemia: a case report / DI PIERO, Vittorio; Perani, D; Savi, A; Gerundini, P; Lenzi, Gian Luigi; Fazio, F.. - In: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. - ISSN 0271-678X. - STAMPA. - 6:(1986), pp. 379-384.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/115755
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