OBJECTIVES: Culprit plaque characteristics in young patients who experience an Acute Coronary Syndrome (ACS) evaluated by OCT (Optical Coherence Tomography) have to be defined. The OCT-FORMIDABLE is a multicentre retrospective registry enrolling consecutive patients with ACS who performed OCT in 9 European centres. METHODS: Patients were divided in two groups according to age at presentation: juvenile-ACS (age ≤ 50 years) and not juvenile-ACS (age > 50 years). Primary end-point was the prevalence of plaque rupture (PR). Secondary end point was the prevalence of thin cap fibro atheroma (TCFA), fibrocalcific and fibrotic plaque. RESULTS: 285 patients were included, 71 (24.9%) in juvenile-ACS group and 215 (75.1%) in not juvenile-ACS group. Younger patients showed a trend for a higher prevalence of TCFA (70 vs. 58%, P = 0.06) and thrombus presence (62 vs. 51%, P = 0.1), while no statistical difference concerning PR (70 vs. 64%, P = 0.29). Of interest patients younger that 35 years showed a higher prevalence of PR compared to patients aged between 35 and 45 or 45 and 50 years (100 vs. 72 vs. 55%, P = 0.03). Culprit plaque in juvenile-ACS group showed more frequently a reduced mean cap thickness (119 ± 66 vs. 155 ± 95 nm, P = 0.05) and less frequently fibrotic (32 vs. 57%, P < 0.001) or fibrocalcific (17 vs. 36%, P = 0.003) characteristics. CONCLUSION:young patients with ACS show a trend for a higher prevalence of culprit PR, a thinner cap and less fibrotic or fibrocalcific components.

Culprit plaque characteristics in younger versus older patients with acute coronary syndromes. an optical coherence tomography study from the FORMIDABLE registry / Barbero, Umberto; Scacciatella, Paolo; Iannaccone, Mario; D'Ascenzo, Fabrizio; Niccoli, Giampaolo; Colombo, Francesco; Ugo, Fabrizio; Colangelo, Salvatore; Mancone, Massimo; Calcagno, Simone; Sardella, Gennaro; Amabile, Nicolas; Motreff, Pascal; Toutouzas, Konstantinos; Garbo, Roberto; Tamburino, Corrado; Montefusco, Antonio; Omedã, Pierluigi; Moretti, Claudio; D'Amico, Maurizio; Souteyrand, Geraud; Gaita, Fiorenzo; Templin, Christian. - In: CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. - ISSN 1522-1946. - ELETTRONICO. - 92:1(2017), pp. E1-E8. [10.1002/ccd.27172]

Culprit plaque characteristics in younger versus older patients with acute coronary syndromes. an optical coherence tomography study from the FORMIDABLE registry

COLANGELO, SALVATORE;Mancone, Massimo;Simone, Calcagno;Sardella, Gennaro;Moretti, Claudio;D'AMICO, Maurizio;
2017

Abstract

OBJECTIVES: Culprit plaque characteristics in young patients who experience an Acute Coronary Syndrome (ACS) evaluated by OCT (Optical Coherence Tomography) have to be defined. The OCT-FORMIDABLE is a multicentre retrospective registry enrolling consecutive patients with ACS who performed OCT in 9 European centres. METHODS: Patients were divided in two groups according to age at presentation: juvenile-ACS (age ≤ 50 years) and not juvenile-ACS (age > 50 years). Primary end-point was the prevalence of plaque rupture (PR). Secondary end point was the prevalence of thin cap fibro atheroma (TCFA), fibrocalcific and fibrotic plaque. RESULTS: 285 patients were included, 71 (24.9%) in juvenile-ACS group and 215 (75.1%) in not juvenile-ACS group. Younger patients showed a trend for a higher prevalence of TCFA (70 vs. 58%, P = 0.06) and thrombus presence (62 vs. 51%, P = 0.1), while no statistical difference concerning PR (70 vs. 64%, P = 0.29). Of interest patients younger that 35 years showed a higher prevalence of PR compared to patients aged between 35 and 45 or 45 and 50 years (100 vs. 72 vs. 55%, P = 0.03). Culprit plaque in juvenile-ACS group showed more frequently a reduced mean cap thickness (119 ± 66 vs. 155 ± 95 nm, P = 0.05) and less frequently fibrotic (32 vs. 57%, P < 0.001) or fibrocalcific (17 vs. 36%, P = 0.003) characteristics. CONCLUSION:young patients with ACS show a trend for a higher prevalence of culprit PR, a thinner cap and less fibrotic or fibrocalcific components.
2017
acute coronary syndrome; Ddug eluting stent; juvenile; optical coherence tomography; young; radiology, nuclear medicine and imaging; cardiology and cardiovascular medicine
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Culprit plaque characteristics in younger versus older patients with acute coronary syndromes. an optical coherence tomography study from the FORMIDABLE registry / Barbero, Umberto; Scacciatella, Paolo; Iannaccone, Mario; D'Ascenzo, Fabrizio; Niccoli, Giampaolo; Colombo, Francesco; Ugo, Fabrizio; Colangelo, Salvatore; Mancone, Massimo; Calcagno, Simone; Sardella, Gennaro; Amabile, Nicolas; Motreff, Pascal; Toutouzas, Konstantinos; Garbo, Roberto; Tamburino, Corrado; Montefusco, Antonio; Omedã, Pierluigi; Moretti, Claudio; D'Amico, Maurizio; Souteyrand, Geraud; Gaita, Fiorenzo; Templin, Christian. - In: CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. - ISSN 1522-1946. - ELETTRONICO. - 92:1(2017), pp. E1-E8. [10.1002/ccd.27172]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1152307
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