Wearing-off refers to the predictable worsening of motor and sometimes non-motor symptoms of Parkinson's disease occurring at the end of levodopa dose that improves with the next drug dose. Here, we investigated the efficacy of rasagiline on executive functions at the end of levodopa dose in patients displaying symptoms of wearing-off. Rasagiline was well-tolerated and produced a significant improvement at the Frontal Assessment Battery, together with improvement of motor symptoms at the end of levodopa dose. These results suggest that treatment of motor symptoms of wearing-off with rasagiline may be accompanied by improvement of executive functions, and further support the need for optimizing dopamine replacement therapy in fluctuating Parkinson's disease patients.

Rasagiline for dysexecutive symptoms during wearing-off in parkinson's disease: a pilot study / Rinaldi, D; Assogna, F; Sforza, M; Tagliente, S; Pontieri, Fe. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - STAMPA. - 39:1(2018), pp. 141-143. [10.1007/s10072-017-3123-2]

Rasagiline for dysexecutive symptoms during wearing-off in parkinson's disease: a pilot study.

Rinaldi D;Sforza M;Tagliente S;Pontieri FE
2018

Abstract

Wearing-off refers to the predictable worsening of motor and sometimes non-motor symptoms of Parkinson's disease occurring at the end of levodopa dose that improves with the next drug dose. Here, we investigated the efficacy of rasagiline on executive functions at the end of levodopa dose in patients displaying symptoms of wearing-off. Rasagiline was well-tolerated and produced a significant improvement at the Frontal Assessment Battery, together with improvement of motor symptoms at the end of levodopa dose. These results suggest that treatment of motor symptoms of wearing-off with rasagiline may be accompanied by improvement of executive functions, and further support the need for optimizing dopamine replacement therapy in fluctuating Parkinson's disease patients.
2018
cognition; frontal assessment battery; parkinson’s disease; rasagiline; wearing-off
01 Pubblicazione su rivista::01a Articolo in rivista
Rasagiline for dysexecutive symptoms during wearing-off in parkinson's disease: a pilot study / Rinaldi, D; Assogna, F; Sforza, M; Tagliente, S; Pontieri, Fe. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - STAMPA. - 39:1(2018), pp. 141-143. [10.1007/s10072-017-3123-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1118641
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