Gene-encoded peptide antibiotics have been isolated from plants, animals and microbes. Their protective role has been related to innate immunity, which has gradually become accepted across the biomedical community, The evidence for the immune function of peptide antibiotics has been convincingly demonstrated by a combination of both in vitro and in vivo data for plants and insects, but for vertebrates in vivo data are scarce. Using frogs as model systems, it has been shown that the genes for antibacterial peptides are down-regulated by glucocorticoids, while I kappa B alpha is clearly up-regulated, Experimental infections with frog bacteria have shown that the normal capacity to control the natural flora is lost after treatment with glucocorticoids, A low-specificity immune mechanism is cost-effective, something that may have been of importance during animal evolution. (C) 1998 Federation of European Biochemical Societies.

Gene-encoded peptide antibiotics and innate immunity. Do 'animalcules' have defence budgets? / Barra, Donatella; Simmaco, Maurizio; H. G., Boman. - In: FEBS LETTERS. - ISSN 0014-5793. - 430:1-2(1998), pp. 130-134. [10.1016/s0014-5793(98)00494-3]

Gene-encoded peptide antibiotics and innate immunity. Do 'animalcules' have defence budgets?

BARRA, Donatella;SIMMACO, Maurizio;
1998

Abstract

Gene-encoded peptide antibiotics have been isolated from plants, animals and microbes. Their protective role has been related to innate immunity, which has gradually become accepted across the biomedical community, The evidence for the immune function of peptide antibiotics has been convincingly demonstrated by a combination of both in vitro and in vivo data for plants and insects, but for vertebrates in vivo data are scarce. Using frogs as model systems, it has been shown that the genes for antibacterial peptides are down-regulated by glucocorticoids, while I kappa B alpha is clearly up-regulated, Experimental infections with frog bacteria have shown that the normal capacity to control the natural flora is lost after treatment with glucocorticoids, A low-specificity immune mechanism is cost-effective, something that may have been of importance during animal evolution. (C) 1998 Federation of European Biochemical Societies.
1998
amphibian; glucocorticoid; innate immunity; nf kappa b-i kappa b; nfκb-iκb; peptide antibiotic; rana esculenta
01 Pubblicazione su rivista::01a Articolo in rivista
Gene-encoded peptide antibiotics and innate immunity. Do 'animalcules' have defence budgets? / Barra, Donatella; Simmaco, Maurizio; H. G., Boman. - In: FEBS LETTERS. - ISSN 0014-5793. - 430:1-2(1998), pp. 130-134. [10.1016/s0014-5793(98)00494-3]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/10821
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 54
  • ???jsp.display-item.citation.isi??? 51
social impact