Social and occupational impairments are present in the schizophrenia prodrome, and poor social functioning predicts transition to psychosis in Ultra-High Risk (UHR) individuals. We aimed to: 1) validate the Italian version of the Global Functioning: Social (GF: S) and Global Functioning: Role (GF: S) scales; 2) evaluate their association with UHR criteria. Participants were 12-21-years-old (age, mean=15.2, standard deviation=2.1, male/female ratio=117/120) nonpsychotic help-seekers, meeting (N=39) or not (N=198) UHR criteria. Inter-rater reliability was excellent for both scales, which also showed good to excellent concurrent validity, as measured by correlation with Global Assessment of Functioning (GAF) scores. Furthermore, GF:S and GF: R were able to discriminate between UHRs and non-UHRs, with UHRs having lower current scores. After adjusting for current GAF scores, only current GF:S scores independently differentiated UHR from non-UHR (OR=1.33, 95%CI: 1.02-1.75, p=0.033). Finally, UHR participants showed a steeper decrease from highest GF:S and GF: R scores in the past year to their respective current scores, but not from highest past year GAF scores to current scores. GF:S/GS: R scores were not affected by age or sex. GF:S/GF: R are useful functional level and outcome measures, having the advantage over the GAF to not confound functioning with symptom severity. Additionally, the GF:S may be helpful in identifying UHR individuals.

Impairment in Social Functioning differentiates youth meeting ultra-high risk for psychosis criteria from other mental health help-seekers. A validation of the Italian version of the Global Functioning: Social and Global Functioning: Role scales / Lo Cascio, Nella; Curto, Martina; Pasqualetti, Patrizio; Lindau, Juliana Fortes; Girardi, Nicoletta; Saba, Riccardo; Brandizzi, Martina; Monducci, Elena; Masillo, Alice; Colafrancesco, Giada; Solfanelli, Andrea; De Crescenzo, Franco; Kotzalidis, Georgios D.; Dario, Claudia; Ferrara, Mauro; Vicari, Stefano; Girardi, Paolo; Auther, Andrea M.; Cornblatt, Barbara A.; Correll, Christoph U.; Fiori Nastro, Paolo. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 253:(2017), pp. 296-302. [10.1016/j.psychres.2017.04.008]

Impairment in Social Functioning differentiates youth meeting ultra-high risk for psychosis criteria from other mental health help-seekers. A validation of the Italian version of the Global Functioning: Social and Global Functioning: Role scales

Lo Cascio, Nella;Curto, Martina
;
Pasqualetti, Patrizio;Girardi, Nicoletta;Saba, Riccardo;Brandizzi, Martina;Monducci, Elena;Masillo, Alice;Colafrancesco, Giada;Solfanelli, Andrea;Dario, Claudia;Ferrara, Mauro;Girardi, Paolo;Fiori Nastro, Paolo
2017

Abstract

Social and occupational impairments are present in the schizophrenia prodrome, and poor social functioning predicts transition to psychosis in Ultra-High Risk (UHR) individuals. We aimed to: 1) validate the Italian version of the Global Functioning: Social (GF: S) and Global Functioning: Role (GF: S) scales; 2) evaluate their association with UHR criteria. Participants were 12-21-years-old (age, mean=15.2, standard deviation=2.1, male/female ratio=117/120) nonpsychotic help-seekers, meeting (N=39) or not (N=198) UHR criteria. Inter-rater reliability was excellent for both scales, which also showed good to excellent concurrent validity, as measured by correlation with Global Assessment of Functioning (GAF) scores. Furthermore, GF:S and GF: R were able to discriminate between UHRs and non-UHRs, with UHRs having lower current scores. After adjusting for current GAF scores, only current GF:S scores independently differentiated UHR from non-UHR (OR=1.33, 95%CI: 1.02-1.75, p=0.033). Finally, UHR participants showed a steeper decrease from highest GF:S and GF: R scores in the past year to their respective current scores, but not from highest past year GAF scores to current scores. GF:S/GS: R scores were not affected by age or sex. GF:S/GF: R are useful functional level and outcome measures, having the advantage over the GAF to not confound functioning with symptom severity. Additionally, the GF:S may be helpful in identifying UHR individuals.
2017
Adolescents; psychosis; rating scales; reliability; social functioning; validation; psychiatry and mental Health; biological psychiatry
01 Pubblicazione su rivista::01a Articolo in rivista
Impairment in Social Functioning differentiates youth meeting ultra-high risk for psychosis criteria from other mental health help-seekers. A validation of the Italian version of the Global Functioning: Social and Global Functioning: Role scales / Lo Cascio, Nella; Curto, Martina; Pasqualetti, Patrizio; Lindau, Juliana Fortes; Girardi, Nicoletta; Saba, Riccardo; Brandizzi, Martina; Monducci, Elena; Masillo, Alice; Colafrancesco, Giada; Solfanelli, Andrea; De Crescenzo, Franco; Kotzalidis, Georgios D.; Dario, Claudia; Ferrara, Mauro; Vicari, Stefano; Girardi, Paolo; Auther, Andrea M.; Cornblatt, Barbara A.; Correll, Christoph U.; Fiori Nastro, Paolo. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 253:(2017), pp. 296-302. [10.1016/j.psychres.2017.04.008]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1022110
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