Despite an intense interest and a remarkable number of studies on the subject, the relationships between thermostability and (primary, secondary and tertiary) structure of proteins are still not fully understood. Here, comparing the protein density - defined by the ratio between the residue number and protein excluded volume - for a set of thermophilic/mesophilic pairs, we provide evidence that this property is connected to the optimal growth temperature. In particular, our results indicate that thermophilic proteins have - in general - a lower density with respect to the mesophilic counterparts, being such a correlation more pronounced for optimal growth temperature differences greater than 40° C. The effect of the protein thermostability changes on the molecular shape is also presented.

Density discriminates between thermophilic and mesophilic proteins / Amadei, Andrea; Del Galdo, Sara; D'Abramo, Marco. - In: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. - ISSN 0739-1102. - ELETTRONICO. - 36:12(2018), pp. 3265-3273. [10.1080/07391102.2017.1385537]

Density discriminates between thermophilic and mesophilic proteins

D'Abramo, Marco
2018

Abstract

Despite an intense interest and a remarkable number of studies on the subject, the relationships between thermostability and (primary, secondary and tertiary) structure of proteins are still not fully understood. Here, comparing the protein density - defined by the ratio between the residue number and protein excluded volume - for a set of thermophilic/mesophilic pairs, we provide evidence that this property is connected to the optimal growth temperature. In particular, our results indicate that thermophilic proteins have - in general - a lower density with respect to the mesophilic counterparts, being such a correlation more pronounced for optimal growth temperature differences greater than 40° C. The effect of the protein thermostability changes on the molecular shape is also presented.
2018
mesophilic and thermophilic proteins; protein density; protein structure; thermostability
01 Pubblicazione su rivista::01a Articolo in rivista
Density discriminates between thermophilic and mesophilic proteins / Amadei, Andrea; Del Galdo, Sara; D'Abramo, Marco. - In: JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. - ISSN 0739-1102. - ELETTRONICO. - 36:12(2018), pp. 3265-3273. [10.1080/07391102.2017.1385537]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1010652
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