Sfoglia per Autore SILVESTRI, Romano
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent
2023 Nalli, Marianna; Di Magno, Laura; Wen, Yichao; Liu, Xin; D’Ambrosio, Michele; Puxeddu, Michela; Parisi, Anastasia; Sebastiani, Jessica; Sorato, Andrea; Coluccia, Antonio; Ripa, Silvia; Di Pastena, Fiorella; Capelli, Davide; Montanari, Roberta; Masci, Domiziana; Urbani, Andrea; Naro, Chiara; Sette, Claudio; Orlando, Viviana; D’Angelo, Sara; Biagioni, Stefano; Bigogno, Chiara; Dondio, Giulio; Pastore, Arianna; Stornaiuolo, Mariano; Canettieri, Gianluca; Liu, Te; Silvestri, Romano; La Regina, Giuseppe
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells
2023 Masci, Domiziana; Puxeddu, Michela; Di Magno, Laura; D'Ambrosio, Michele; Parisi, Anastasia; Nalli, Marianna; Bai, Ruoli; Coluccia, Antonio; Sciò, Pietro; Orlando, Viviana; D'Angelo, Sara; Biagioni, Stefano; Urbani, Andrea; Hamel, Ernest; Nocentini, Alessio; Filiberti, Serena; Turati, Marta; Ronca, Roberto; Kopecka, Joanna; Riganti, Chiara; Fionda, Cinzia; Bordone, Rosa; Della Rocca, Giorgia; Canettieri, Gianluca; Supuran, Claudiu T; Silvestri, Romano; La Regina, Giuseppe
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo
2023 Sebastiani, J.; Puxeddu, M.; Nalli, M.; Bai, R.; Altieri, L.; Rovella, P.; Gaudio, E.; Trisciuoglio, D.; Spriano, F.; Lavia, P.; Fionda, C.; Masci, D.; Urbani, A.; Bigogno, C.; Dondio, G.; Hamel, E.; Bertoni, F.; Silvestri, R.; La Regina, G.
Recent advances in drug discovery for Triple-Negative Breast cancer treatment
2023 Masci, Domiziana; Naro, Chiara; Puxeddu, Michela; Urbani, Andrea; Sette, Claudio; La Regina, Giuseppe; Silvestri, Romano
Toll-like receptor 4-dependent platelet-related thrombosis in SARS-CoV-2 infection
2023 Carnevale, Roberto; Cammisotto, Vittoria; Bartimoccia, Simona; Nocella, Cristina; Castellani, Valentina; Bufano, Marianna; Loffredo, Lorenzo; Sciarretta, Sebastiano; Frati, Giacomo; Coluccia, Antonio; Silvestri, Romano; Ceccarelli, Giancarlo; Oliva, Alessandra; Venditti, Mario; Pugliese, Francesco; Maria Mastroianni, Claudio; Turriziani, Ombretta; Leopizzi, Martina; D'Amati, Giulia; Pignatelli, Pasquale; Violi, Francesco
Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands
2023 Dvorácskó, Szabolcs; Dimmito, Marilisa Pia; Sebastiani, Jessica; La Regina, Giuseppe; Silvestri, Romano; Pieretti, Stefano; Stefanucci, Azzurra; Tömböly, Csaba; Mollica, Adriano
A Novel Validated UHPLC Method for the Estimation of Rosuvastatin and Its Complete Impurity Profile in Tablet Formulations
2023 Mammone, F. R.; Zanitti, L.; Puxeddu, M.; La Regina, G.; Silvestri, R.; Borioni, A.; Cirilli, R.
Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators
2023 Bufano, Marianna; Puxeddu, Michela; Nalli, Marianna; La Regina, Giuseppe; Toto, Angelo; Liberati, Francesca Romana; Paone, Alessio; Cutruzzolà, Francesca; Masci, Domiziana; Bigogno, Chiara; Dondio, Giulio; Silvestri, Romano; Gianni, Stefano; Coluccia, Antonio
EFFICACY AND SAFETY OF A NOVEL FOOD SUPPLEMENT IN THE TREATMENT OF FUNCTIONAL DYSPEPSIA: A PILOT OPEN STUDY
2022 Innocenti, Matteo; Silvestri, Romano; Ceracchi, Maurizio; Silvestrini, Bruno
Novel quinoline derivatives and uses thereof
2022 Minucci, Saverio; De Wulf Peter Arthur, Irene; Romanenghi, Mauro; Cazzoli, Riccardo; Damizia, Michela; Silvestri, Romano; La Regina, Giuseppe; Coluccia, Antonio
Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor
2022 Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe La; Puxeddu, Michela; Toto, Angelo; Paone, Alessio; Bouzidi, Amani; Musto, Giorgia; Badolati, Nadia; Orlando, Viviana; Biagioni, Stefano; Masci, Domiziana; Cantatore, Chiara; Cirilli, Roberto; Cutruzzolà, Francesca; Gianni, Stefano; Stornaiuolo, Mariano; Silvestri, Romano
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment
2022 Di Magno, L; Coluccia, A; Bufano, M; Ripa, S; La Regina, G; Nalli, M; Di Pastena, F; Canettieri, G; Silvestri, R; Frati, L
Emerging Direct Targeting β-Catenin Agents
2022 Nalli, M.; Masci, D.; Urbani, A.; La Regina, G.; Silvestri, R.
Single-run chemo- and enantio-selective high-performance liquid chromatography separation of tramadol and its principal metabolite, O-desmethyltramadol, using a chlorinated immobilized amylose-based chiral stationary phase under multimodal elution conditions
2022 Cantatore, C.; La Regina, G.; Ferretti, R.; Silvestri, R.; Cirilli, R.
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor
2022 Puxeddu, Michela; Wu, Jianchao; Bai, Ruoli; D’Ambrosio, Michele; Nalli, Marianna; Coluccia, Antonio; Manetto, Simone; Ciogli, Alessia; Masci, Domiziana; Urbani, Andrea; Fionda, Cinzia; Coni, Sonia; Bordone, Rosa; Canettieri, Gianluca; Bigogno, Chiara; Dondio, Giulio; Hamel, Ernest; Liu, Te; Silvestri, Romano; LA REGINA, Giuseppe
Modulating undruggable targets to overcome cancer therapy resistance
2022 Passirani, C.; Vessieres, A.; La Regina, G.; Link, W.; Silvestri, R.
Exploring CCRL2 chemerin binding using accelerated molecular dynamics
2022 Bufano, M.; Laffranchi, M.; Sozzani, S.; Raimondo, D.; Silvestri, R.; Coluccia, A.
A METHOD TO MEASURE THE BARRIER EFFECT OF DRUGS AND ITS APPLICATION IN THE STUDY OF HYDROLYZED COLLAGEN
2021 Silvestrini, Bruno; Silvestri, Romano; Cheng, C. Y.; Ceracchi, Maurizio; Innocenti, Matteo
Novel quinoline derivatives and uses thereof
2021 Silvestri, Romano; La Regina, Giuseppe; Coluccia, Antonio; Minucci, Saverio; De Wulf, Peter Arthur Irene
Emerging therapeutic agents for colorectal cancer
2021 Nalli, M.; Puxeddu, M.; La Regina, G.; Gianni, S.; Silvestri, R.
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
2021 Puxeddu, M.; Shen, H.; Bai, R.; Coluccia, A.; Bufano, M.; Nalli, M.; Sebastiani, J.; Brancaccio, D.; Da Pozzo, E.; Tremolanti, C.; Martini, C.; Orlando, V.; Biagioni, S.; Sinicropi, M. S.; Ceramella, J.; Iacopetta, D.; Coluccia, A. M. L.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G.
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme
2021 Daniele, S.; La Pietra, V.; Piccarducci, R.; Pietrobono, D.; Cavallini, C.; D'Amore, V. M.; Cerofolini, L.; Giuntini, S.; Russomanno, P.; Puxeddu, M.; Nalli, M.; Pedrini, M.; Fragai, M.; Luchinat, C.; Novellino, E.; Taliani, S.; La Regina, G.; Silvestri, R.; Martini, C.; Marinelli, L.
Discovery of a novel class of norovirus inhibitors with high barrier of resistance
2021 Van Dycke, J.; Puxeddu, M.; La Regina, G.; Mastrangelo, E.; Tarantino, D.; Rymenants, J.; Sebastiani, J.; Nalli, M.; Matthijnssens, J.; Neyts, J.; Silvestri, R.; Rocha-Pereira, J.
Enantiomerization barrier of 1-[2-(2-methyl-2-methoxycarbonylacetamido) benzenesulfonyl]-1h-pyrrole studied by enantioselective dynamic HPLC, classical off column technique and computational approach
2021 Buonsenso, Fabio; Cirilli, Roberto; Silvestri, Romano; Pierini, Marco
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
2021 Nardella, Caterina; Visconti, Lorenzo; Malagrinò, Francesca; Pagano, Livia; Bufano, Marianna; Nalli, Marianna; Coluccia, Antonio; La Regina, Giuseppe; Silvestri, Romano; Gianni, Stefano; Toto, Angelo
RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota
2021 Liu, T.; Wu, J.; Han, C.; Gong, Z.; La Regina, G.; Chen, J.; Dou, F.; Silvestri, R.; Chen, C.; Yu, Z.
RS4651 suppresses lung fibroblast activation via the TGF-β1/SMAD signalling pathway
2021 Li, S.; Xu, A.; Li, Y.; Tan, C.; La Regina, G.; Silvestri, R.; Wang, H.; Qi, W.
Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage
2020 Coluccia, A.; Puxeddu, M.; Nalli, M.; Wei, C. K.; Wu, Y. H.; Mastrangelo, E.; Elamin, T.; Tarantino, D.; Bugert, J. J.; Schreiner, B.; Nolte, J.; Schwarze, F.; La Regina, G.; Lee, J. C.; Silvestri, R.
Sulfonamide inhibitors of beta-catenin signaling as anticancer agents with different output on c-Myc
2020 DI MAGNO, Laura; DI PASTENA, Fiorella; Puxeddu, Michela; LA REGINA, Giuseppe; Coluccia, Antonio; Ciogli, Alessia; Manetto, Simone; Maroder, Marella; Canettieri, Gianluca; Silvestri, Romano; Nalli, Marianna
Discovery of new 1,1'-biphenyl-4-sulfonamides as selective subnanomolar human carbonic anhydrase II inhibitors
2020 La Regina, G.; Puxeddu, M.; Nalli, M.; Vullo, D.; Gratteri, P.; Supuran, C. T.; Nocentini, A.; Silvestri, R.
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains
2020 Nalli, M.; Armijos Rivera, J. I.; Masci, D.; Coluccia, A.; Badia, R.; Riveira-Muñoz, E.; Brambilla, A.; Cinquina, E.; Turriziani, O.; Falasca, F.; Catalano, M.; Limatola, C.; Esté, J. A.; Maga, G.; Silvestri, R.; Crespan, E.; La Regina, G.
HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53
2020 Capdevielle, Caroline; Desplat, Angelique; Charpentier, Justine; Sagliocco, Francis; Thiebaud, Pierre; Theze, Nadine; Fedou, Sandrine; Hooks, Katarzyna B.; Silvestri, Romano; Guyonnet-Duperat, Veronique; Petrel, Melina; Raymond, Anne-Aurelie; Dupuy, Jean-William; Grosset, Christophe F.; Hagedorn, Martin
Selenotriapine - an isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors
2020 Filipović, N. R.; Bjelogrlić, S. K.; Pelliccia, S.; Jovanović, V. B.; Kojić, M.; Senćanski, M.; La Regina, G.; Silvestri, R.; Muller, C. D.; Todorović, T. R.
Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites
2020 Scala, R.; Di Matteo, A.; Coluccia, A.; Lo Sciuto, A.; Federici, L.; Travaglini-Allocatelli, C.; Visca, P.; Silvestri, R.; Imperi, F.
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
2020 Puxeddu, M.; Shen, H.; Bai, R.; Coluccia, A.; Nalli, M.; Mazzoccoli, C.; Da Pozzo, E.; Cavallini, C.; Martini, C.; Orlando, V.; Biagioni, S.; Mazzoni, C.; Coluccia, A. M. L.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G.
Targeting the interaction between the SH3 domain of Grb2 and Gab2
2020 Malagrinò, Francesca; Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe; Puxeddu, Michela; Toto, Angelo; Visconti, Lorenzo; Paone, Alessio; Magnifico, Maria Chiara; Troilo, Francesca; Cutruzzolà, Francesca; Silvestri, Romano; Gianni, Stefano
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
2020 Bufano, M.; Laudette, M.; Blondeau, J. -P.; Lezoualc'H, F.; Nalli, M.; Silvestri, R.; Brancale, A.; Coluccia, A.
Design, synthesis and discovery of novel N,N'-carbazoyl-aryl-urea inhibitors of Zika NS5 methyltransferase and virus replication.
2020 Spizzichino, S; Mattedi, G; Lauder, K; Valle, C; Aouadi, W; Canard, B; Decroly, E; Kaptein, Sjf; Neyts, J; Graham, C; Sule, Z; Barlow, Dj; Silvestri, R; Castagnolo, D.
First in class pdz1 targeting NHERF1 inhibitors as anticancer agents
2019 LA REGINA, Giuseppe; Naccarato, Valentina; Puxeddu, Michela; Bufano, Marianna; Nalli, Marianna; Coluccia, Antonio; Silvestri, Romano
Small molecule inhibitors of kdm5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B
2019 La Regina, G.; Naccarato, V.; Masci, D.; Puxeddu, M.; Nalli, M.; Coluccia, A.; Negri, R.; Silvestri, R.
New anti-cancer agents through an interaction with tubulin
2019 La Regina, G; Coluccia, A; Naccarato, V; Silvestri, R.
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress
2019 Laudette, Marion; Coluccia, Antonio; Sainte-Marie, Yannis; Solari, Andrea; Fazal, Loubina; Sicard, Pierre; Silvestri, Romano; Mialet-Perez, Jeanne; Pons, Sandrine; Ghaleh, Bijan; Blondeau, Jean-Paul; Frank Lezoualc’h, And
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies
2019 Masci, D.; Hind, C.; Islam, M. K.; Toscani, A.; Clifford, M.; Coluccia, A.; Conforti, Irene; Touitou, M.; Memdouh, S.; Wei, X.; La Regina, G.; Silvestri, R.; Sutton, J. M.; Castagnolo, D.
Design, synthesis and biological evaluation of PDZ1 targeting NHERF1 inhibitors as anticancer agents
2019 La Regina, G.; Naccarato, V.; Masci, D.; Puxeddu, M.; Bufano, M.; Nalli, M.; Coluccia, A.; Orlando, V.; Canettieri, G.; Gianni, S.; Silvestri, R.
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents
2019 Coluccia, A.; La Regina, G.; Naccarato, V.; Nalli, M.; Orlando, V.; Biagioni, S.; De Angelis, M. L.; Baiocchi, M.; Gautier, C.; Gianni, S.; Di Pastena, F.; Di Magno, L.; Canettieri, G.; Coluccia, A. M. L.; Silvestri, R.
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin
2019 Cammisotto, Vittoria; Carnevale, Roberto; Nocella, Cristina; Stefanini, Lucia; Bartimoccia, Simona; Coluccia, Antonio; Silvestri, Romano; Pignatelli, Pasquale; Pastori, Daniele; Violi, Francesco
Inhibition of human Norovirus replication by a novel class of oindolylarylsulfones in vitro and in zebrafish larvae
2019 Van Dycke, Jana; Naccarato, Valentina; LA REGINA, Giuseppe; Mastrangelo, Eloise; Tarantino, Delia; Neyts, Johan; Silvestri, Romano; Rocha-Pereira, Joana
Nitrogen donor ligands and their coordination compounds as a tool for treatment of multi drug resistant tumors
2019 Filipović, Nr; Todorović, Tr; Bjelogrlić, S; Silvestri, R; La Regina, G; Pelliccia, S; Padron, Jm; Schembri-Wismayer, P; Donard, M; Gulea, M; Muler, Cd
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b
2019 Pippa, S; Mannironi, C; Licursi, V; Bombardi, Luca; Colotti, G; Cundari, E; Mollica, A; Coluccia, A; Naccarato, V; La Regina, G; Silvestri, R; Negri, R
Towards modern anticancer agents that interact with tubulin
2019 La Regina, G.; Coluccia, A.; Naccarato, V.; Silvestri, R.
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors
2018 La Regina, G.; Naccarato, V.; Coluccia, A.; Hamel, E.; Silvestri, R.
Indolylarylsulfones with potent anti-HIV-1 activity
2018 Masci, Domiziana; LA REGINA, Giuseppe; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano
Treating chronic myeloid leukemia by inhibition of tubulin polymerization
2018 LA REGINA, Giuseppe; Coluccia, Antonio; Naccarato, Valentina; Maria Luce Coluccia, Addolorata; Hamel, Ernest; Novellino, Ettore; Silvestri, Romano
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors
2018 La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Naccarato, Valentina; Famiglini, Valeria; Nalli, Marianna; Masci, Domiziana; Verrico, Annalisa; Rovella, Paola; Mazzoccoli, Carmela; Da Pozzo, Eleonora; Cavallini, Chiara; Martini, Claudia; Vultaggio, Stefania; Dondio, Giulio; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano
Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors
2018 Famiglini, V.; Silvestri, R.
Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects
2018 Carnevale, Roberto; Silvestri, Romano; Loffredo, Lorenzo; Novo, Marta; Cammisotto, Vittoria; Castellani, Valentina; Bartimoccia, Simona; Nocella, Cristina; Violi, Francesco
Bax activation blocks self-renewal and induces apoptosis of human glioblastoma stem cells
2018 Daniele, S.; Pietrobono, D.; Costa, B.; Giustiniano, M.; La Pietra, V.; Giacomelli, C.; LA REGINA, Giuseppe; Silvestri, Romano; Taliani, S.; Trincavelli, M. L.; Da Settimo, F.; Novellino, E.; Martini, C.; Marinelli, L.
Arginine- and lysine-rich peptides: synthesis, characterization and antimicrobial activity
2018 Mollica, A.; Macedonio, G.; Stefanucci, Azzurra; Costante, R.; Carradori, Simone; Cataldi, V.; DI GIULIO, ANNA MARIA; Cellini, L.; Silvestri, Romano; Giordano, C.; Scipioni, Anita; Punzi, P.; Mirzaie, S.
Indolylarylsulfones as novel potent anti-HIV-1 agents
2018 Masci, Domiziana; LA REGINA, Giuseppe; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano
A high-throughput screening of a chemical compound library in ovarian cancer stem cells
2018 Ricci, F.; Carrassa, L.; Christodoulou, M. S.; Passarella, D.; Michel, B.; Benhida, R.; Martinet, N.; Hunyadi, A.; Ioannou, E.; Roussis, V.; Musso, L.; Dallavalle, S.; Silvestri, R.; Westwood, N.; Mori, M.; Ingallina, C.; Botta, B.; Kavetsou, E.; Detsi, A.; Majer, Z.; Hudecz, F.; Bősze, S.; Kaminska, B.; Hansen, T. V.; Bertrand, P.; Athanassopulos, C. M.; Damia, G.
β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy
2018 Saponaro, Concetta; Sergio, Sara; Coluccia, Antonio; De Luca, Maria; LA REGINA, Giuseppe; Mologni, Luca; Famiglini, Valeria; Naccarato, Valentina; Bonetti, Daniela; Gautier, CANDICE NATACHA ANNA; Gianni, Stefano; Vergara, Daniele; Salzet, Michel; Fournier, Isabelle; Bucci, Cecilia; Silvestri, Romano; Gambacorti Passerini, Carlo; Maffia, Michele; Maria Luce Coluccia, Addolorata
Structure-based drug design of potent pyrazole derivatives against Rhinovirus replication
2018 Da Costa, L.; Scheers, E.; Coluccia, A.; Casulli, A.; Roche, M.; Di Giorgio, C.; Neyts, J.; Terme, T.; Cirilli, R.; La Regina, G.; Silvestri, R.; Mirabelli, C.; Vanelle, P.
A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist
2018 Riccio, G.; Bottone, S.; La Regina, G.; Badolati, N.; Passacantilli, S.; Rossi, G. B.; Accardo, A.; Dentice, M.; Silvestri, R.; Novellino, E.; Stornaiuolo, M.
Drug design and synthesis of new indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors
2017 Masci, Domiziana; LA REGINA, Giuseppe; Famiglini, Valeria; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano
Drug design and synthesis of new indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors
2017 Passacantilli, Sara; Famiglini, Valeria; LA REGINA, Giuseppe; Coluccia, Antonio; Masci, Domiziana; Esté, José A.; Maga, Giovanni; Silvestri, Romano
New inhibitors of Dengue and Zika virus protease
2017 Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Lee, Jin-Ching; Silvestri, Romano
Inhibition of Dengue virus by novel inhibitors of RNA-dependent RNA polymerase and protease activities
2017 LA REGINA, Giuseppe; Famiglini, Valeria; Masci, Domiziana; Coluccia, Antonio; Lee, Jin-Ching; Hiscott, John; Silvestri, Romano
New pyrrole inhibitors of chronic myeloid leukemia cell growth
2017 Naccarato, Valentina; LA REGINA, Giuseppe; Coluccia, Antonio; Maria Luce Coluccia, Addolorata; Hamel, Hernest; Silvestri, Romano
Computer-aided identification and lead optimization of dual murine double minute 2 and 4 binders: structure-activity relationship studies and pharmacological activity
2017 Giustiniano, M.; Daniele, S.; Pelliccia, S.; La Pietra, V.; Pietrobono, D.; Brancaccio, D.; Cosconati, S.; Messere, A.; Giuntini, S.; Cerofolini, L.; Fragai, M.; Luchinat, C.; Taliani, S.; La Regina, G.; Da Settimo, F.; Silvestri, R.; Martini, C.; Novellino, E.; Marinelli, L.
p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells
2017 Soriani, Alessandra; Borrelli, Cristiana; Ricci, Biancamaria; Molfetta, Rosa; Zingoni, Alessandra; Fionda, Cinzia; Carnevale, Silvia; Abruzzese, MARIA PIA; Petrucci, MARIA TERESA; Ricciardi, Maria Rosaria; LA REGINA, Giuseppe; Cesare, Erica Di; Lavia, Patrizia; Silvestri, Romano; Paolini, Rossella; Cippitelli, Marco; Santoni, Angela
Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors
2017 Mollica, Adriano; Pelliccia, Sveva; Famiglini, Valeria; Stefanucci, Azzurra; Macedonio, Giorgia; Chiavaroli, Annalisa; Orlando, Giustino; Brunetti, Luigi; Ferrante, Claudio; Pieretti, Stefano; Novellino, Ettore; Benyhe, Sandor; Zador, Ferenc; Erdei, Anna; Szucs, Edina; Samavati, Reza; Dvrorasko, Szalbolch; Tomboly, Csaba; Ragno, Rino; Patsilinakos, Alexandros; Silvestri, Romano
Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells
2017 Stirpe, Mariarita; Palermo, Vanessa; Bianchi, Michele Maria; Silvestri, Romano; Falcone, Claudio; Tenore, Giancarlo; Novellino, Ettore; Mazzoni, Cristina
Chiral indolylarylsulfone non-nucleoside reverse transcriptase inhibitors as new potent and broad spectrum anti-HIV-1 agents
2017 Famiglini, Valeria; LA REGINA, Giuseppe; Coluccia, Antonio; Masci, Domiziana; Brancale, Andrea; Badia, Roger; Riveira muã±oz, Eva; Estã©, Josã© A.; Crespan, Emmanuele; Brambilla, Alessandro; Maga, Giovanni; Catalano, Myriam; Limatola, Cristina; Formica, Francesca Romana; Cirilli, Roberto; Novellino, Ettore; Silvestri, Romano
N-Pyrrylarylsulfones with high therapeutic potential
2017 Famiglini, Valeria; Silvestri, Romano; Castellano, Sabrina
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules
2017 DI CESARE, Erica; Verrico, Annalisa; Miele, Andrea; Giubettini, Maria; Rovella, Paola; Coluccia, Antonio; Famiglini, Valeria; LA REGINA, Giuseppe; Cundari, Enrico; Silvestri, Romano; Lavia, Patrizia
Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: a combined computational and experimental study
2017 Da Costa, Laurene; Scheers, Els; Coluccia, Antonio; Rosetti, Alessia; Roche, Manon; Neyts, Johan; Terme, Thierry; Cirilli, Roberto; Mirabelli, Carmen; Silvestri, Romano; Vanelle, Patrice
3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin
2017 LA REGINA, Giuseppe; Naccarato, Valentina; Coluccia, Antonio; Maria Luce Coluccia, Addolorata; Hamel, Ernest; Silvestri, Romano
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities
2017 Pelliccia, S.; Wub, Y. H.; Coluccia, A.; La Regina, G.; Tseng, C. K.; Famiglini, V.; Masci, D.; Hiscott, J.; Lee, J. C.; Silvestri, R.
3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin
2017 LA REGINA, Giuseppe; Bai, R.; Coluccia, Antonio; Famiglini, Valeria; Passacantilli, Sara; Naccarato, Valentina; Ortar, Giorgio; Mazzoccoli, Carmela; Ruggieri, V.; Agriesti, F.; Piccoli, C.; Tataranni, T.; Nalli, Marianna; Brancale, A.; Vultaggio, S.; Mercurio, C.; Varasi, M.; Saponaro, C.; Sergio, S.; Maffia, M.; Coluccia, A. M. L.; Hamel, E.; Silvestri, Romano
New Inhibitors of Dengue Virus Replication
2016 Famiglini, Valeria; Pelliccia, Sveva; LA REGINA, Giuseppe; Coluccia, Antonio; Lee, J. C.; Silvestri, Romano
New Inhibitors of indoleamine 2,3-dioxygenase 1: molecular modelling studies, synthesis and biological evaluation
2016 LA REGINA, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; Passacantilli, Sara; Mazzoccoli, Carmela; Takikawa, O.; Silvestri, Romano
Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines
2016 Filipović, N. R.; Bjelogrlić, S.; Portalone, G.; Pelliccia, S.; Silvestri, R.; Klisurić, O.; Senćanski, M.; Stanković, D.; Todorović, T. R.; Muller, Christian D.
Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo
2016 Masuelli, Laura; Pantanella, Fabrizio; LA REGINA, Giuseppe; Benvenuto, Monica; Fantini, Massimo; Mattera, Rosanna; DI STEFANO, Enrica; Mattei, Maurizio; Silvestri, Romano; Schippa, Serena; Manzari, Vittorio; Modesti, Andrea; Bei, Roberto
VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection
2016 Da Costa, Laurène; Roche, Manon; Scheers, Els; Coluccia, Antonio; Neyts, Johan; Terme, Thierry; Leyssen, Pieter; Silvestri, Romano; Vanelle, Patrice
Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase
2016 Pinto, Andrea; Tamborini, Lucia; Pennacchietti, Eugenia; Coluccia, Antonio; Silvestri, Romano; Cullia, Gregorio; De Micheli, Carlo; Conti, Paola; DE BIASE, Daniela
Focus on chirality of HIV-1 non-nucleoside reverse transcriptase inhibitors
2016 Famiglini, Valeria; Silvestri, Romano
Structure-based virtual screening to get new scaffold inhibitors of the Ser/Thr protein kinase PknB from Mycobacterium tuberculosis
2016 Coluccia, Antonio; LA REGINA, Giuseppe; Barilone, Nathalie; Lisa, María Natalia; Brancale, Andrea; André Leroux, Gwenaëlle; Alzari, Pedro M.; Silvestri, Romano
New inhibitors of indoleamine 2,3-dioxygenase 1: molecular modeling studies, synthesis, and biological evaluation
2016 Coluccia, Antonio; Passacantilli, Sara; Famiglini, Valeria; Sabatino, Manuela; Patsilinakos, Alexandros; Ragno, Rino; Mazzoccoli, Carmela; Sisinni, L.; Okuno, A.; Takikawa, O.; Silvestri, Romano; LA REGINA, Giuseppe
Synthesis of New Indoles with Potent Tubulin Polymerization Inhibiting Activity Including Hedgehog-Dependent Cancer and Enhanced Stimulation of NK Cell Cytotoxic Activity
2015 Passacantilli, Sara; LA REGINA, Giuseppe; Coluccia, Antonio; Creta, Matteo; Hamel, Ernest; Novellino, Ettore; Silvestri, Romano
Drug Design and Synthesis of New Indolylarylsulfones as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
2015 Famiglini, Valeria; LA REGINA, Giuseppe; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano
New Pyrazolecarboxamides a s Anti-HCV Agents via Targeting Cyclooxygenase-2
2015 Pelliccia, Sveva; LA REGINA, Giuseppe; Manvar, Dinesh; Kaushik Basu, Neerja; Neyts, Johan; Silvestri, Romano
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents
2015 Stornaiuolo, M.; LA REGINA, Giuseppe; Passacantilli, Sara; Grassia, G.; Coluccia, Antonio; La Pietra, V.; Giustiniano, M.; Cassese, H.; Di Maro, S.; Brancaccio, D.; Taliani, S.; Ialenti, A.; Silvestri, Romano; Martini, C.; Novellino, E.; Marinelli, L.
New indole tubulin assembly inhibitors with stable arrest of mitotic progression, enhanced stimulation of natural killer cell cytotoxic activity and repression of Hedgehog-dependent cancer
2015 LA REGINA, Giuseppe; Coluccia, Antonio; Hamel, Ernest; Novellino, Ettore; Silvestri, Romano
Poster: "In vivo selection of JARID histone demethylases inhibitors and their use to enlighten the biological role of these enzymes in yeast and mammalian cells with focus on transcriptional regulation”
2015 Danovska, Svetlana; Cundari, Enrico; Mannironi, Cecilia; Licursi, Valerio; Rinaldi, Teresa; Fabozzi, Simone; Cerini, Valentina; Proietto, Marco; Pippa, Simone; Coluccia, Antonio; LA REGINA, Giuseppe; Silvestri, Romano; Negri, Rodolfo
Pharmacological folding chaperones act as allosteric ligands of Frizzled4
2015 Generoso, S. F; Giustiniano, M; LA REGINA, Giuseppe; Bottone, S; Passacantilli, Sara; Di Maro, S; Cassese, H; Bruno, A; Mallardo, M; Dentice, M; Silvestri, Romano; Marinelli, L; Sarnataro, D; Bonatti, S; Novellino, E; Stornaiuolo, M.
Discovery of 1,1'-biiphenyl-4-sulfonamides as a new class of potent and selective carbonic anhydrase XIV inhibitors
2015 LA REGINA, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Monti, Ludovica; Vullo, Daniela; Nuti, Elisa; Alterio, Vincenzo; De Simone, Giuseppina; Monti, Simona Maria; Pan, Peiwen; Parkkila, Seppo; Supuran, Claudiu T.; Rossello, Armando; Silvestri, Romano
Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells
2015 Philchenkov, Alex A.; Zavelevich, Michael P.; Tryndyak, Volodymyr P.; Kuiava, Ludmila M.; Blokhin, Dmitry Yu; Miura, Koh; Silvestri, Romano; Pogribny, Igor P.
New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2
2015 Manvar, D.; Pelliccia, S.; La Regina, G.; Famiglini, V.; Coluccia, A.; Ruggieri, A.; Anticoli, S.; Lee, J. -C.; Basu, A.; Cevik, O.; Nencioni, L.; Palamara, A. T.; Zamperini, C.; Botta, M.; Neyts, J.; Leyssen, P.; Kaushik-Basu, N.; Silvestri, R.
New frontiers in selective human MAO-B inhibitors
2015 Carradori, S; Silvestri, R.
Kinetic characterization of 4,4'-biphenylsulfonamides as selective non-zinc binding MMP inhibitors
2015 Santamaria, S; Nuti, E; Cercignani, G; LA REGINA, Giuseppe; Silvestri, Romano; Supuran C., T; Rossello, A.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent | 2023 | Nalli, Marianna; Di Magno, Laura; Wen, Yichao; Liu, Xin; D’Ambrosio, Michele; Puxeddu, Michela; Parisi, Anastasia; Sebastiani, Jessica; Sorato, Andrea; Coluccia, Antonio; Ripa, Silvia; Di Pastena, Fiorella; Capelli, Davide; Montanari, Roberta; Masci, Domiziana; Urbani, Andrea; Naro, Chiara; Sette, Claudio; Orlando, Viviana; D’Angelo, Sara; Biagioni, Stefano; Bigogno, Chiara; Dondio, Giulio; Pastore, Arianna; Stornaiuolo, Mariano; Canettieri, Gianluca; Liu, Te; Silvestri, Romano; La Regina, Giuseppe | |
| 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells | 2023 | Masci, Domiziana; Puxeddu, Michela; Di Magno, Laura; D'Ambrosio, Michele; Parisi, Anastasia; Nalli, Marianna; Bai, Ruoli; Coluccia, Antonio; Sciò, Pietro; Orlando, Viviana; D'Angelo, Sara; Biagioni, Stefano; Urbani, Andrea; Hamel, Ernest; Nocentini, Alessio; Filiberti, Serena; Turati, Marta; Ronca, Roberto; Kopecka, Joanna; Riganti, Chiara; Fionda, Cinzia; Bordone, Rosa; Della Rocca, Giorgia; Canettieri, Gianluca; Supuran, Claudiu T; Silvestri, Romano; La Regina, Giuseppe | |
| RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo | 2023 | Sebastiani, J.; Puxeddu, M.; Nalli, M.; Bai, R.; Altieri, L.; Rovella, P.; Gaudio, E.; Trisciuoglio, D.; Spriano, F.; Lavia, P.; Fionda, C.; Masci, D.; Urbani, A.; Bigogno, C.; Dondio, G.; Hamel, E.; Bertoni, F.; Silvestri, R.; La Regina, G. | |
| Recent advances in drug discovery for Triple-Negative Breast cancer treatment | 2023 | Masci, Domiziana; Naro, Chiara; Puxeddu, Michela; Urbani, Andrea; Sette, Claudio; La Regina, Giuseppe; Silvestri, Romano | |
| Toll-like receptor 4-dependent platelet-related thrombosis in SARS-CoV-2 infection | 2023 | Carnevale, Roberto; Cammisotto, Vittoria; Bartimoccia, Simona; Nocella, Cristina; Castellani, Valentina; Bufano, Marianna; Loffredo, Lorenzo; Sciarretta, Sebastiano; Frati, Giacomo; Coluccia, Antonio; Silvestri, Romano; Ceccarelli, Giancarlo; Oliva, Alessandra; Venditti, Mario; Pugliese, Francesco; Maria Mastroianni, Claudio; Turriziani, Ombretta; Leopizzi, Martina; D'Amati, Giulia; Pignatelli, Pasquale; Violi, Francesco | |
| Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands | 2023 | Dvorácskó, Szabolcs; Dimmito, Marilisa Pia; Sebastiani, Jessica; La Regina, Giuseppe; Silvestri, Romano; Pieretti, Stefano; Stefanucci, Azzurra; Tömböly, Csaba; Mollica, Adriano | |
| A Novel Validated UHPLC Method for the Estimation of Rosuvastatin and Its Complete Impurity Profile in Tablet Formulations | 2023 | Mammone, F. R.; Zanitti, L.; Puxeddu, M.; La Regina, G.; Silvestri, R.; Borioni, A.; Cirilli, R. | |
| Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators | 2023 | Bufano, Marianna; Puxeddu, Michela; Nalli, Marianna; La Regina, Giuseppe; Toto, Angelo; Liberati, Francesca Romana; Paone, Alessio; Cutruzzolà, Francesca; Masci, Domiziana; Bigogno, Chiara; Dondio, Giulio; Silvestri, Romano; Gianni, Stefano; Coluccia, Antonio | |
| EFFICACY AND SAFETY OF A NOVEL FOOD SUPPLEMENT IN THE TREATMENT OF FUNCTIONAL DYSPEPSIA: A PILOT OPEN STUDY | 2022 | Innocenti, Matteo; Silvestri, Romano; Ceracchi, Maurizio; Silvestrini, Bruno | |
| Novel quinoline derivatives and uses thereof | 2022 | Minucci, Saverio; De Wulf Peter Arthur, Irene; Romanenghi, Mauro; Cazzoli, Riccardo; Damizia, Michela; Silvestri, Romano; La Regina, Giuseppe; Coluccia, Antonio | |
| Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor | 2022 | Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe La; Puxeddu, Michela; Toto, Angelo; Paone, Alessio; Bouzidi, Amani; Musto, Giorgia; Badolati, Nadia; Orlando, Viviana; Biagioni, Stefano; Masci, Domiziana; Cantatore, Chiara; Cirilli, Roberto; Cutruzzolà, Francesca; Gianni, Stefano; Stornaiuolo, Mariano; Silvestri, Romano | |
| Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment | 2022 | Di Magno, L; Coluccia, A; Bufano, M; Ripa, S; La Regina, G; Nalli, M; Di Pastena, F; Canettieri, G; Silvestri, R; Frati, L | |
| Emerging Direct Targeting β-Catenin Agents | 2022 | Nalli, M.; Masci, D.; Urbani, A.; La Regina, G.; Silvestri, R. | |
| Single-run chemo- and enantio-selective high-performance liquid chromatography separation of tramadol and its principal metabolite, O-desmethyltramadol, using a chlorinated immobilized amylose-based chiral stationary phase under multimodal elution conditions | 2022 | Cantatore, C.; La Regina, G.; Ferretti, R.; Silvestri, R.; Cirilli, R. | |
| Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor | 2022 | Puxeddu, Michela; Wu, Jianchao; Bai, Ruoli; D’Ambrosio, Michele; Nalli, Marianna; Coluccia, Antonio; Manetto, Simone; Ciogli, Alessia; Masci, Domiziana; Urbani, Andrea; Fionda, Cinzia; Coni, Sonia; Bordone, Rosa; Canettieri, Gianluca; Bigogno, Chiara; Dondio, Giulio; Hamel, Ernest; Liu, Te; Silvestri, Romano; LA REGINA, Giuseppe | |
| Modulating undruggable targets to overcome cancer therapy resistance | 2022 | Passirani, C.; Vessieres, A.; La Regina, G.; Link, W.; Silvestri, R. | |
| Exploring CCRL2 chemerin binding using accelerated molecular dynamics | 2022 | Bufano, M.; Laffranchi, M.; Sozzani, S.; Raimondo, D.; Silvestri, R.; Coluccia, A. | |
| A METHOD TO MEASURE THE BARRIER EFFECT OF DRUGS AND ITS APPLICATION IN THE STUDY OF HYDROLYZED COLLAGEN | 2021 | Silvestrini, Bruno; Silvestri, Romano; Cheng, C. Y.; Ceracchi, Maurizio; Innocenti, Matteo | |
| Novel quinoline derivatives and uses thereof | 2021 | Silvestri, Romano; La Regina, Giuseppe; Coluccia, Antonio; Minucci, Saverio; De Wulf, Peter Arthur Irene | |
| Emerging therapeutic agents for colorectal cancer | 2021 | Nalli, M.; Puxeddu, M.; La Regina, G.; Gianni, S.; Silvestri, R. | |
| Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia | 2021 | Puxeddu, M.; Shen, H.; Bai, R.; Coluccia, A.; Bufano, M.; Nalli, M.; Sebastiani, J.; Brancaccio, D.; Da Pozzo, E.; Tremolanti, C.; Martini, C.; Orlando, V.; Biagioni, S.; Sinicropi, M. S.; Ceramella, J.; Iacopetta, D.; Coluccia, A. M. L.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G. | |
| CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme | 2021 | Daniele, S.; La Pietra, V.; Piccarducci, R.; Pietrobono, D.; Cavallini, C.; D'Amore, V. M.; Cerofolini, L.; Giuntini, S.; Russomanno, P.; Puxeddu, M.; Nalli, M.; Pedrini, M.; Fragai, M.; Luchinat, C.; Novellino, E.; Taliani, S.; La Regina, G.; Silvestri, R.; Martini, C.; Marinelli, L. | |
| Discovery of a novel class of norovirus inhibitors with high barrier of resistance | 2021 | Van Dycke, J.; Puxeddu, M.; La Regina, G.; Mastrangelo, E.; Tarantino, D.; Rymenants, J.; Sebastiani, J.; Nalli, M.; Matthijnssens, J.; Neyts, J.; Silvestri, R.; Rocha-Pereira, J. | |
| Enantiomerization barrier of 1-[2-(2-methyl-2-methoxycarbonylacetamido) benzenesulfonyl]-1h-pyrrole studied by enantioselective dynamic HPLC, classical off column technique and computational approach | 2021 | Buonsenso, Fabio; Cirilli, Roberto; Silvestri, Romano; Pierini, Marco | |
| Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer | 2021 | Nardella, Caterina; Visconti, Lorenzo; Malagrinò, Francesca; Pagano, Livia; Bufano, Marianna; Nalli, Marianna; Coluccia, Antonio; La Regina, Giuseppe; Silvestri, Romano; Gianni, Stefano; Toto, Angelo | |
| RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota | 2021 | Liu, T.; Wu, J.; Han, C.; Gong, Z.; La Regina, G.; Chen, J.; Dou, F.; Silvestri, R.; Chen, C.; Yu, Z. | |
| RS4651 suppresses lung fibroblast activation via the TGF-β1/SMAD signalling pathway | 2021 | Li, S.; Xu, A.; Li, Y.; Tan, C.; La Regina, G.; Silvestri, R.; Wang, H.; Qi, W. | |
| Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage | 2020 | Coluccia, A.; Puxeddu, M.; Nalli, M.; Wei, C. K.; Wu, Y. H.; Mastrangelo, E.; Elamin, T.; Tarantino, D.; Bugert, J. J.; Schreiner, B.; Nolte, J.; Schwarze, F.; La Regina, G.; Lee, J. C.; Silvestri, R. | |
| Sulfonamide inhibitors of beta-catenin signaling as anticancer agents with different output on c-Myc | 2020 | DI MAGNO, Laura; DI PASTENA, Fiorella; Puxeddu, Michela; LA REGINA, Giuseppe; Coluccia, Antonio; Ciogli, Alessia; Manetto, Simone; Maroder, Marella; Canettieri, Gianluca; Silvestri, Romano; Nalli, Marianna | |
| Discovery of new 1,1'-biphenyl-4-sulfonamides as selective subnanomolar human carbonic anhydrase II inhibitors | 2020 | La Regina, G.; Puxeddu, M.; Nalli, M.; Vullo, D.; Gratteri, P.; Supuran, C. T.; Nocentini, A.; Silvestri, R. | |
| New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains | 2020 | Nalli, M.; Armijos Rivera, J. I.; Masci, D.; Coluccia, A.; Badia, R.; Riveira-Muñoz, E.; Brambilla, A.; Cinquina, E.; Turriziani, O.; Falasca, F.; Catalano, M.; Limatola, C.; Esté, J. A.; Maga, G.; Silvestri, R.; Crespan, E.; La Regina, G. | |
| HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53 | 2020 | Capdevielle, Caroline; Desplat, Angelique; Charpentier, Justine; Sagliocco, Francis; Thiebaud, Pierre; Theze, Nadine; Fedou, Sandrine; Hooks, Katarzyna B.; Silvestri, Romano; Guyonnet-Duperat, Veronique; Petrel, Melina; Raymond, Anne-Aurelie; Dupuy, Jean-William; Grosset, Christophe F.; Hagedorn, Martin | |
| Selenotriapine - an isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors | 2020 | Filipović, N. R.; Bjelogrlić, S. K.; Pelliccia, S.; Jovanović, V. B.; Kojić, M.; Senćanski, M.; La Regina, G.; Silvestri, R.; Muller, C. D.; Todorović, T. R. | |
| Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites | 2020 | Scala, R.; Di Matteo, A.; Coluccia, A.; Lo Sciuto, A.; Federici, L.; Travaglini-Allocatelli, C.; Visca, P.; Silvestri, R.; Imperi, F. | |
| Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies | 2020 | Puxeddu, M.; Shen, H.; Bai, R.; Coluccia, A.; Nalli, M.; Mazzoccoli, C.; Da Pozzo, E.; Cavallini, C.; Martini, C.; Orlando, V.; Biagioni, S.; Mazzoni, C.; Coluccia, A. M. L.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G. | |
| Targeting the interaction between the SH3 domain of Grb2 and Gab2 | 2020 | Malagrinò, Francesca; Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe; Puxeddu, Michela; Toto, Angelo; Visconti, Lorenzo; Paone, Alessio; Magnifico, Maria Chiara; Troilo, Francesca; Cutruzzolà, Francesca; Silvestri, Romano; Gianni, Stefano | |
| Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics | 2020 | Bufano, M.; Laudette, M.; Blondeau, J. -P.; Lezoualc'H, F.; Nalli, M.; Silvestri, R.; Brancale, A.; Coluccia, A. | |
| Design, synthesis and discovery of novel N,N'-carbazoyl-aryl-urea inhibitors of Zika NS5 methyltransferase and virus replication. | 2020 | Spizzichino, S; Mattedi, G; Lauder, K; Valle, C; Aouadi, W; Canard, B; Decroly, E; Kaptein, Sjf; Neyts, J; Graham, C; Sule, Z; Barlow, Dj; Silvestri, R; Castagnolo, D. | |
| First in class pdz1 targeting NHERF1 inhibitors as anticancer agents | 2019 | LA REGINA, Giuseppe; Naccarato, Valentina; Puxeddu, Michela; Bufano, Marianna; Nalli, Marianna; Coluccia, Antonio; Silvestri, Romano | |
| Small molecule inhibitors of kdm5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B | 2019 | La Regina, G.; Naccarato, V.; Masci, D.; Puxeddu, M.; Nalli, M.; Coluccia, A.; Negri, R.; Silvestri, R. | |
| New anti-cancer agents through an interaction with tubulin | 2019 | La Regina, G; Coluccia, A; Naccarato, V; Silvestri, R. | |
| Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress | 2019 | Laudette, Marion; Coluccia, Antonio; Sainte-Marie, Yannis; Solari, Andrea; Fazal, Loubina; Sicard, Pierre; Silvestri, Romano; Mialet-Perez, Jeanne; Pons, Sandrine; Ghaleh, Bijan; Blondeau, Jean-Paul; Frank Lezoualc’h, And | |
| Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies | 2019 | Masci, D.; Hind, C.; Islam, M. K.; Toscani, A.; Clifford, M.; Coluccia, A.; Conforti, Irene; Touitou, M.; Memdouh, S.; Wei, X.; La Regina, G.; Silvestri, R.; Sutton, J. M.; Castagnolo, D. | |
| Design, synthesis and biological evaluation of PDZ1 targeting NHERF1 inhibitors as anticancer agents | 2019 | La Regina, G.; Naccarato, V.; Masci, D.; Puxeddu, M.; Bufano, M.; Nalli, M.; Coluccia, A.; Orlando, V.; Canettieri, G.; Gianni, S.; Silvestri, R. | |
| Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents | 2019 | Coluccia, A.; La Regina, G.; Naccarato, V.; Nalli, M.; Orlando, V.; Biagioni, S.; De Angelis, M. L.; Baiocchi, M.; Gautier, C.; Gianni, S.; Di Pastena, F.; Di Magno, L.; Canettieri, G.; Coluccia, A. M. L.; Silvestri, R. | |
| Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin | 2019 | Cammisotto, Vittoria; Carnevale, Roberto; Nocella, Cristina; Stefanini, Lucia; Bartimoccia, Simona; Coluccia, Antonio; Silvestri, Romano; Pignatelli, Pasquale; Pastori, Daniele; Violi, Francesco | |
| Inhibition of human Norovirus replication by a novel class of oindolylarylsulfones in vitro and in zebrafish larvae | 2019 | Van Dycke, Jana; Naccarato, Valentina; LA REGINA, Giuseppe; Mastrangelo, Eloise; Tarantino, Delia; Neyts, Johan; Silvestri, Romano; Rocha-Pereira, Joana | |
| Nitrogen donor ligands and their coordination compounds as a tool for treatment of multi drug resistant tumors | 2019 | Filipović, Nr; Todorović, Tr; Bjelogrlić, S; Silvestri, R; La Regina, G; Pelliccia, S; Padron, Jm; Schembri-Wismayer, P; Donard, M; Gulea, M; Muler, Cd | |
| Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b | 2019 | Pippa, S; Mannironi, C; Licursi, V; Bombardi, Luca; Colotti, G; Cundari, E; Mollica, A; Coluccia, A; Naccarato, V; La Regina, G; Silvestri, R; Negri, R | |
| Towards modern anticancer agents that interact with tubulin | 2019 | La Regina, G.; Coluccia, A.; Naccarato, V.; Silvestri, R. | |
| New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors | 2018 | La Regina, G.; Naccarato, V.; Coluccia, A.; Hamel, E.; Silvestri, R. | |
| Indolylarylsulfones with potent anti-HIV-1 activity | 2018 | Masci, Domiziana; LA REGINA, Giuseppe; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano | |
| Treating chronic myeloid leukemia by inhibition of tubulin polymerization | 2018 | LA REGINA, Giuseppe; Coluccia, Antonio; Naccarato, Valentina; Maria Luce Coluccia, Addolorata; Hamel, Ernest; Novellino, Ettore; Silvestri, Romano | |
| New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors | 2018 | La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Naccarato, Valentina; Famiglini, Valeria; Nalli, Marianna; Masci, Domiziana; Verrico, Annalisa; Rovella, Paola; Mazzoccoli, Carmela; Da Pozzo, Eleonora; Cavallini, Chiara; Martini, Claudia; Vultaggio, Stefania; Dondio, Giulio; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano | |
| Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors | 2018 | Famiglini, V.; Silvestri, R. | |
| Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects | 2018 | Carnevale, Roberto; Silvestri, Romano; Loffredo, Lorenzo; Novo, Marta; Cammisotto, Vittoria; Castellani, Valentina; Bartimoccia, Simona; Nocella, Cristina; Violi, Francesco | |
| Bax activation blocks self-renewal and induces apoptosis of human glioblastoma stem cells | 2018 | Daniele, S.; Pietrobono, D.; Costa, B.; Giustiniano, M.; La Pietra, V.; Giacomelli, C.; LA REGINA, Giuseppe; Silvestri, Romano; Taliani, S.; Trincavelli, M. L.; Da Settimo, F.; Novellino, E.; Martini, C.; Marinelli, L. | |
| Arginine- and lysine-rich peptides: synthesis, characterization and antimicrobial activity | 2018 | Mollica, A.; Macedonio, G.; Stefanucci, Azzurra; Costante, R.; Carradori, Simone; Cataldi, V.; DI GIULIO, ANNA MARIA; Cellini, L.; Silvestri, Romano; Giordano, C.; Scipioni, Anita; Punzi, P.; Mirzaie, S. | |
| Indolylarylsulfones as novel potent anti-HIV-1 agents | 2018 | Masci, Domiziana; LA REGINA, Giuseppe; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano | |
| A high-throughput screening of a chemical compound library in ovarian cancer stem cells | 2018 | Ricci, F.; Carrassa, L.; Christodoulou, M. S.; Passarella, D.; Michel, B.; Benhida, R.; Martinet, N.; Hunyadi, A.; Ioannou, E.; Roussis, V.; Musso, L.; Dallavalle, S.; Silvestri, R.; Westwood, N.; Mori, M.; Ingallina, C.; Botta, B.; Kavetsou, E.; Detsi, A.; Majer, Z.; Hudecz, F.; Bősze, S.; Kaminska, B.; Hansen, T. V.; Bertrand, P.; Athanassopulos, C. M.; Damia, G. | |
| β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy | 2018 | Saponaro, Concetta; Sergio, Sara; Coluccia, Antonio; De Luca, Maria; LA REGINA, Giuseppe; Mologni, Luca; Famiglini, Valeria; Naccarato, Valentina; Bonetti, Daniela; Gautier, CANDICE NATACHA ANNA; Gianni, Stefano; Vergara, Daniele; Salzet, Michel; Fournier, Isabelle; Bucci, Cecilia; Silvestri, Romano; Gambacorti Passerini, Carlo; Maffia, Michele; Maria Luce Coluccia, Addolorata | |
| Structure-based drug design of potent pyrazole derivatives against Rhinovirus replication | 2018 | Da Costa, L.; Scheers, E.; Coluccia, A.; Casulli, A.; Roche, M.; Di Giorgio, C.; Neyts, J.; Terme, T.; Cirilli, R.; La Regina, G.; Silvestri, R.; Mirabelli, C.; Vanelle, P. | |
| A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist | 2018 | Riccio, G.; Bottone, S.; La Regina, G.; Badolati, N.; Passacantilli, S.; Rossi, G. B.; Accardo, A.; Dentice, M.; Silvestri, R.; Novellino, E.; Stornaiuolo, M. | |
| Drug design and synthesis of new indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors | 2017 | Masci, Domiziana; LA REGINA, Giuseppe; Famiglini, Valeria; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano | |
| Drug design and synthesis of new indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors | 2017 | Passacantilli, Sara; Famiglini, Valeria; LA REGINA, Giuseppe; Coluccia, Antonio; Masci, Domiziana; Esté, José A.; Maga, Giovanni; Silvestri, Romano | |
| New inhibitors of Dengue and Zika virus protease | 2017 | Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Lee, Jin-Ching; Silvestri, Romano | |
| Inhibition of Dengue virus by novel inhibitors of RNA-dependent RNA polymerase and protease activities | 2017 | LA REGINA, Giuseppe; Famiglini, Valeria; Masci, Domiziana; Coluccia, Antonio; Lee, Jin-Ching; Hiscott, John; Silvestri, Romano | |
| New pyrrole inhibitors of chronic myeloid leukemia cell growth | 2017 | Naccarato, Valentina; LA REGINA, Giuseppe; Coluccia, Antonio; Maria Luce Coluccia, Addolorata; Hamel, Hernest; Silvestri, Romano | |
| Computer-aided identification and lead optimization of dual murine double minute 2 and 4 binders: structure-activity relationship studies and pharmacological activity | 2017 | Giustiniano, M.; Daniele, S.; Pelliccia, S.; La Pietra, V.; Pietrobono, D.; Brancaccio, D.; Cosconati, S.; Messere, A.; Giuntini, S.; Cerofolini, L.; Fragai, M.; Luchinat, C.; Taliani, S.; La Regina, G.; Da Settimo, F.; Silvestri, R.; Martini, C.; Novellino, E.; Marinelli, L. | |
| p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells | 2017 | Soriani, Alessandra; Borrelli, Cristiana; Ricci, Biancamaria; Molfetta, Rosa; Zingoni, Alessandra; Fionda, Cinzia; Carnevale, Silvia; Abruzzese, MARIA PIA; Petrucci, MARIA TERESA; Ricciardi, Maria Rosaria; LA REGINA, Giuseppe; Cesare, Erica Di; Lavia, Patrizia; Silvestri, Romano; Paolini, Rossella; Cippitelli, Marco; Santoni, Angela | |
| Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors | 2017 | Mollica, Adriano; Pelliccia, Sveva; Famiglini, Valeria; Stefanucci, Azzurra; Macedonio, Giorgia; Chiavaroli, Annalisa; Orlando, Giustino; Brunetti, Luigi; Ferrante, Claudio; Pieretti, Stefano; Novellino, Ettore; Benyhe, Sandor; Zador, Ferenc; Erdei, Anna; Szucs, Edina; Samavati, Reza; Dvrorasko, Szalbolch; Tomboly, Csaba; Ragno, Rino; Patsilinakos, Alexandros; Silvestri, Romano | |
| Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells | 2017 | Stirpe, Mariarita; Palermo, Vanessa; Bianchi, Michele Maria; Silvestri, Romano; Falcone, Claudio; Tenore, Giancarlo; Novellino, Ettore; Mazzoni, Cristina | |
| Chiral indolylarylsulfone non-nucleoside reverse transcriptase inhibitors as new potent and broad spectrum anti-HIV-1 agents | 2017 | Famiglini, Valeria; LA REGINA, Giuseppe; Coluccia, Antonio; Masci, Domiziana; Brancale, Andrea; Badia, Roger; Riveira muã±oz, Eva; Estã©, Josã© A.; Crespan, Emmanuele; Brambilla, Alessandro; Maga, Giovanni; Catalano, Myriam; Limatola, Cristina; Formica, Francesca Romana; Cirilli, Roberto; Novellino, Ettore; Silvestri, Romano | |
| N-Pyrrylarylsulfones with high therapeutic potential | 2017 | Famiglini, Valeria; Silvestri, Romano; Castellano, Sabrina | |
| Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules | 2017 | DI CESARE, Erica; Verrico, Annalisa; Miele, Andrea; Giubettini, Maria; Rovella, Paola; Coluccia, Antonio; Famiglini, Valeria; LA REGINA, Giuseppe; Cundari, Enrico; Silvestri, Romano; Lavia, Patrizia | |
| Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: a combined computational and experimental study | 2017 | Da Costa, Laurene; Scheers, Els; Coluccia, Antonio; Rosetti, Alessia; Roche, Manon; Neyts, Johan; Terme, Thierry; Cirilli, Roberto; Mirabelli, Carmen; Silvestri, Romano; Vanelle, Patrice | |
| 3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin | 2017 | LA REGINA, Giuseppe; Naccarato, Valentina; Coluccia, Antonio; Maria Luce Coluccia, Addolorata; Hamel, Ernest; Silvestri, Romano | |
| Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities | 2017 | Pelliccia, S.; Wub, Y. H.; Coluccia, A.; La Regina, G.; Tseng, C. K.; Famiglini, V.; Masci, D.; Hiscott, J.; Lee, J. C.; Silvestri, R. | |
| 3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin | 2017 | LA REGINA, Giuseppe; Bai, R.; Coluccia, Antonio; Famiglini, Valeria; Passacantilli, Sara; Naccarato, Valentina; Ortar, Giorgio; Mazzoccoli, Carmela; Ruggieri, V.; Agriesti, F.; Piccoli, C.; Tataranni, T.; Nalli, Marianna; Brancale, A.; Vultaggio, S.; Mercurio, C.; Varasi, M.; Saponaro, C.; Sergio, S.; Maffia, M.; Coluccia, A. M. L.; Hamel, E.; Silvestri, Romano | |
| New Inhibitors of Dengue Virus Replication | 2016 | Famiglini, Valeria; Pelliccia, Sveva; LA REGINA, Giuseppe; Coluccia, Antonio; Lee, J. C.; Silvestri, Romano | |
| New Inhibitors of indoleamine 2,3-dioxygenase 1: molecular modelling studies, synthesis and biological evaluation | 2016 | LA REGINA, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; Passacantilli, Sara; Mazzoccoli, Carmela; Takikawa, O.; Silvestri, Romano | |
| Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines | 2016 | Filipović, N. R.; Bjelogrlić, S.; Portalone, G.; Pelliccia, S.; Silvestri, R.; Klisurić, O.; Senćanski, M.; Stanković, D.; Todorović, T. R.; Muller, Christian D. | |
| Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo | 2016 | Masuelli, Laura; Pantanella, Fabrizio; LA REGINA, Giuseppe; Benvenuto, Monica; Fantini, Massimo; Mattera, Rosanna; DI STEFANO, Enrica; Mattei, Maurizio; Silvestri, Romano; Schippa, Serena; Manzari, Vittorio; Modesti, Andrea; Bei, Roberto | |
| VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection | 2016 | Da Costa, Laurène; Roche, Manon; Scheers, Els; Coluccia, Antonio; Neyts, Johan; Terme, Thierry; Leyssen, Pieter; Silvestri, Romano; Vanelle, Patrice | |
| Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase | 2016 | Pinto, Andrea; Tamborini, Lucia; Pennacchietti, Eugenia; Coluccia, Antonio; Silvestri, Romano; Cullia, Gregorio; De Micheli, Carlo; Conti, Paola; DE BIASE, Daniela | |
| Focus on chirality of HIV-1 non-nucleoside reverse transcriptase inhibitors | 2016 | Famiglini, Valeria; Silvestri, Romano | |
| Structure-based virtual screening to get new scaffold inhibitors of the Ser/Thr protein kinase PknB from Mycobacterium tuberculosis | 2016 | Coluccia, Antonio; LA REGINA, Giuseppe; Barilone, Nathalie; Lisa, María Natalia; Brancale, Andrea; André Leroux, Gwenaëlle; Alzari, Pedro M.; Silvestri, Romano | |
| New inhibitors of indoleamine 2,3-dioxygenase 1: molecular modeling studies, synthesis, and biological evaluation | 2016 | Coluccia, Antonio; Passacantilli, Sara; Famiglini, Valeria; Sabatino, Manuela; Patsilinakos, Alexandros; Ragno, Rino; Mazzoccoli, Carmela; Sisinni, L.; Okuno, A.; Takikawa, O.; Silvestri, Romano; LA REGINA, Giuseppe | |
| Synthesis of New Indoles with Potent Tubulin Polymerization Inhibiting Activity Including Hedgehog-Dependent Cancer and Enhanced Stimulation of NK Cell Cytotoxic Activity | 2015 | Passacantilli, Sara; LA REGINA, Giuseppe; Coluccia, Antonio; Creta, Matteo; Hamel, Ernest; Novellino, Ettore; Silvestri, Romano | |
| Drug Design and Synthesis of New Indolylarylsulfones as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors | 2015 | Famiglini, Valeria; LA REGINA, Giuseppe; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano | |
| New Pyrazolecarboxamides a s Anti-HCV Agents via Targeting Cyclooxygenase-2 | 2015 | Pelliccia, Sveva; LA REGINA, Giuseppe; Manvar, Dinesh; Kaushik Basu, Neerja; Neyts, Johan; Silvestri, Romano | |
| Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents | 2015 | Stornaiuolo, M.; LA REGINA, Giuseppe; Passacantilli, Sara; Grassia, G.; Coluccia, Antonio; La Pietra, V.; Giustiniano, M.; Cassese, H.; Di Maro, S.; Brancaccio, D.; Taliani, S.; Ialenti, A.; Silvestri, Romano; Martini, C.; Novellino, E.; Marinelli, L. | |
| New indole tubulin assembly inhibitors with stable arrest of mitotic progression, enhanced stimulation of natural killer cell cytotoxic activity and repression of Hedgehog-dependent cancer | 2015 | LA REGINA, Giuseppe; Coluccia, Antonio; Hamel, Ernest; Novellino, Ettore; Silvestri, Romano | |
| Poster: "In vivo selection of JARID histone demethylases inhibitors and their use to enlighten the biological role of these enzymes in yeast and mammalian cells with focus on transcriptional regulation” | 2015 | Danovska, Svetlana; Cundari, Enrico; Mannironi, Cecilia; Licursi, Valerio; Rinaldi, Teresa; Fabozzi, Simone; Cerini, Valentina; Proietto, Marco; Pippa, Simone; Coluccia, Antonio; LA REGINA, Giuseppe; Silvestri, Romano; Negri, Rodolfo | |
| Pharmacological folding chaperones act as allosteric ligands of Frizzled4 | 2015 | Generoso, S. F; Giustiniano, M; LA REGINA, Giuseppe; Bottone, S; Passacantilli, Sara; Di Maro, S; Cassese, H; Bruno, A; Mallardo, M; Dentice, M; Silvestri, Romano; Marinelli, L; Sarnataro, D; Bonatti, S; Novellino, E; Stornaiuolo, M. | |
| Discovery of 1,1'-biiphenyl-4-sulfonamides as a new class of potent and selective carbonic anhydrase XIV inhibitors | 2015 | LA REGINA, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Monti, Ludovica; Vullo, Daniela; Nuti, Elisa; Alterio, Vincenzo; De Simone, Giuseppina; Monti, Simona Maria; Pan, Peiwen; Parkkila, Seppo; Supuran, Claudiu T.; Rossello, Armando; Silvestri, Romano | |
| Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells | 2015 | Philchenkov, Alex A.; Zavelevich, Michael P.; Tryndyak, Volodymyr P.; Kuiava, Ludmila M.; Blokhin, Dmitry Yu; Miura, Koh; Silvestri, Romano; Pogribny, Igor P. | |
| New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2 | 2015 | Manvar, D.; Pelliccia, S.; La Regina, G.; Famiglini, V.; Coluccia, A.; Ruggieri, A.; Anticoli, S.; Lee, J. -C.; Basu, A.; Cevik, O.; Nencioni, L.; Palamara, A. T.; Zamperini, C.; Botta, M.; Neyts, J.; Leyssen, P.; Kaushik-Basu, N.; Silvestri, R. | |
| New frontiers in selective human MAO-B inhibitors | 2015 | Carradori, S; Silvestri, R. | |
| Kinetic characterization of 4,4'-biphenylsulfonamides as selective non-zinc binding MMP inhibitors | 2015 | Santamaria, S; Nuti, E; Cercignani, G; LA REGINA, Giuseppe; Silvestri, Romano; Supuran C., T; Rossello, A. |
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