Sfoglia per Autore MAI, Antonello
Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype
2024 Trionfetti, Flavia; Montaldo, Claudia; Caiello, Ivan; Bontempi, Giulio; Terri, Michela; Tiberi, Marta; Marchant, Vanessa; Domenici, Alessandro; Menè, Paolo; Cordani, Marco; Zwergel, Clemens; Prencipe, Giusi; Ruiz-Ortega, Marta; Valente, Sergio; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy
2024 Villares, Marie; Lourenço, Nelly; Ktorza, Ivan; Berthelet, Jérémy; Panagiotou, Aristeidis; Richard, Aurélie; Amo, Angélique; Koziy, Yulianna; Medjkane, Souhila; Valente, Sergio; Fioravanti, Rossella; Pioche-Durieu, Catherine; Lignière, Laurent; Chevreux, Guillaume; Mai, Antonello; Weitzman, Jonathan B.
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling
2024 Terri, Michela; Sandoval, Pilar; Bontempi, Giulio; Montaldo, Claudia; Tomero-Sanz, Henar; de Turris, Valeria; Trionfetti, Flavia; Pascual-Antón, Lucía; Clares-Pedrero, Irene; Battistelli, Cecilia; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Rosanò, Laura; Del Pozo, Miguel Ángel; Sánchez-Álvarez, Miguel; Cabañas, Carlos; Tripodi, Marco; López-Cabrera, Manuel; Strippoli, Raffaele
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process
2024 Lambona, Chiara; Zwergel, Clemens; Valente, Sergio; Mai, Antonello
Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
2024 Pecci, Valeria; Troisi, Fabiola; Aiello, Aurora; De Martino, Sara; Carlino, Angela; Fiorentino, Vincenzo; Ripoli, Cristian; Rotili, Dante; Pierconti, Francesco; Martini, Maurizio; Porru, Manuela; Pinto, Francesco; Mai, Antonello; Bassi, Pier Francesco; Grassi, Claudio; Gaetano, Carlo; Pontecorvi, Alfredo; Strigari, Lidia; Farsetti, Antonella; Nanni, Simona
Specific inhibitors of mitochondrial deacylase sirtuin 4 endowed with cellular activity
2024 Pannek, M.; Alhalabi, Z.; Tomaselli, D.; Menna, M.; Fiorentino, F.; Robaa, D.; Weyand, M.; Puhlmann, M.; Tomassi, S.; Barreca, F.; Tafani, M.; Zaganjor, E.; Haigis, M. C.; Sippl, W.; Rotili, D.; Mai, A.; Steegborn, C.
Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3
2024 Cesaro, Bianca; Iaiza, Alessia; Piscopo, Fabio; Tarullo, Marco; Cesari, Eleonora; Rotili, Dante; Mai, Antonello; Diana, Alberto; Londero, Michela; Del Giacco, Luca; Masetti, Riccardo; Di Leone, Alba; Naro, Chiara; Masciarelli, Silvia; Fontemaggi, Giulia; Sette, Claudio; Fazi, Francesco; Fatica, Alessandro
LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials
2023 Noce, Beatrice; Di Bello, Elisabetta; Fioravanti, Rossella; Mai, Antonello
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity
2023 Boissavy, Tom; Rotili, Dante; Mouveaux, Thomas; Roger, Emmanuel; Aliouat, El Moukthar; Pierrot, Christine; Valente, Sergio; Mai, Antonello; Gissot, Mathieu
PD-L1 small-molecule modulators: a new hope in epigenetic-based multidrug cancer therapy?
2023 Zwergel, Clemens; Fioravanti, Rossella; Mai, Antonello
Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages
2023 Noce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Masotti, Andrea; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Chakrabarti, Alokta; Romier, Christophe; Robaa, Dina; Sippl, Wolfgang; Jung, Manfred; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello
BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress
2023 Marchant, Vanessa; Trionfetti, Flavia; Tejedor-Santamaria, Lucia; Rayego-Mateos, Sandra; Rotili, Dante; Bontempi, Giulio; Domenici, Alessandro; Menè, Paolo; Mai, Antonello; Martín-Cleary, Catalina; Ortiz, Alberto; Ramos, Adrian M.; Strippoli, Raffaele; Ruiz-Ortega, Marta
Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection
2023 Fabbrizi, Emanuele; Fiorentino, Francesco; Carafa, Vincenzo; Altucci, Lucia; Mai, Antonello; Rotili, Dante
Targeting ROS production through inhibition of NADPH oxidases
2023 Reis, Joana; Gorgulla, Christoph; Massari, Marta; Marchese, Sara; Valente, Sergio; Noce, Beatrice; Basile, Lorenzo; Törner, Ricarda; Cox, Huel; Viennet, Thibault; Yang, Moon Hee; Ronan, Melissa M; Rees, Matthew G; Roth, Jennifer A; Capasso, Lucia; Nebbioso, Angela; Altucci, Lucia; Mai, Antonello; Arthanari, Haribabu; Mattevi, Andrea
Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells
2023 Negri, Aide; Marozzi, Marina; Trisciuoglio, Daniela; Rotili, Dante; Mai, Antonello; Rizzi, Federica
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells
2023 Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; DI BELLO, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells
2023 Trionfetti, Flavia; Alonzi, Tonino; Bontempi, Giulio; Terri, Michela; Battistelli, Cecilia; Montaldo, Claudia; Repele, Federica; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; Matusali, Giulia; Maggi, Fabrizio; Goletti, Delia; Tripodi, Marco; Mai, Antonello; Strippoli, Raffaele
SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells
2023 Wang, Jinping; Luo, Jinque; Rotili, Dante; Mai, Antonello; Steegborn, Clemens; Xu, Suowen; Jin, Zheng Gen
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells
2023 Di Bello, Elisabetta; Sian, Veronica; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Tomassi, Stefano; Corinti, Davide; Passeri, Daniela; Pellicciari, Roberto; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Tripodi, Marco; Strippoli, Raffaele; Nebbioso, Angela; Valente, Sergio; Mai, Antonello
Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence
2023 Zhou, Jujun; Horton, John R.; Menna, Martina; Fiorentino, Francesco; Ren, Ren; Yu, Dan; Hajian, Taraneh; Vedadi, Masoud; Mazzoccanti, Giulia; Ciogli, Alessia; Weinhold, Elmar; Hüben, Michael; Blumenthal, Robert M.; Zhang, Xing; Mai, Antonello; Rotili, Dante; Cheng, Xiaodong
Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation
2023 Fiorentino, Francesco; Rotili, Dante; Mai, Antonello
Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells
2023 Ansari, MOHAMMAD SALIK ZEYA; Stagni, Venturina; Iuzzolino, Angela; Rotili, Dante; Mai, Antonello; Del Bufalo, Donatella; Lavia, Patrizia; Degrassi, Francesca; Trisciuoglio, Daniela
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors
2023 Lambona, Chiara; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Mai, Antonello
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII
2023 Fiorentino, Francesco; Nocentini, Alessio; Rotili, Dante; Supuran, Claudiu T; Mai, Antonello
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design
2023 Castiello, Carola; Junghanns, Pierre; Mergel, Annika; Jacob, Claus; Ducho, Christian; Valente, Sergio; Rotili, Dante; Fioravanti, Rossella; Zwergel, Clemens; Mai, Antonello
The role of structural biology in the design of sirtuin activators
2023 Fiorentino, Francesco; Mai, Antonello; Rotili, Dante
First-in-class selective inhibitors of the lysine acetyltransferase KAT8
2023 Fiorentino, Francesco; Sementilli, Sara; Menna, Martina; Turrisi, Federica; Tomassi, Stefano; Pellegrini, FRANCESCA ROMANA; Iuzzolino, Angela; D'Acunzo, Francesca; Feoli, Alessandra; Wapenaar, Hannah; Taraglio, Sophie; Fraschetti, Caterina; Del Bufalo, Donatella; Sbardella, Gianluca; Dekker, Frank J.; Paiardini, Alessandro; Trisciuoglio, Daniela; Mai, Antonello; Rotili, Dante
SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS
2023 Barreca, Federica; Aventaggiato, Michele; Vitiello, Laura; Sansone, Luigi; Russo, Matteo Antonio; Mai, Antonello; Valente, Sergio; Tafani, Marco
State of the art of carbonic anhydrase activators
2023 Fiorentino, Francesco; Carta, Fabrizio; Rotili, Dante; Mai, Antonello; Supuran, Claudiu T
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa.
2023 Scribani Rossi, C; Eckartt, K; Scarchilli, E; Angeli, S; Price-Whelan, A; Di Matteo, A; Chevreuil, M; Raynal, B; Arcovito, A; Giacon, N; Fiorentino, F; Rotili, D; Mai, A; Espinosa-Urgel, M; Cutruzzola', F; Dietrich, Lep; Paone, A; Paiardini, A; Rinaldo, S
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase
2023 Zhou, Jujun; Deng, Youchao; Iyamu, Iredia D; Horton, John R; Yu, Dan; Hajian, Taraneh; Vedadi, Masoud; Rotili, Dante; Mai, Antonello; Blumenthal, Robert M; Zhang, Xing; Huang, Rong; Cheng, Xiaodong
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey
2023 Fiorentino, Francesco; Menna, Martina; Rotili, Dante; Valente, Sergio; Mai, Antonello
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery
2023 Aventaggiato, Michele; Barreca, Federica; Vitiello, Laura; Vespa, Simone; Valente, Sergio; Rotili, Dante; Mai, Antonello; Lotti, Lavinia Vittoria; Sansone, Luigi; Russo, Matteo A.; Bizzarri, Mariano; Ferretti, Elisabetta; Tafani, Marco
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity
2022 Fioravanti, Rossella; Rodriguez, Veronica; Caroli, Jonatan; Chianese, Ugo; Benedetti, Rosaria; Di Bello, Elisabetta; Noce, Beatrice; Zwergel, Clemens; Corinti, Davide; Viña, Dolores; Altucci, Lucia; Mattevi, Andrea; Valente, Sergio; Mai, Antonello
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models
2022 Menna, M.; Fiorentino, F.; Marrocco, B.; Lucidi, A.; Tomassi, S.; Cilli, D.; Romanenghi, M.; Cassandri, M.; Pomella, S.; Pezzella, M.; Del Bufalo, D.; Zeya Ansari, M. S.; Tomasevic, N.; Mladenovic, M.; Viviano, M.; Sbardella, G.; Rota, R.; Trisciuoglio, D.; Minucci, S.; Mattevi, A.; Rotili, D.; Mai, A.
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy
2022 Morroni, Jacopo; Schirone, Leonardo; Valenti, Valentina; Zwergel, Clemens; Riera, Carles Sánchez; Valente, Sergio; Vecchio, Daniele; Schiavon, Sonia; Ragno, Rino; Mai, Antonello; Sciarretta, Sebastiano; Lozanoska-Ochser, Biliana; Bouchè, Marina
Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics
2022 Chianese, Ugo; Papulino, Chiara; Passaro, Eugenia; Evers, Tom Mj; Babaei, Mehrad; Toraldo, Antonella; De Marchi, Tommaso; Niméus, Emma; Carafa, Vincenzo; Nicoletti, Maria Maddalena; Del Gaudio, Nunzio; Iaccarino, Nunzia; Randazzo, Antonio; Rotili, Dante; Mai, Antonello; Cappabianca, Salvatore; Mashaghi, Alireza; Ciardiello, Fortunato; Altucci, Lucia; Benedetti, Rosaria
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules
2022 Valentini, E.; D'Aguanno, S.; Di Martile, M.; Montesano, C.; Ferraresi, V.; Patsilinakos, A.; Sabatino, M.; Antonini, L.; Chiacchiarini, M.; Valente, S.; Mai, A.; Colotti, G.; Ragno, R.; Trisciuoglio, D.; Del Bufalo, D.
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells
2022 Bontempi, Giulio; Terri, Michela; Garbo, Sabrina; Montaldo, Claudia; Mariotti, Davide; Bordoni, Veronica; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Marchetti, Alessandra; Domenici, Alessandro; Menè, Paolo; Battistelli, Cecilia; Tripodi, Marco; Strippoli, Raffaele
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5
2022 Suenkel, Benjamin; Valente, Sergio; Zwergel, Clemens; Weiss, Sandra; DI BELLO, Elisabetta; Fioravanti, Rossella; Aventaggiato, Michele; Amorim, João A.; Garg, Neha; Kumar, Surinder; Lombard, David B.; Hu, Tuo; Singh, Pankaj K.; Tafani, Marco; Palmeira, Carlos M.; Sinclair, David; Mai, Antonello; Steegborn, Clemens
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy
2022 Renzini, A.; Marroncelli, N.; Cavioli, G.; Di Francescantonio, S.; Forcina, L.; Lambridis, A.; Di Giorgio, E.; Valente, S.; Mai, A.; Brancolini, C.; Giampietri, C.; Magenta, A.; De Santa, F.; Adamo, S.; Coletti, D.; Moresi, V.
Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro-adipogenic progenitors
2022 Consalvi, S.; Tucciarone, L.; Macri, E.; De Bardi, M.; Picozza, M.; Salvatori, I.; Renzini, A.; Valente, S.; Mai, A.; Moresi, V.; Puri, P. L.
A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression
2022 Mouveaux, T.; Rotili, D.; Boissavy, T.; Roger, E.; Pierrot, C.; Mai, A.; Gissot, M.
The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity
2022 Siciliano, G.; Di Paolo, V.; Rotili, D.; Migale, R.; Pedini, F.; Casella, M.; Camerini, S.; Dalzoppo, D.; Henderson, R.; Huijs, T.; Dechering, K. J.; Mai, A.; Caccuri, A. M.; Lalle, M.; Quintieri, L.; Alano, P.
Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies
2022 Taurone, Samanta; DE PONTE, Chiara; Rotili, Dante; DE SANTIS, Elena; Mai, Antonello; Fiorentino, Francesco; Scarpa, Susanna; Artico, Marco; Micera, Alessandra
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni
2022 Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Fianco, Giulia; Trisciuoglio, Daniela; Mourão, Marina M; Sales, Policarpo; Lamotte, Suzanne; Prina, Eric; Späth, Gerald F; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello
Modulation of virulence-associated traits in Aspergillus fumigatus by BET Inhibitor JQ1
2022 Orekhova, Anastasia; De Angelis, Marta; Cacciotti, Andrea; Reverberi, Massimo; Rotili, Dante; Giorgi, Alessandra; Protto, Virginia; Bonincontro, Graziana; Fiorentino, Francesco; Zgoda, Victor; Mai, Antonello; Palamara, Anna Teresa; Simonetti, Giovanna
Current HDAC Inhibitors in Clinical Trials
2022 DI BELLO, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Mai, Antonello
Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response
2022 Cristalli, C.; Manara, M. C.; Valente, S.; Pellegrini, E.; Bavelloni, A.; De Feo, A.; Blalock, W.; Di Bello, E.; Pineyro, D.; Merkel, A.; Esteller, M.; Tirado, O. M.; Mai, A.; Scotlandi, K.
Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5
2022 Fiorentino, F.; Castiello, C.; Mai, A.; Rotili, D.
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription
2022 Minisini, Martina; Di Giorgio, Eros; Kerschbamer, Emanuela; Dalla, Emiliano; Faggiani, Massimo; Franforte, Elisa; Meyer-Almes, Franz-Josef; Ragno, Rino; Antonini, Lorenzo; Mai, Antonello; Fiorentino, Francesco; Rotili, Dante; Chinellato, Monica; Perin, Stefano; Cendron, Laura; Weichenberger, Christian X; Angelini, Alessandro; Brancolini, Claudio
Sirtuin modulators: past, present, and future perspectives
2022 Fiorentino, Francesco; Mautone, Nicola; Menna, Martina; D'Acunzo, Francesca; Mai, Antonello; Rotili, Dante
Sirtuins
2021 Zwergel, Clemens; Tomaselli, Daniela; Mai, Antonello
JQ1, inibitore delle proteine BET, riduce i fattori di virulenza e la patogenicità di Aspergillus fumigatus.
2021 Orekhova, A.; De Angelis, M.; Protto, V.; Rotili, D.; Mai, A.; A. T., Palamara.; Simonetti, G
Histone-deacetylase 8 drives the immune response and the growth of glioma
2021 Mormino, Alessandro; Cocozza, Germana; Fontemaggi, Giulia; Valente, Sergio; Esposito, Vincenzo; Santoro, Antonio; Bernardini, Giovanni; Santoni, Angela; Fazi, Francesco; Mai, Antonello; Limatola, Cristina; Garofalo, Stefano
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders
2021 Tomassi, Stefano; Romanelli, Annalisa; Zwergel, Clemens; Valente, Sergio; Mai, Antonello
Sex-dependent effects of the drugs of abuse amphetamine and the smart drug 3,4-methylenedioxypyrovalerone on fear memory generalization in rats
2021 Riccardi, Eleonora; Blasi, Eleonora; Zwergel, Clemens; Mai, Antonello; Morena, Maria; Campolongo, Patrizia
Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein-protein interactions
2021 Fiorentino, F.; Rotili, D.; Mai, A.; Bolla, J. R.; Robinson, C. V.
Amphetamine modulation of long-term object recognition memory in rats: influence of stress
2021 Colucci, Paola; Santori, Alessia; Romanelli, Luca; Zwergel, Clemens; Mai, Antonello; Scaccianoce, Sergio; Campolongo, Patrizia
Sirt5 inhibition induces brown fat-like phenotype in 3t3-l1 preadipocytes
2021 Molinari, Francesca; Feraco, Alessandra; Mirabilii, Simone; Saladini, Serena; Sansone, Luigi; Vernucci, Enza; Tomaselli, Giada; Marzolla, Vincenzo; Rotili, Dante; A Russo, Matteo; Ricciardi, Maria Rosaria; Tafuri, Agostino; Mai, Antonello; Caprio, Massimiliano; Tafani, Marco; Armani, Andrea
Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity
2021 Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Conte, Mariarosaria; Nebbioso, Angela; Mazzone, Roberta; Brosch, Gerald; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Valente, Sergio; Mai, Antonello
The two-faced role of sirt6 in cancer
2021 Fiorentino, F.; Carafa, V.; Favale, G.; Altucci, L.; Mai, A.; Rotili, D.
Regulatory interplay between mir-181a-5p and estrogen receptor signaling cascade in breast cancer
2021 Benedetti, R.; Papulino, C.; Sgueglia, G.; Chianese, U.; De Marchi, T.; Iovino, F.; Rotili, D.; Mai, A.; Nimeus, E.; Aversana, C. D.; Altucci, L.
Emerging Therapeutic Potential of SIRT6 Modulators
2021 Fiorentino, F.; Mai, A.; Rotili, D.
Metabolic rewiring by loss of sirt5 promotes kras-induced pancreatic cancer progression
2021 Hu, T.; Shukla, S. K.; Vernucci, E.; He, C.; Wang, D.; King, R. J.; Jha, K.; Siddhanta, K.; Mullen, N. J.; Attri, K. S.; Murthy, D.; Chaika, N. V.; Thakur, R.; Mulder, S. E.; Pacheco, C. G.; Fu, X.; High, R. R.; Yu, F.; Lazenby, A.; Steegborn, C.; Lan, P.; Mehla, K.; Rotili, D.; Chaudhary, S.; Valente, S.; Tafani, M.; Mai, A.; Auwerx, J.; Verdin, E.; Tuveson, D.; Singh, P. K.
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53
2021 Nowak, R. P.; Tumber, A.; Hendrix, E.; Ansari, M. S. Z.; Sabatino, M.; Antonini, L.; Andrijes, R.; Salah, E.; Mautone, N.; Pellegrini, F. R.; Simelis, K.; Kawamura, A.; Johansson, C.; Passeri, D.; Pellicciari, R.; Ciogli, A.; Del Bufalo, D.; Ragno, R.; Coleman, M. L.; Trisciuoglio, D.; Mai, A.; Oppermann, U.; Schofield, C. J.; Rotili, D.
Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives
2021 Fiorentino, Francesco; DE ANGELIS, Marta; Menna, Martina; Rovere, Annarita; Maria Caccuri, Anna; D'Acunzo, Francesca; Palamara, ANNA TERESA; Nencioni, Lucia; Rotili, Dante; Mai, Antonello
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth
2021 Miele, Evelina; Po, Agnese; Mastronuzzi, Angela; Carai, Andrea; Besharat, Zein Mersini; Pediconi, Natalia; Abballe, Luana; Catanzaro, Giuseppina; Sabato, Claudia; De Smaele, Enrico; Canettieri, Gianluca; Di Marcotullio, Lucia; Vacca, Alessandra; Mai, Antonello; Levrero, Massimo; Pfister, Stefan M; Kool, Marcel; Giangaspero, Felice; Locatelli, Franco; Ferretti, Elisabetta
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni
2020 Coutinho Carneiro, V.; de Abreu da Silva, I. C.; Amaral, M. S.; Pereira, A. S. A.; Silveira, G. O.; Pires, D. D. S.; Verjovski-Almeida, S.; Dekker, F. J.; Rotili, D.; Mai, A.; Lopes-Torres, E. J.; Robaa, D.; Sippl, W.; Pierce, R. J.; Borrello, M. T.; Ganesan, A.; Lancelot, J.; Thiengo, S.; Fernandez, M. A.; Vicentino, A. R. R.; Mourao, M. M.; Coelho, F. S.; Fantappie, M. R.
Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes
2020 Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; Holanda Freitas-Junior, Lucio; Moraes, Carolina Borsoi; Ragno, Rino; Rotili, Dante; Schenkman, Sergio; Mai, Antonello; Silvio Moretti, Nilmar
The innovative potential of statins in cancer: new targets for new therapies
2020 Di Bello, Elisabetta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation
2020 Ravasio, R.; Ceccacci, E.; Nicosia, L.; Hosseini, A.; Rossi, P. L.; Barozzi, I.; Fornasari, L.; Zuffo, R. D.; Valente, S.; Fioravanti, R.; Mercurio, C.; Varasi, M.; Mattevi, A.; Mai, A.; Pavesi, G.; Bonaldi, T.; Minucci, S.
Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats
2020 Schiavi, Sara; Melancia, Francesca; Carbone, Emilia; Buzzelli, Valeria; Manduca, Antonia; Peinado, Patricia Jiménez; Zwergel, Clemens; Mai, Antonello; Campolongo, Patrizia; Vanderschuren, Louk J M J; Trezza, Viviana
From PARP1 to TNKS2 inhibition: A structure-based approach
2020 Tomassi, Stefano; Pfahler, Julian; Mautone, Nicola; Rovere, Annarita; Esposito, Chiara; Passeri, Daniela; Pellicciari, Roberto; Novellino, Ettore; Pannek, Martin; Steegborn, Clemens; Paiardini, Alessandro; Mai, Antonello; Rotili, Dante
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization
2020 Caroselli, Silvia; Zwergel, Clemens; Pirolli, Adele; Sabatino, Manuela; Xu, Zhanjie; Kirsch, Gilbert; Mai, Antonello; Colotti, Gianni; Altieri, Fabio; Canipari, Rita; Valente, Sergio; Ragno, Rino
The pan-sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line
2020 Carafa, Vincenzo; Russo, Rosita; Della Torre, Laura; Cuomo, Francesca; Dell'Aversana, Carmela; Sarno, Federica; Sgueglia, Giulia; Di Donato, Marzia; Rotili, Dante; Mai, Antonello; Nebbioso, Angela; Cobellis, Gilda; Chambery, Angela; Altucci, Lucia
CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas
2020 Cassandri, Matteo; Fioravanti, Rossella; Pomella, Silvia; Valente, Sergio; Rotili, Dante; DEL BALDO, Giada; De Angelis, Biagio; Rota, Rossella; Mai, Antonello
Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene
2020 Nobile, V.; Palumbo, F.; Lanni, S.; Ghisio, V.; Vitali, A.; Castagnola, M.; Marzano, V.; Maulucci, G.; De Angelis, C.; De Spirito, M.; Pacini, L.; D'Andrea, L.; Ragno, R.; Stazi, G.; Valente, S.; Mai, A.; Chiurazzi, P.; Genuardi, M.; Neri, G.; Tabolacci, E.
A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action
2020 Reis, J.; Massari, M.; Marchese, S.; Ceccon, M.; Aalbers, F. S.; Corana, F.; Valente, S.; Mai, A.; Magnani, F.; Mattevi, A.
Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs)
2020 Tomaselli, D.; Mautone, N.; Mai, A.; Rotili, D.
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
2020 Mautone, Nicola; Zwergel, Clemens; Mai, Antonello; Rotili, Dante
Properly substituted cyclic Bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 Inhibitors and Induced apoptosis in cancer cells
2020 Fioravanti, Rossella; Tomassi, Stefano; DI BELLO, Elisabetta; Romanelli, Annalisa; Plateroti, ANDREA MARIA; Benedetti, Rosaria; Conte, Mariarosaria; Novellino, Ettore; Altucci, Lucia; Valente, Sergio; Mai, Antonello
Sirt4: a multifaceted enzyme at the crossroads of mitochondrial metabolism and cancer
2020 Tomaselli, D.; Steegborn, C.; Mai, A.; Rotili, D.
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells
2020 Romanelli, Annalisa; Stazi, Giulia; Fioravanti, Rossella; Zwergel, Clemens; Di Bello, Elisabetta; Pomella, Silvia; Perrone, Clara; Battistelli, Cecilia; Strippoli, Raffaele; Tripodi, Marco; del Bufalo, Donatella; Rota, Rossella; Trisciuoglio, Daniela; Mai, Antonello; Valente, Sergio
HAT inhibitors in cancer therapy
2020 Fiorentino, Francesco; Mai, Antonello; Rotili, Dante
Lysine Acetyltransferase Inhibitors From Natural Sources
2020 Fiorentino, F.; Mai, A.; Rotili, D.
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation
2020 Zwergel, C.; Fioravanti, R.; Stazi, G.; Sarno, F.; Battistelli, C.; Romanelli, A.; Nebbioso, A.; Mendes, E.; Paulo, A.; Strippoli, R.; Tripodi, M.; Pechalrieu, D.; Arimondo, P. B.; De Luca, T.; Del Bufalo, D.; Trisciuoglio, D.; Altucci, L.; Valente, S.; Mai, A.
Diphenylene Iodonium Is a Noncovalent MAO Inhibitor: A Biochemical and Structural Analysis
2020 Iacovino, L. G.; Reis, J.; Mai, A.; Binda, C.; Mattevi, A.
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation
2020 Fioravanti, R.; Romanelli, A.; Mautone, N.; Di Bello, E.; Rovere, A.; Corinti, D.; Zwergel, C.; Valente, S.; Rotili, D.; Botrugno, O. A.; Dessanti, P.; Vultaggio, S.; Vianello, P.; Cappa, A.; Binda, C.; Mattevi, A.; Minucci, S.; Mercurio, C.; Varasi, M.; Mai, A.
Targeting histone acetylation/deacetylation in parasites: an update (2017–2020)
2020 Fioravanti, Rossella; Mautone, Nicola; Rovere, Annarita; Rotili, Dante; Mai, Antonello
Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells
2019 Sirotkin, A. V.; Adamcova, E.; Rotili, D.; Mai, A.; Mlyncek, M.; Mansour, L.; Alwasel, S.; Harrath, A. H.
Epigenetic modulators as a new strategies to reduce Aspergillus pathogenicity
2019 Orekhova, Anastasia; D’Auria, F. D.; Rotili, D.; Mai, A.; Palamara, A. T.; Simonetti, G
Sirtuins as drug targets
2019 Zwergel, Clemens; Rotili, Dante; Valente, Sergio; Mai, Antonello
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer
2019 Benedetti, R.; Dell'Aversana, C.; De Marchi, T.; Rotili, D.; Liu, N. Q.; Novakovic, B.; Boccella, S.; Di Maro, S.; Cosconati, S.; Baldi, A.; Nimeus, E.; Schultz, J.; Hoglund, U.; Maione, S.; Papulino, C.; Chianese, U.; Iovino, F.; Federico, A.; Mai, A.; Stunnenberg, H. G.; Nebbioso, A.; Altucci, L.
Epigenetic polypharmacology: a new frontier for epi-drug discovery
2019 Tomaselli, Daniela; Lucidi, Alessia; Rotili, Dante; Mai, Antonello
Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat
2019 ATEHORTUA MARTINEZ, LUISA ALESSANDRA; Masniere, Cyriaque; Campolongo, Patrizia; Chasseigneaux, Stéphanie; Callebert, Jacques; Zwergel, Clemens; Mai, Antonello; Laplanche, Jean-Louis; Chen, Huixiong; Etheve-Quelquejeu, Mélanie; Mégarbane, Bruno; Benturquia, Nadia
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells
2019 Favia, A.; Salvatori, L.; Nanni, S.; Iwamoto-Stohl, L. K.; Valente, S.; Mai, A.; Scagnoli, F.; Fontanella, R. A.; Totta, P.; Nasi, S.; Illi, B.
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
2019 Stazi, Giulia; Battistelli, Cecilia; Piano, Valentina; Mazzone, Roberta; Marrocco, Biagina; Marchese, Sara; Louie, Sharon M.; Zwergel, Clemens; Antonini, Lorenzo; Patsilinakos, Alexandros; Ragno, Rino; Viviano, Monica; Sbardella, Gianluca; Ciogli, Alessia; Fabrizi, Giancarlo; Cirilli, Roberto; Strippoli, Raffaele; Marchetti, Alessandra; Tripodi, Marco; Nomura, Daniel K.; Mattevi, Andrea; Mai, Antonello; Valente, Sergio
DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation
2019 Lucidi, Alessia; Tomaselli, Daniela; Rotili, Dante; Mai, Antonello
H19-dependent transcriptional regulation of β3 and β4 integrins upon estrogen and hypoxia favors metastatic potential in prostate cancer
2019 Bacci, L.; Aiello, A.; Ripoli, C.; Loria, R.; Pugliese, D.; Pierconti, F.; Rotili, D.; Strigari, L.; Pinto, F.; Bassi, P. F.; Mai, A.; Grassi, C.; Pontecorvi, A.; Falcioni, R.; Farsetti, A.; Nanni, S.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype | 2024 | Trionfetti, Flavia; Montaldo, Claudia; Caiello, Ivan; Bontempi, Giulio; Terri, Michela; Tiberi, Marta; Marchant, Vanessa; Domenici, Alessandro; Menè, Paolo; Cordani, Marco; Zwergel, Clemens; Prencipe, Giusi; Ruiz-Ortega, Marta; Valente, Sergio; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele | |
| Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy | 2024 | Villares, Marie; Lourenço, Nelly; Ktorza, Ivan; Berthelet, Jérémy; Panagiotou, Aristeidis; Richard, Aurélie; Amo, Angélique; Koziy, Yulianna; Medjkane, Souhila; Valente, Sergio; Fioravanti, Rossella; Pioche-Durieu, Catherine; Lignière, Laurent; Chevreux, Guillaume; Mai, Antonello; Weitzman, Jonathan B. | |
| HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling | 2024 | Terri, Michela; Sandoval, Pilar; Bontempi, Giulio; Montaldo, Claudia; Tomero-Sanz, Henar; de Turris, Valeria; Trionfetti, Flavia; Pascual-Antón, Lucía; Clares-Pedrero, Irene; Battistelli, Cecilia; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Rosanò, Laura; Del Pozo, Miguel Ángel; Sánchez-Álvarez, Miguel; Cabañas, Carlos; Tripodi, Marco; López-Cabrera, Manuel; Strippoli, Raffaele | |
| SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process | 2024 | Lambona, Chiara; Zwergel, Clemens; Valente, Sergio; Mai, Antonello | |
| Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer | 2024 | Pecci, Valeria; Troisi, Fabiola; Aiello, Aurora; De Martino, Sara; Carlino, Angela; Fiorentino, Vincenzo; Ripoli, Cristian; Rotili, Dante; Pierconti, Francesco; Martini, Maurizio; Porru, Manuela; Pinto, Francesco; Mai, Antonello; Bassi, Pier Francesco; Grassi, Claudio; Gaetano, Carlo; Pontecorvi, Alfredo; Strigari, Lidia; Farsetti, Antonella; Nanni, Simona | |
| Specific inhibitors of mitochondrial deacylase sirtuin 4 endowed with cellular activity | 2024 | Pannek, M.; Alhalabi, Z.; Tomaselli, D.; Menna, M.; Fiorentino, F.; Robaa, D.; Weyand, M.; Puhlmann, M.; Tomassi, S.; Barreca, F.; Tafani, M.; Zaganjor, E.; Haigis, M. C.; Sippl, W.; Rotili, D.; Mai, A.; Steegborn, C. | |
| Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3 | 2024 | Cesaro, Bianca; Iaiza, Alessia; Piscopo, Fabio; Tarullo, Marco; Cesari, Eleonora; Rotili, Dante; Mai, Antonello; Diana, Alberto; Londero, Michela; Del Giacco, Luca; Masetti, Riccardo; Di Leone, Alba; Naro, Chiara; Masciarelli, Silvia; Fontemaggi, Giulia; Sette, Claudio; Fazi, Francesco; Fatica, Alessandro | |
| LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials | 2023 | Noce, Beatrice; Di Bello, Elisabetta; Fioravanti, Rossella; Mai, Antonello | |
| Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity | 2023 | Boissavy, Tom; Rotili, Dante; Mouveaux, Thomas; Roger, Emmanuel; Aliouat, El Moukthar; Pierrot, Christine; Valente, Sergio; Mai, Antonello; Gissot, Mathieu | |
| PD-L1 small-molecule modulators: a new hope in epigenetic-based multidrug cancer therapy? | 2023 | Zwergel, Clemens; Fioravanti, Rossella; Mai, Antonello | |
| Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages | 2023 | Noce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Masotti, Andrea; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Chakrabarti, Alokta; Romier, Christophe; Robaa, Dina; Sippl, Wolfgang; Jung, Manfred; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello | |
| BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress | 2023 | Marchant, Vanessa; Trionfetti, Flavia; Tejedor-Santamaria, Lucia; Rayego-Mateos, Sandra; Rotili, Dante; Bontempi, Giulio; Domenici, Alessandro; Menè, Paolo; Mai, Antonello; Martín-Cleary, Catalina; Ortiz, Alberto; Ramos, Adrian M.; Strippoli, Raffaele; Ruiz-Ortega, Marta | |
| Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection | 2023 | Fabbrizi, Emanuele; Fiorentino, Francesco; Carafa, Vincenzo; Altucci, Lucia; Mai, Antonello; Rotili, Dante | |
| Targeting ROS production through inhibition of NADPH oxidases | 2023 | Reis, Joana; Gorgulla, Christoph; Massari, Marta; Marchese, Sara; Valente, Sergio; Noce, Beatrice; Basile, Lorenzo; Törner, Ricarda; Cox, Huel; Viennet, Thibault; Yang, Moon Hee; Ronan, Melissa M; Rees, Matthew G; Roth, Jennifer A; Capasso, Lucia; Nebbioso, Angela; Altucci, Lucia; Mai, Antonello; Arthanari, Haribabu; Mattevi, Andrea | |
| Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells | 2023 | Negri, Aide; Marozzi, Marina; Trisciuoglio, Daniela; Rotili, Dante; Mai, Antonello; Rizzi, Federica | |
| Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells | 2023 | Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; DI BELLO, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello | |
| HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells | 2023 | Trionfetti, Flavia; Alonzi, Tonino; Bontempi, Giulio; Terri, Michela; Battistelli, Cecilia; Montaldo, Claudia; Repele, Federica; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; Matusali, Giulia; Maggi, Fabrizio; Goletti, Delia; Tripodi, Marco; Mai, Antonello; Strippoli, Raffaele | |
| SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells | 2023 | Wang, Jinping; Luo, Jinque; Rotili, Dante; Mai, Antonello; Steegborn, Clemens; Xu, Suowen; Jin, Zheng Gen | |
| Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells | 2023 | Di Bello, Elisabetta; Sian, Veronica; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Tomassi, Stefano; Corinti, Davide; Passeri, Daniela; Pellicciari, Roberto; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Tripodi, Marco; Strippoli, Raffaele; Nebbioso, Angela; Valente, Sergio; Mai, Antonello | |
| Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence | 2023 | Zhou, Jujun; Horton, John R.; Menna, Martina; Fiorentino, Francesco; Ren, Ren; Yu, Dan; Hajian, Taraneh; Vedadi, Masoud; Mazzoccanti, Giulia; Ciogli, Alessia; Weinhold, Elmar; Hüben, Michael; Blumenthal, Robert M.; Zhang, Xing; Mai, Antonello; Rotili, Dante; Cheng, Xiaodong | |
| Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation | 2023 | Fiorentino, Francesco; Rotili, Dante; Mai, Antonello | |
| Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells | 2023 | Ansari, MOHAMMAD SALIK ZEYA; Stagni, Venturina; Iuzzolino, Angela; Rotili, Dante; Mai, Antonello; Del Bufalo, Donatella; Lavia, Patrizia; Degrassi, Francesca; Trisciuoglio, Daniela | |
| Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors | 2023 | Lambona, Chiara; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Mai, Antonello | |
| Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII | 2023 | Fiorentino, Francesco; Nocentini, Alessio; Rotili, Dante; Supuran, Claudiu T; Mai, Antonello | |
| GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design | 2023 | Castiello, Carola; Junghanns, Pierre; Mergel, Annika; Jacob, Claus; Ducho, Christian; Valente, Sergio; Rotili, Dante; Fioravanti, Rossella; Zwergel, Clemens; Mai, Antonello | |
| The role of structural biology in the design of sirtuin activators | 2023 | Fiorentino, Francesco; Mai, Antonello; Rotili, Dante | |
| First-in-class selective inhibitors of the lysine acetyltransferase KAT8 | 2023 | Fiorentino, Francesco; Sementilli, Sara; Menna, Martina; Turrisi, Federica; Tomassi, Stefano; Pellegrini, FRANCESCA ROMANA; Iuzzolino, Angela; D'Acunzo, Francesca; Feoli, Alessandra; Wapenaar, Hannah; Taraglio, Sophie; Fraschetti, Caterina; Del Bufalo, Donatella; Sbardella, Gianluca; Dekker, Frank J.; Paiardini, Alessandro; Trisciuoglio, Daniela; Mai, Antonello; Rotili, Dante | |
| SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS | 2023 | Barreca, Federica; Aventaggiato, Michele; Vitiello, Laura; Sansone, Luigi; Russo, Matteo Antonio; Mai, Antonello; Valente, Sergio; Tafani, Marco | |
| State of the art of carbonic anhydrase activators | 2023 | Fiorentino, Francesco; Carta, Fabrizio; Rotili, Dante; Mai, Antonello; Supuran, Claudiu T | |
| Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa. | 2023 | Scribani Rossi, C; Eckartt, K; Scarchilli, E; Angeli, S; Price-Whelan, A; Di Matteo, A; Chevreuil, M; Raynal, B; Arcovito, A; Giacon, N; Fiorentino, F; Rotili, D; Mai, A; Espinosa-Urgel, M; Cutruzzola', F; Dietrich, Lep; Paone, A; Paiardini, A; Rinaldo, S | |
| Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase | 2023 | Zhou, Jujun; Deng, Youchao; Iyamu, Iredia D; Horton, John R; Yu, Dan; Hajian, Taraneh; Vedadi, Masoud; Rotili, Dante; Mai, Antonello; Blumenthal, Robert M; Zhang, Xing; Huang, Rong; Cheng, Xiaodong | |
| METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey | 2023 | Fiorentino, Francesco; Menna, Martina; Rotili, Dante; Valente, Sergio; Mai, Antonello | |
| Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery | 2023 | Aventaggiato, Michele; Barreca, Federica; Vitiello, Laura; Vespa, Simone; Valente, Sergio; Rotili, Dante; Mai, Antonello; Lotti, Lavinia Vittoria; Sansone, Luigi; Russo, Matteo A.; Bizzarri, Mariano; Ferretti, Elisabetta; Tafani, Marco | |
| Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity | 2022 | Fioravanti, Rossella; Rodriguez, Veronica; Caroli, Jonatan; Chianese, Ugo; Benedetti, Rosaria; Di Bello, Elisabetta; Noce, Beatrice; Zwergel, Clemens; Corinti, Davide; Viña, Dolores; Altucci, Lucia; Mattevi, Andrea; Valente, Sergio; Mai, Antonello | |
| Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models | 2022 | Menna, M.; Fiorentino, F.; Marrocco, B.; Lucidi, A.; Tomassi, S.; Cilli, D.; Romanenghi, M.; Cassandri, M.; Pomella, S.; Pezzella, M.; Del Bufalo, D.; Zeya Ansari, M. S.; Tomasevic, N.; Mladenovic, M.; Viviano, M.; Sbardella, G.; Rota, R.; Trisciuoglio, D.; Minucci, S.; Mattevi, A.; Rotili, D.; Mai, A. | |
| Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy | 2022 | Morroni, Jacopo; Schirone, Leonardo; Valenti, Valentina; Zwergel, Clemens; Riera, Carles Sánchez; Valente, Sergio; Vecchio, Daniele; Schiavon, Sonia; Ragno, Rino; Mai, Antonello; Sciarretta, Sebastiano; Lozanoska-Ochser, Biliana; Bouchè, Marina | |
| Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics | 2022 | Chianese, Ugo; Papulino, Chiara; Passaro, Eugenia; Evers, Tom Mj; Babaei, Mehrad; Toraldo, Antonella; De Marchi, Tommaso; Niméus, Emma; Carafa, Vincenzo; Nicoletti, Maria Maddalena; Del Gaudio, Nunzio; Iaccarino, Nunzia; Randazzo, Antonio; Rotili, Dante; Mai, Antonello; Cappabianca, Salvatore; Mashaghi, Alireza; Ciardiello, Fortunato; Altucci, Lucia; Benedetti, Rosaria | |
| Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules | 2022 | Valentini, E.; D'Aguanno, S.; Di Martile, M.; Montesano, C.; Ferraresi, V.; Patsilinakos, A.; Sabatino, M.; Antonini, L.; Chiacchiarini, M.; Valente, S.; Mai, A.; Colotti, G.; Ragno, R.; Trisciuoglio, D.; Del Bufalo, D. | |
| Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells | 2022 | Bontempi, Giulio; Terri, Michela; Garbo, Sabrina; Montaldo, Claudia; Mariotti, Davide; Bordoni, Veronica; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Marchetti, Alessandra; Domenici, Alessandro; Menè, Paolo; Battistelli, Cecilia; Tripodi, Marco; Strippoli, Raffaele | |
| Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 | 2022 | Suenkel, Benjamin; Valente, Sergio; Zwergel, Clemens; Weiss, Sandra; DI BELLO, Elisabetta; Fioravanti, Rossella; Aventaggiato, Michele; Amorim, João A.; Garg, Neha; Kumar, Surinder; Lombard, David B.; Hu, Tuo; Singh, Pankaj K.; Tafani, Marco; Palmeira, Carlos M.; Sinclair, David; Mai, Antonello; Steegborn, Clemens | |
| Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy | 2022 | Renzini, A.; Marroncelli, N.; Cavioli, G.; Di Francescantonio, S.; Forcina, L.; Lambridis, A.; Di Giorgio, E.; Valente, S.; Mai, A.; Brancolini, C.; Giampietri, C.; Magenta, A.; De Santa, F.; Adamo, S.; Coletti, D.; Moresi, V. | |
| Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro-adipogenic progenitors | 2022 | Consalvi, S.; Tucciarone, L.; Macri, E.; De Bardi, M.; Picozza, M.; Salvatori, I.; Renzini, A.; Valente, S.; Mai, A.; Moresi, V.; Puri, P. L. | |
| A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression | 2022 | Mouveaux, T.; Rotili, D.; Boissavy, T.; Roger, E.; Pierrot, C.; Mai, A.; Gissot, M. | |
| The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity | 2022 | Siciliano, G.; Di Paolo, V.; Rotili, D.; Migale, R.; Pedini, F.; Casella, M.; Camerini, S.; Dalzoppo, D.; Henderson, R.; Huijs, T.; Dechering, K. J.; Mai, A.; Caccuri, A. M.; Lalle, M.; Quintieri, L.; Alano, P. | |
| Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies | 2022 | Taurone, Samanta; DE PONTE, Chiara; Rotili, Dante; DE SANTIS, Elena; Mai, Antonello; Fiorentino, Francesco; Scarpa, Susanna; Artico, Marco; Micera, Alessandra | |
| Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni | 2022 | Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Fianco, Giulia; Trisciuoglio, Daniela; Mourão, Marina M; Sales, Policarpo; Lamotte, Suzanne; Prina, Eric; Späth, Gerald F; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello | |
| Modulation of virulence-associated traits in Aspergillus fumigatus by BET Inhibitor JQ1 | 2022 | Orekhova, Anastasia; De Angelis, Marta; Cacciotti, Andrea; Reverberi, Massimo; Rotili, Dante; Giorgi, Alessandra; Protto, Virginia; Bonincontro, Graziana; Fiorentino, Francesco; Zgoda, Victor; Mai, Antonello; Palamara, Anna Teresa; Simonetti, Giovanna | |
| Current HDAC Inhibitors in Clinical Trials | 2022 | DI BELLO, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Mai, Antonello | |
| Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response | 2022 | Cristalli, C.; Manara, M. C.; Valente, S.; Pellegrini, E.; Bavelloni, A.; De Feo, A.; Blalock, W.; Di Bello, E.; Pineyro, D.; Merkel, A.; Esteller, M.; Tirado, O. M.; Mai, A.; Scotlandi, K. | |
| Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5 | 2022 | Fiorentino, F.; Castiello, C.; Mai, A.; Rotili, D. | |
| Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription | 2022 | Minisini, Martina; Di Giorgio, Eros; Kerschbamer, Emanuela; Dalla, Emiliano; Faggiani, Massimo; Franforte, Elisa; Meyer-Almes, Franz-Josef; Ragno, Rino; Antonini, Lorenzo; Mai, Antonello; Fiorentino, Francesco; Rotili, Dante; Chinellato, Monica; Perin, Stefano; Cendron, Laura; Weichenberger, Christian X; Angelini, Alessandro; Brancolini, Claudio | |
| Sirtuin modulators: past, present, and future perspectives | 2022 | Fiorentino, Francesco; Mautone, Nicola; Menna, Martina; D'Acunzo, Francesca; Mai, Antonello; Rotili, Dante | |
| Sirtuins | 2021 | Zwergel, Clemens; Tomaselli, Daniela; Mai, Antonello | |
| JQ1, inibitore delle proteine BET, riduce i fattori di virulenza e la patogenicità di Aspergillus fumigatus. | 2021 | Orekhova, A.; De Angelis, M.; Protto, V.; Rotili, D.; Mai, A.; A. T., Palamara.; Simonetti, G | |
| Histone-deacetylase 8 drives the immune response and the growth of glioma | 2021 | Mormino, Alessandro; Cocozza, Germana; Fontemaggi, Giulia; Valente, Sergio; Esposito, Vincenzo; Santoro, Antonio; Bernardini, Giovanni; Santoni, Angela; Fazi, Francesco; Mai, Antonello; Limatola, Cristina; Garofalo, Stefano | |
| Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders | 2021 | Tomassi, Stefano; Romanelli, Annalisa; Zwergel, Clemens; Valente, Sergio; Mai, Antonello | |
| Sex-dependent effects of the drugs of abuse amphetamine and the smart drug 3,4-methylenedioxypyrovalerone on fear memory generalization in rats | 2021 | Riccardi, Eleonora; Blasi, Eleonora; Zwergel, Clemens; Mai, Antonello; Morena, Maria; Campolongo, Patrizia | |
| Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein-protein interactions | 2021 | Fiorentino, F.; Rotili, D.; Mai, A.; Bolla, J. R.; Robinson, C. V. | |
| Amphetamine modulation of long-term object recognition memory in rats: influence of stress | 2021 | Colucci, Paola; Santori, Alessia; Romanelli, Luca; Zwergel, Clemens; Mai, Antonello; Scaccianoce, Sergio; Campolongo, Patrizia | |
| Sirt5 inhibition induces brown fat-like phenotype in 3t3-l1 preadipocytes | 2021 | Molinari, Francesca; Feraco, Alessandra; Mirabilii, Simone; Saladini, Serena; Sansone, Luigi; Vernucci, Enza; Tomaselli, Giada; Marzolla, Vincenzo; Rotili, Dante; A Russo, Matteo; Ricciardi, Maria Rosaria; Tafuri, Agostino; Mai, Antonello; Caprio, Massimiliano; Tafani, Marco; Armani, Andrea | |
| Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity | 2021 | Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Conte, Mariarosaria; Nebbioso, Angela; Mazzone, Roberta; Brosch, Gerald; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Valente, Sergio; Mai, Antonello | |
| The two-faced role of sirt6 in cancer | 2021 | Fiorentino, F.; Carafa, V.; Favale, G.; Altucci, L.; Mai, A.; Rotili, D. | |
| Regulatory interplay between mir-181a-5p and estrogen receptor signaling cascade in breast cancer | 2021 | Benedetti, R.; Papulino, C.; Sgueglia, G.; Chianese, U.; De Marchi, T.; Iovino, F.; Rotili, D.; Mai, A.; Nimeus, E.; Aversana, C. D.; Altucci, L. | |
| Emerging Therapeutic Potential of SIRT6 Modulators | 2021 | Fiorentino, F.; Mai, A.; Rotili, D. | |
| Metabolic rewiring by loss of sirt5 promotes kras-induced pancreatic cancer progression | 2021 | Hu, T.; Shukla, S. K.; Vernucci, E.; He, C.; Wang, D.; King, R. J.; Jha, K.; Siddhanta, K.; Mullen, N. J.; Attri, K. S.; Murthy, D.; Chaika, N. V.; Thakur, R.; Mulder, S. E.; Pacheco, C. G.; Fu, X.; High, R. R.; Yu, F.; Lazenby, A.; Steegborn, C.; Lan, P.; Mehla, K.; Rotili, D.; Chaudhary, S.; Valente, S.; Tafani, M.; Mai, A.; Auwerx, J.; Verdin, E.; Tuveson, D.; Singh, P. K. | |
| First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53 | 2021 | Nowak, R. P.; Tumber, A.; Hendrix, E.; Ansari, M. S. Z.; Sabatino, M.; Antonini, L.; Andrijes, R.; Salah, E.; Mautone, N.; Pellegrini, F. R.; Simelis, K.; Kawamura, A.; Johansson, C.; Passeri, D.; Pellicciari, R.; Ciogli, A.; Del Bufalo, D.; Ragno, R.; Coleman, M. L.; Trisciuoglio, D.; Mai, A.; Oppermann, U.; Schofield, C. J.; Rotili, D. | |
| Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives | 2021 | Fiorentino, Francesco; DE ANGELIS, Marta; Menna, Martina; Rovere, Annarita; Maria Caccuri, Anna; D'Acunzo, Francesca; Palamara, ANNA TERESA; Nencioni, Lucia; Rotili, Dante; Mai, Antonello | |
| Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth | 2021 | Miele, Evelina; Po, Agnese; Mastronuzzi, Angela; Carai, Andrea; Besharat, Zein Mersini; Pediconi, Natalia; Abballe, Luana; Catanzaro, Giuseppina; Sabato, Claudia; De Smaele, Enrico; Canettieri, Gianluca; Di Marcotullio, Lucia; Vacca, Alessandra; Mai, Antonello; Levrero, Massimo; Pfister, Stefan M; Kool, Marcel; Giangaspero, Felice; Locatelli, Franco; Ferretti, Elisabetta | |
| Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni | 2020 | Coutinho Carneiro, V.; de Abreu da Silva, I. C.; Amaral, M. S.; Pereira, A. S. A.; Silveira, G. O.; Pires, D. D. S.; Verjovski-Almeida, S.; Dekker, F. J.; Rotili, D.; Mai, A.; Lopes-Torres, E. J.; Robaa, D.; Sippl, W.; Pierce, R. J.; Borrello, M. T.; Ganesan, A.; Lancelot, J.; Thiengo, S.; Fernandez, M. A.; Vicentino, A. R. R.; Mourao, M. M.; Coelho, F. S.; Fantappie, M. R. | |
| Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes | 2020 | Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; Holanda Freitas-Junior, Lucio; Moraes, Carolina Borsoi; Ragno, Rino; Rotili, Dante; Schenkman, Sergio; Mai, Antonello; Silvio Moretti, Nilmar | |
| The innovative potential of statins in cancer: new targets for new therapies | 2020 | Di Bello, Elisabetta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio | |
| Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation | 2020 | Ravasio, R.; Ceccacci, E.; Nicosia, L.; Hosseini, A.; Rossi, P. L.; Barozzi, I.; Fornasari, L.; Zuffo, R. D.; Valente, S.; Fioravanti, R.; Mercurio, C.; Varasi, M.; Mattevi, A.; Mai, A.; Pavesi, G.; Bonaldi, T.; Minucci, S. | |
| Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats | 2020 | Schiavi, Sara; Melancia, Francesca; Carbone, Emilia; Buzzelli, Valeria; Manduca, Antonia; Peinado, Patricia Jiménez; Zwergel, Clemens; Mai, Antonello; Campolongo, Patrizia; Vanderschuren, Louk J M J; Trezza, Viviana | |
| From PARP1 to TNKS2 inhibition: A structure-based approach | 2020 | Tomassi, Stefano; Pfahler, Julian; Mautone, Nicola; Rovere, Annarita; Esposito, Chiara; Passeri, Daniela; Pellicciari, Roberto; Novellino, Ettore; Pannek, Martin; Steegborn, Clemens; Paiardini, Alessandro; Mai, Antonello; Rotili, Dante | |
| Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization | 2020 | Caroselli, Silvia; Zwergel, Clemens; Pirolli, Adele; Sabatino, Manuela; Xu, Zhanjie; Kirsch, Gilbert; Mai, Antonello; Colotti, Gianni; Altieri, Fabio; Canipari, Rita; Valente, Sergio; Ragno, Rino | |
| The pan-sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line | 2020 | Carafa, Vincenzo; Russo, Rosita; Della Torre, Laura; Cuomo, Francesca; Dell'Aversana, Carmela; Sarno, Federica; Sgueglia, Giulia; Di Donato, Marzia; Rotili, Dante; Mai, Antonello; Nebbioso, Angela; Cobellis, Gilda; Chambery, Angela; Altucci, Lucia | |
| CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas | 2020 | Cassandri, Matteo; Fioravanti, Rossella; Pomella, Silvia; Valente, Sergio; Rotili, Dante; DEL BALDO, Giada; De Angelis, Biagio; Rota, Rossella; Mai, Antonello | |
| Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene | 2020 | Nobile, V.; Palumbo, F.; Lanni, S.; Ghisio, V.; Vitali, A.; Castagnola, M.; Marzano, V.; Maulucci, G.; De Angelis, C.; De Spirito, M.; Pacini, L.; D'Andrea, L.; Ragno, R.; Stazi, G.; Valente, S.; Mai, A.; Chiurazzi, P.; Genuardi, M.; Neri, G.; Tabolacci, E. | |
| A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action | 2020 | Reis, J.; Massari, M.; Marchese, S.; Ceccon, M.; Aalbers, F. S.; Corana, F.; Valente, S.; Mai, A.; Magnani, F.; Mattevi, A. | |
| Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs) | 2020 | Tomaselli, D.; Mautone, N.; Mai, A.; Rotili, D. | |
| Sirtuin modulators: where are we now? A review of patents from 2015 to 2019 | 2020 | Mautone, Nicola; Zwergel, Clemens; Mai, Antonello; Rotili, Dante | |
| Properly substituted cyclic Bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 Inhibitors and Induced apoptosis in cancer cells | 2020 | Fioravanti, Rossella; Tomassi, Stefano; DI BELLO, Elisabetta; Romanelli, Annalisa; Plateroti, ANDREA MARIA; Benedetti, Rosaria; Conte, Mariarosaria; Novellino, Ettore; Altucci, Lucia; Valente, Sergio; Mai, Antonello | |
| Sirt4: a multifaceted enzyme at the crossroads of mitochondrial metabolism and cancer | 2020 | Tomaselli, D.; Steegborn, C.; Mai, A.; Rotili, D. | |
| Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells | 2020 | Romanelli, Annalisa; Stazi, Giulia; Fioravanti, Rossella; Zwergel, Clemens; Di Bello, Elisabetta; Pomella, Silvia; Perrone, Clara; Battistelli, Cecilia; Strippoli, Raffaele; Tripodi, Marco; del Bufalo, Donatella; Rota, Rossella; Trisciuoglio, Daniela; Mai, Antonello; Valente, Sergio | |
| HAT inhibitors in cancer therapy | 2020 | Fiorentino, Francesco; Mai, Antonello; Rotili, Dante | |
| Lysine Acetyltransferase Inhibitors From Natural Sources | 2020 | Fiorentino, F.; Mai, A.; Rotili, D. | |
| Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation | 2020 | Zwergel, C.; Fioravanti, R.; Stazi, G.; Sarno, F.; Battistelli, C.; Romanelli, A.; Nebbioso, A.; Mendes, E.; Paulo, A.; Strippoli, R.; Tripodi, M.; Pechalrieu, D.; Arimondo, P. B.; De Luca, T.; Del Bufalo, D.; Trisciuoglio, D.; Altucci, L.; Valente, S.; Mai, A. | |
| Diphenylene Iodonium Is a Noncovalent MAO Inhibitor: A Biochemical and Structural Analysis | 2020 | Iacovino, L. G.; Reis, J.; Mai, A.; Binda, C.; Mattevi, A. | |
| Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation | 2020 | Fioravanti, R.; Romanelli, A.; Mautone, N.; Di Bello, E.; Rovere, A.; Corinti, D.; Zwergel, C.; Valente, S.; Rotili, D.; Botrugno, O. A.; Dessanti, P.; Vultaggio, S.; Vianello, P.; Cappa, A.; Binda, C.; Mattevi, A.; Minucci, S.; Mercurio, C.; Varasi, M.; Mai, A. | |
| Targeting histone acetylation/deacetylation in parasites: an update (2017–2020) | 2020 | Fioravanti, Rossella; Mautone, Nicola; Rovere, Annarita; Rotili, Dante; Mai, Antonello | |
| Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells | 2019 | Sirotkin, A. V.; Adamcova, E.; Rotili, D.; Mai, A.; Mlyncek, M.; Mansour, L.; Alwasel, S.; Harrath, A. H. | |
| Epigenetic modulators as a new strategies to reduce Aspergillus pathogenicity | 2019 | Orekhova, Anastasia; D’Auria, F. D.; Rotili, D.; Mai, A.; Palamara, A. T.; Simonetti, G | |
| Sirtuins as drug targets | 2019 | Zwergel, Clemens; Rotili, Dante; Valente, Sergio; Mai, Antonello | |
| Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer | 2019 | Benedetti, R.; Dell'Aversana, C.; De Marchi, T.; Rotili, D.; Liu, N. Q.; Novakovic, B.; Boccella, S.; Di Maro, S.; Cosconati, S.; Baldi, A.; Nimeus, E.; Schultz, J.; Hoglund, U.; Maione, S.; Papulino, C.; Chianese, U.; Iovino, F.; Federico, A.; Mai, A.; Stunnenberg, H. G.; Nebbioso, A.; Altucci, L. | |
| Epigenetic polypharmacology: a new frontier for epi-drug discovery | 2019 | Tomaselli, Daniela; Lucidi, Alessia; Rotili, Dante; Mai, Antonello | |
| Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat | 2019 | ATEHORTUA MARTINEZ, LUISA ALESSANDRA; Masniere, Cyriaque; Campolongo, Patrizia; Chasseigneaux, Stéphanie; Callebert, Jacques; Zwergel, Clemens; Mai, Antonello; Laplanche, Jean-Louis; Chen, Huixiong; Etheve-Quelquejeu, Mélanie; Mégarbane, Bruno; Benturquia, Nadia | |
| The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells | 2019 | Favia, A.; Salvatori, L.; Nanni, S.; Iwamoto-Stohl, L. K.; Valente, S.; Mai, A.; Scagnoli, F.; Fontanella, R. A.; Totta, P.; Nasi, S.; Illi, B. | |
| Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells | 2019 | Stazi, Giulia; Battistelli, Cecilia; Piano, Valentina; Mazzone, Roberta; Marrocco, Biagina; Marchese, Sara; Louie, Sharon M.; Zwergel, Clemens; Antonini, Lorenzo; Patsilinakos, Alexandros; Ragno, Rino; Viviano, Monica; Sbardella, Gianluca; Ciogli, Alessia; Fabrizi, Giancarlo; Cirilli, Roberto; Strippoli, Raffaele; Marchetti, Alessandra; Tripodi, Marco; Nomura, Daniel K.; Mattevi, Andrea; Mai, Antonello; Valente, Sergio | |
| DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation | 2019 | Lucidi, Alessia; Tomaselli, Daniela; Rotili, Dante; Mai, Antonello | |
| H19-dependent transcriptional regulation of β3 and β4 integrins upon estrogen and hypoxia favors metastatic potential in prostate cancer | 2019 | Bacci, L.; Aiello, A.; Ripoli, C.; Loria, R.; Pugliese, D.; Pierconti, F.; Rotili, D.; Strigari, L.; Pinto, F.; Bassi, P. F.; Mai, A.; Grassi, C.; Pontecorvi, A.; Falcioni, R.; Farsetti, A.; Nanni, S. |
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