Sfoglia per Autore ZWERGEL, CLEMENS
Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype
2024 Trionfetti, Flavia; Montaldo, Claudia; Caiello, Ivan; Bontempi, Giulio; Terri, Michela; Tiberi, Marta; Marchant, Vanessa; Domenici, Alessandro; Menè, Paolo; Cordani, Marco; Zwergel, Clemens; Prencipe, Giusi; Ruiz-Ortega, Marta; Valente, Sergio; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease
2024 Pyka, Patryk; Haberek, Wawrzyniec; Więcek, Małgorzata; Szymanska, Ewa; Ali, Wesam; Cios, Agnieszka; Jastrzębska-Więsek, Magdalena; Satała, Grzegorz; Podlewska, Sabina; Di Giacomo, Silvia; Di Sotto, Antonella; Garbo, Sabrina; Karcz, Tadeusz; Lambona, Chiara; Marocco, Francesco; Latacz, Gniewomir; Sudoł-Tałaj, Sylwia; Mordyl, Barbara; Głuch-Lutwin, Monika; Siwek, Agata; Czarnota-Łydka, Kinga; Gogola, Dawid; Olejarz-Maciej, Agnieszka; Wilczyńska-Zawal, Natalia; Honkisz-Orzechowska, Ewelina; Starek, Małgorzata; Dąbrowska, Monika; Kucwaj-Brysz, Katarzyna; Fioravanti, Rossella; Nasim, Muhammad Jawad; Hittinger, Marius; Partyka, Anna; Wesołowska, Anna; Battistelli, Cecilia; Zwergel, Clemens; Handzlik, Jadwiga
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling
2024 Terri, Michela; Sandoval, Pilar; Bontempi, Giulio; Montaldo, Claudia; Tomero-Sanz, Henar; de Turris, Valeria; Trionfetti, Flavia; Pascual-Antón, Lucía; Clares-Pedrero, Irene; Battistelli, Cecilia; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Rosanò, Laura; Del Pozo, Miguel Ángel; Sánchez-Álvarez, Miguel; Cabañas, Carlos; Tripodi, Marco; López-Cabrera, Manuel; Strippoli, Raffaele
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process
2024 Lambona, Chiara; Zwergel, Clemens; Valente, Sergio; Mai, Antonello
Selenium-Containing Agents Acting on Cancer—A New Hope?
2023 Garbo, Sabrina; Di Giacomo, Silvia; Łażewska, Dorota; Honkisz-Orzechowska, Ewelina; Di Sotto, Antonella; Fioravanti, Rossella; Zwergel, Clemens; Battistelli, Cecilia
PD-L1 small-molecule modulators: a new hope in epigenetic-based multidrug cancer therapy?
2023 Zwergel, Clemens; Fioravanti, Rossella; Mai, Antonello
Editorial: Frontiers in Chemistry: rising stars 2022
2023 Brites, Carlos D. S.; Contini, Daniele; He, Xiao-Peng; Liu, Tianqing; Moosa, Basem; Pannico, Marianna; Rashed, Mohamed Nageeb; Qiu, Yunping; Zwergel, Clemens
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design
2023 Castiello, Carola; Junghanns, Pierre; Mergel, Annika; Jacob, Claus; Ducho, Christian; Valente, Sergio; Rotili, Dante; Fioravanti, Rossella; Zwergel, Clemens; Mai, Antonello
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells
2023 Trionfetti, Flavia; Alonzi, Tonino; Bontempi, Giulio; Terri, Michela; Battistelli, Cecilia; Montaldo, Claudia; Repele, Federica; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; Matusali, Giulia; Maggi, Fabrizio; Goletti, Delia; Tripodi, Marco; Mai, Antonello; Strippoli, Raffaele
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells
2023 Di Bello, Elisabetta; Sian, Veronica; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Tomassi, Stefano; Corinti, Davide; Passeri, Daniela; Pellicciari, Roberto; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Tripodi, Marco; Strippoli, Raffaele; Nebbioso, Angela; Valente, Sergio; Mai, Antonello
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells
2023 Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; DI BELLO, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors
2023 Lambona, Chiara; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Mai, Antonello
Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages
2023 Noce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Masotti, Andrea; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Chakrabarti, Alokta; Romier, Christophe; Robaa, Dina; Sippl, Wolfgang; Jung, Manfred; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity
2022 Fioravanti, Rossella; Rodriguez, Veronica; Caroli, Jonatan; Chianese, Ugo; Benedetti, Rosaria; Di Bello, Elisabetta; Noce, Beatrice; Zwergel, Clemens; Corinti, Davide; Viña, Dolores; Altucci, Lucia; Mattevi, Andrea; Valente, Sergio; Mai, Antonello
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5
2022 Suenkel, Benjamin; Valente, Sergio; Zwergel, Clemens; Weiss, Sandra; DI BELLO, Elisabetta; Fioravanti, Rossella; Aventaggiato, Michele; Amorim, João A.; Garg, Neha; Kumar, Surinder; Lombard, David B.; Hu, Tuo; Singh, Pankaj K.; Tafani, Marco; Palmeira, Carlos M.; Sinclair, David; Mai, Antonello; Steegborn, Clemens
Editorial: Multi-target directed ligands for the treatment of cancer
2022 Brindisi, Margherita; Kessler, Sonja M.; Kumar, Vinod; Zwergel, Clemens
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni
2022 Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Fianco, Giulia; Trisciuoglio, Daniela; Mourão, Marina M; Sales, Policarpo; Lamotte, Suzanne; Prina, Eric; Späth, Gerald F; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma
2022 Ali, Wesam; Garbo, Sabrina; Kincses, Annamária; Nové, Márta; Spengler, Gabriella; Di Bello, Elisabetta; Honkisz-Orzechowska, Ewelina; Karcz, Tadeusz; Szymańska, Ewa; Żesławska, Ewa; Starek, Małgorzata; Dąbrowska, Monika; Nitek, Wojciech; Kucwaj-Brysz, Katarzyna; Pyka, Patryk; Fioravanti, Rossella; Jacob, Claus; Battistelli, Cecilia; Zwergel, Clemens; Handzlik, Jadwiga
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells
2022 Bontempi, Giulio; Terri, Michela; Garbo, Sabrina; Montaldo, Claudia; Mariotti, Davide; Bordoni, Veronica; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Marchetti, Alessandra; Domenici, Alessandro; Menè, Paolo; Battistelli, Cecilia; Tripodi, Marco; Strippoli, Raffaele
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy
2022 Morroni, Jacopo; Schirone, Leonardo; Valenti, Valentina; Zwergel, Clemens; Riera, Carles Sánchez; Valente, Sergio; Vecchio, Daniele; Schiavon, Sonia; Ragno, Rino; Mai, Antonello; Sciarretta, Sebastiano; Lozanoska-Ochser, Biliana; Bouchè, Marina
Sirtuins
2021 Zwergel, Clemens; Tomaselli, Daniela; Mai, Antonello
Amphetamine modulation of long-term object recognition memory in rats: influence of stress
2021 Colucci, Paola; Santori, Alessia; Romanelli, Luca; Zwergel, Clemens; Mai, Antonello; Scaccianoce, Sergio; Campolongo, Patrizia
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders
2021 Tomassi, Stefano; Romanelli, Annalisa; Zwergel, Clemens; Valente, Sergio; Mai, Antonello
m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options
2021 Garbo, Sabrina; Zwergel, Clemens; Battistelli, Cecilia
Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity
2021 Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Conte, Mariarosaria; Nebbioso, Angela; Mazzone, Roberta; Brosch, Gerald; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Valente, Sergio; Mai, Antonello
The innovative potential of selenium-containing agents for fighting cancer and viral infections
2021 Ali, W.; Benedetti, R.; Handzlik, J.; Zwergel, C.; Battistelli, C.
Sex-dependent effects of the drugs of abuse amphetamine and the smart drug 3,4-methylenedioxypyrovalerone on fear memory generalization in rats
2021 Riccardi, Eleonora; Blasi, Eleonora; Zwergel, Clemens; Mai, Antonello; Morena, Maria; Campolongo, Patrizia
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction
2021 Du, Daohai; Xu, Dandan; Zhu, Licheng; Stazi, Giulia; Zwergel, Clemens; Liu, Yanli; Luo, Zhongyuan; Li, Yuanqing; Zhang, Yuanyuan; Zhu, Kongkai; Ding, Yiluan; Liu, Jingqiu; Fan, Shijie; Zhao, Kaiyan; Zhang, Naixia; Kong, Xiangqian; Jiang, Hualiang; Chen, Kaixian; Zhao, Kehao; Valente, Sergio; Min, Jinrong; Duan, Wenhu; Luo, Cheng
Editorial: chemical innovative approaches in cancer molecular medicine and translational clinical research
2020 Benedetti, Rosaria; Conte, Mariarosaria; Dell'Aversana, Carmela; Hansen, Finn K.; Zwergel, Clemens
The innovative potential of statins in cancer: new targets for new therapies
2020 Di Bello, Elisabetta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio
Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats
2020 Schiavi, Sara; Melancia, Francesca; Carbone, Emilia; Buzzelli, Valeria; Manduca, Antonia; Peinado, Patricia Jiménez; Zwergel, Clemens; Mai, Antonello; Campolongo, Patrizia; Vanderschuren, Louk J M J; Trezza, Viviana
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation
2020 Fioravanti, R.; Romanelli, A.; Mautone, N.; Di Bello, E.; Rovere, A.; Corinti, D.; Zwergel, C.; Valente, S.; Rotili, D.; Botrugno, O. A.; Dessanti, P.; Vultaggio, S.; Vianello, P.; Cappa, A.; Binda, C.; Mattevi, A.; Minucci, S.; Mercurio, C.; Varasi, M.; Mai, A.
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
2020 Mautone, Nicola; Zwergel, Clemens; Mai, Antonello; Rotili, Dante
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization
2020 Caroselli, Silvia; Zwergel, Clemens; Pirolli, Adele; Sabatino, Manuela; Xu, Zhanjie; Kirsch, Gilbert; Mai, Antonello; Colotti, Gianni; Altieri, Fabio; Canipari, Rita; Valente, Sergio; Ragno, Rino
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation
2020 Zwergel, C.; Fioravanti, R.; Stazi, G.; Sarno, F.; Battistelli, C.; Romanelli, A.; Nebbioso, A.; Mendes, E.; Paulo, A.; Strippoli, R.; Tripodi, M.; Pechalrieu, D.; Arimondo, P. B.; De Luca, T.; Del Bufalo, D.; Trisciuoglio, D.; Altucci, L.; Valente, S.; Mai, A.
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma
2020 Ali, Wesam; Spengler, Gabriella; Kincses, Annamária; Nové, Márta; Battistelli, Cecilia; Latacz, Gniewomir; Starek, Małgorzata; Dąbrowska, Monika; Honkisz-Orzechowska, Ewelina; Romanelli, Annalisa; Rasile, Manuela Monica; Szymańska, Ewa; Jacob, Claus; Zwergel, Clemens; Handzlik, Jadwiga
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells
2020 Romanelli, Annalisa; Stazi, Giulia; Fioravanti, Rossella; Zwergel, Clemens; Di Bello, Elisabetta; Pomella, Silvia; Perrone, Clara; Battistelli, Cecilia; Strippoli, Raffaele; Tripodi, Marco; del Bufalo, Donatella; Rota, Rossella; Trisciuoglio, Daniela; Mai, Antonello; Valente, Sergio
Sirtuins as drug targets
2019 Zwergel, Clemens; Rotili, Dante; Valente, Sergio; Mai, Antonello
Lysine methyltransferases and their inhibitors
2019 Stazi, Giulia; Zwergel, Clemens; Valente, Sergio
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
2019 Zwergel, Clemens; Schnekenburger, Michael; Sarno, Federica; Battistelli, Cecilia; Manara, Maria Cristina; Stazi, Giulia; Mazzone, Roberta; Fioravanti, Rossella; Gros, Christina; Ausseil, Frédéric; Florean, Cristina; Nebbioso, Angela; Strippoli, Raffaele; Ushijima, Toshikazu; Scotlandi, Katia; Tripodi, Marco; Arimondo, Paola B.; Altucci, Lucia; Diederich, Marc; Mai, Antonello; Valente, Sergio
Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat
2019 ATEHORTUA MARTINEZ, LUISA ALESSANDRA; Masniere, Cyriaque; Campolongo, Patrizia; Chasseigneaux, Stéphanie; Callebert, Jacques; Zwergel, Clemens; Mai, Antonello; Laplanche, Jean-Louis; Chen, Huixiong; Etheve-Quelquejeu, Mélanie; Mégarbane, Bruno; Benturquia, Nadia
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
2019 Stazi, Giulia; Battistelli, Cecilia; Piano, Valentina; Mazzone, Roberta; Marrocco, Biagina; Marchese, Sara; Louie, Sharon M.; Zwergel, Clemens; Antonini, Lorenzo; Patsilinakos, Alexandros; Ragno, Rino; Viviano, Monica; Sbardella, Gianluca; Ciogli, Alessia; Fabrizi, Giancarlo; Cirilli, Roberto; Strippoli, Raffaele; Marchetti, Alessandra; Tripodi, Marco; Nomura, Daniel K.; Mattevi, Andrea; Mai, Antonello; Valente, Sergio
Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs)
2019 Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello
The emerging role of epigenetics in human autoimmune disorders
2019 Mazzone, Roberta; Zwergel, Clemens; Artico, Marco; Taurone, Samanta; Ralli, Massimo; Greco, Antonio; Mai, Antonello
Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats
2019 Colucci, Paola; Mancini, Giulia Federica; Santori, Alessia; Zwergel, Clemens; Mai, Antonello; Trezza, Viviana; Roozendaal, Benno; Campolongo, Patrizia
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells
2018 Mellini, Paolo; Marrocco, Biagina; Borovika, Diana; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Stazi, Giulia; Zwergel, Clemens; Trapencieris, Peteris; Ferretti, Elisabetta; Tafani, Marco; Valente, Sergio; Mai, Antonello
Application of small epigenetic modulators in pediatric medulloblastoma
2018 Zwergel, Clemens; Romanelli, Annalisa; Stazi, Giulia; Besharat, Zein Mersini; Catanzaro, Giuseppina; Tafani, Marco; Valente, Sergio; Mai, Antonello
Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers
2018 Muñoz-Cobo, I.; Erburu, M. M.; Zwergel, C.; Cirilli, Raffaela; Mai, A.; Valente, S.; Puerta, E.; Tordera, Rosa M.
Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice
2018 Buonvicino, Daniela; Felici, Roberta; Ranieri, GIUSEPPE ANTONIO; Caramelli, Riccardo; Lapucci, Andrea; Cavone, Leonardo; Muzzi, Mirko; Di Pietro, Lorena; Bernardini, Camilla; Zwergel, Clemens; Valente, Sergio; Mai, Antonello; Chiarugi, Alberto
Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds
2018 Fioravanti, R; Stazi, G; Zwergel, C; Valente, S; Mai, A.
A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy
2018 Manara, Maria Cristina; Valente, Sergio; Cristalli, Camilla; Nicoletti, Giordano; Landuzzi, Lorena; Zwergel, Clemens; Mazzone, Roberta; Stazi, Giulia; Arimondo, Paola B.; Pasello, Michela; Guerzoni, Clara; Picci, Piero; Nanni, Patrizia; Lollini, Pier-Luigi; Mai, Antonello; Scotlandi, Katia
Trends of LSD1 inhibitors in viral infections
2018 Zwergel, Clemens; Stazi, Giulia; Mai, Antonello; Valente, Sergio
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal
2018 Rossi, Lucia; Battistelli, Cecilia; DE TURRIS, Valeria; Noce, Valeria; Zwergel, Clemens; Valente, Sergio; Moioli, Alessandra; Manzione, Andrea; Palladino, Marco; Bordoni, Veronica; Domenici, Alessandro; Mene', Paolo; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells
2017 Zwergel, Clemens; Czepukojc, Brigitte; Evain Bana, Emilie; Xu, Zhanjie; Stazi, Giulia; Mori, Mattia; Patsilinakos, Alexandros; Mai, Antonello; Botta, Bruno; Ragno, Rino; Bagrel, Denise; Kirsch, Gilbert; Meiser, Peter; Jacob, Claus; Montenarh, Mathias; Valente, Sergio
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
2017 Miele, Evelina; Valente, Sergio; Alfano, Vincenzo; Silvano, Marianna; Mellini, Paolo; Borovika, Diana; Marrocco, Biagina; Po, Agnese; Besharat, Zein Mersini; Catanzaro, Giuseppina; Battaglia, Giuseppe; Abballe, Luana; Zwergel, Clemens; Stazi, Giulia; Milite, Ciro; Castellano, Sabrina; Tafani, Marco; Trapencieris, Peteris; Mai, Antonello; Ferretti, Elisabetta
Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity
2017 Palanisamy, S. K.; Trisciuoglio, D.; Zwergel, C.; Del Bufalo, D.; Mai, A.
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
2017 Mazzone, Roberta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.
2017 Ourailidou, Me; Lenoci, A; Zwergel, Clemens; Rotili, Dante; Mai, Antonello; Dekker, F. j. 4.
EZH2 inhibitors: a patent review (2014-2016)
2017 Stazi, Giulia; Zwergel, Clemens; Mai, Antonello; Valente, Sergio
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice
2017 Lapucci, Andrea; Cavone, Leonardo; Buonvicino, Daniela; Felici, Roberta; Gerace, Elisabetta; Zwergel, Clemens; Valente, Sergio; Mai, Antonello; Chiarugi, Alberto
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model
2016 Di Liddo, Rosa; Valente, Sergio; Taurone, Samanta; Zwergel, Clemens; Marrocco, Biagina; Turchetta, Rosaria; Conconi, Maria Teresa; Scarpa, Carlotta; Bertalot, Thomas; Schrenk, Sandra; Mai, Antonello; Artico, Marco
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells
2016 Valente, Sergio; Mellini, Paolo; Spallotta, Francesco; Carafa, Vincenzo; Nebbioso, Angela; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Trisciuoglio, Daniela; Gabellini, Chiara; Tardugno, Maria; Zwergel, Clemens; Cencioni, Chiara; Atlante, Sandra; Moniot, Sébastien; Steegborn, Clemens; Budriesi, Roberta; Tafani, Marco; Del Bufalo, Donatella; Altucci, Lucia; Gaetano, Carlo; Mai, Antonello
DNA methyltransferases Inhibitors from natural sources
2016 Zwergel, Clemens; Valente, Sergio; Mai, Antonello
LSD1 inhibitors: a patent review (2010-2015)
2016 Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello
One-pot synthesis of benzopyran-4-ones with cancer preventive and therapeutic potential
2016 Talhi, Oualid; Brodziak Jarosz, Lidia; Panning, Jana; Orlikova, Barbora; Zwergel, Clemens; Tzanova, Tzvetomira; Philippot, Stéphanie; Pinto, Diana C. G. A.; Paz, Filipe A. Almeida; Gerhaüser, Clarissa; Dick, Tobias P.; Jacob, Claus; Diederich, Marc; Bagrel, Denyse; Kirsch, Gilbert; Silva, Artur M. S.
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation
2016 Panella, Simona; Marcocci, Maria Elena; Celestino, Ignacio; Valente, Sergio; Zwergel, Clemens; Li Puma, Domenica Donatella; Nencioni, Lucia; Mai, Antonello; Palamara, ANNA TERESA; Simonetti, Giovanna
Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas
2015 Manara, Maria Cristina; Valente, Sergio; Cristalli, Camilla; Baricordi, Cristina; Zwergel, Clemens; Arimondo, Paola B; Picci, Piero; Mai, Antonello; Scotlandi, Katia
Emerging approaches for histone deacetylase inhibitor drug discovery
2015 Zwergel, Clemens; Valente, Sergio; Jacob, Claus; Mai, Antonello
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells
2015 G., Di Pompo; M., Salerno; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; S., Avnet; G., Lattanzi; N., Baldini; Mai, Antonello
Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines
2014 C., Seidel; M., Schnekenburger; Zwergel, Clemens; F., Gaascht; Mai, Antonello; M., Dicato; G., Kirsch; Valente, Sergio; M., Diederich
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells
2014 Valente, Sergio; Yiwei, Liu; Michael, Schnekenburger; Zwergel, Clemens; Sandro, Cosconati; Christina, Gros; Maria, Tardugno; Donatella, Labella; Cristina, Florean; Steven, Minden; Hideharu, Hashimoto; Yanqi, Chang; Xing, Zhang; Gilbert, Kirsch; Ettore, Novellino; Paola B., Arimondo; Miele, Evelina; Ferretti, Elisabetta; Gulino, Alberto; Marc, Diederich; Xiaodong, Cheng; Mai, Antonello
Novel benzofuran-chromone and -coumarin derivatives: Synthesis and biological activity in K562 human leukemia cells
2013 Zwergel, Clemens; Valente, Sergio; Salvato, Angela; Xu, Zhanjie; Talhi, Oualid; Mai, Antonello; Silva, Artur; Altucci, Lucia; Kirsch, Gilbert
Reactivity of 4-vinyl-2H-1-benzopyran-2-ones in diels-alder cycloaddition reactions: Access to coumarin-based polycycles with Cdc25 phosphatase-inhibiting activity
2013 Valente, Sergio; Zhanjie, Xu; Emilie, Bana; Zwergel, Clemens; Mai, Antonello; Jacob, Claus; Peter, Meiser; Denyse, Bagrel; Artur M. S., Silva; Kirsch, Gilbert
Aurones: Interesting Natural and Synthetic Compounds with Emerging Biological Potential
2012 Zwergel, Clemens; F., Gaascht; Valente, Sergio; M., Diederich; D., Bagrel; G., Kirsch
Interactions of polysulfanes with components of red blood cells
2011 Schneider, Thomas; Ba, Lalla A.; Khairan, Khairan; Zwergel, Clemens; Bach, Nguyen Duc; Bernhardt, Ingolf; Brandt, Wolfgang; Wessjohann, Ludger; Diederich, Marc; Jacob, Claus
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype | 2024 | Trionfetti, Flavia; Montaldo, Claudia; Caiello, Ivan; Bontempi, Giulio; Terri, Michela; Tiberi, Marta; Marchant, Vanessa; Domenici, Alessandro; Menè, Paolo; Cordani, Marco; Zwergel, Clemens; Prencipe, Giusi; Ruiz-Ortega, Marta; Valente, Sergio; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele | |
| First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease | 2024 | Pyka, Patryk; Haberek, Wawrzyniec; Więcek, Małgorzata; Szymanska, Ewa; Ali, Wesam; Cios, Agnieszka; Jastrzębska-Więsek, Magdalena; Satała, Grzegorz; Podlewska, Sabina; Di Giacomo, Silvia; Di Sotto, Antonella; Garbo, Sabrina; Karcz, Tadeusz; Lambona, Chiara; Marocco, Francesco; Latacz, Gniewomir; Sudoł-Tałaj, Sylwia; Mordyl, Barbara; Głuch-Lutwin, Monika; Siwek, Agata; Czarnota-Łydka, Kinga; Gogola, Dawid; Olejarz-Maciej, Agnieszka; Wilczyńska-Zawal, Natalia; Honkisz-Orzechowska, Ewelina; Starek, Małgorzata; Dąbrowska, Monika; Kucwaj-Brysz, Katarzyna; Fioravanti, Rossella; Nasim, Muhammad Jawad; Hittinger, Marius; Partyka, Anna; Wesołowska, Anna; Battistelli, Cecilia; Zwergel, Clemens; Handzlik, Jadwiga | |
| HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling | 2024 | Terri, Michela; Sandoval, Pilar; Bontempi, Giulio; Montaldo, Claudia; Tomero-Sanz, Henar; de Turris, Valeria; Trionfetti, Flavia; Pascual-Antón, Lucía; Clares-Pedrero, Irene; Battistelli, Cecilia; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Rosanò, Laura; Del Pozo, Miguel Ángel; Sánchez-Álvarez, Miguel; Cabañas, Carlos; Tripodi, Marco; López-Cabrera, Manuel; Strippoli, Raffaele | |
| SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process | 2024 | Lambona, Chiara; Zwergel, Clemens; Valente, Sergio; Mai, Antonello | |
| Selenium-Containing Agents Acting on Cancer—A New Hope? | 2023 | Garbo, Sabrina; Di Giacomo, Silvia; Łażewska, Dorota; Honkisz-Orzechowska, Ewelina; Di Sotto, Antonella; Fioravanti, Rossella; Zwergel, Clemens; Battistelli, Cecilia | |
| PD-L1 small-molecule modulators: a new hope in epigenetic-based multidrug cancer therapy? | 2023 | Zwergel, Clemens; Fioravanti, Rossella; Mai, Antonello | |
| Editorial: Frontiers in Chemistry: rising stars 2022 | 2023 | Brites, Carlos D. S.; Contini, Daniele; He, Xiao-Peng; Liu, Tianqing; Moosa, Basem; Pannico, Marianna; Rashed, Mohamed Nageeb; Qiu, Yunping; Zwergel, Clemens | |
| GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design | 2023 | Castiello, Carola; Junghanns, Pierre; Mergel, Annika; Jacob, Claus; Ducho, Christian; Valente, Sergio; Rotili, Dante; Fioravanti, Rossella; Zwergel, Clemens; Mai, Antonello | |
| HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells | 2023 | Trionfetti, Flavia; Alonzi, Tonino; Bontempi, Giulio; Terri, Michela; Battistelli, Cecilia; Montaldo, Claudia; Repele, Federica; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; Matusali, Giulia; Maggi, Fabrizio; Goletti, Delia; Tripodi, Marco; Mai, Antonello; Strippoli, Raffaele | |
| Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells | 2023 | Di Bello, Elisabetta; Sian, Veronica; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Tomassi, Stefano; Corinti, Davide; Passeri, Daniela; Pellicciari, Roberto; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Tripodi, Marco; Strippoli, Raffaele; Nebbioso, Angela; Valente, Sergio; Mai, Antonello | |
| Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells | 2023 | Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; DI BELLO, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello | |
| Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors | 2023 | Lambona, Chiara; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Mai, Antonello | |
| Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages | 2023 | Noce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Masotti, Andrea; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Chakrabarti, Alokta; Romier, Christophe; Robaa, Dina; Sippl, Wolfgang; Jung, Manfred; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello | |
| Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity | 2022 | Fioravanti, Rossella; Rodriguez, Veronica; Caroli, Jonatan; Chianese, Ugo; Benedetti, Rosaria; Di Bello, Elisabetta; Noce, Beatrice; Zwergel, Clemens; Corinti, Davide; Viña, Dolores; Altucci, Lucia; Mattevi, Andrea; Valente, Sergio; Mai, Antonello | |
| Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 | 2022 | Suenkel, Benjamin; Valente, Sergio; Zwergel, Clemens; Weiss, Sandra; DI BELLO, Elisabetta; Fioravanti, Rossella; Aventaggiato, Michele; Amorim, João A.; Garg, Neha; Kumar, Surinder; Lombard, David B.; Hu, Tuo; Singh, Pankaj K.; Tafani, Marco; Palmeira, Carlos M.; Sinclair, David; Mai, Antonello; Steegborn, Clemens | |
| Editorial: Multi-target directed ligands for the treatment of cancer | 2022 | Brindisi, Margherita; Kessler, Sonja M.; Kumar, Vinod; Zwergel, Clemens | |
| Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni | 2022 | Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Fianco, Giulia; Trisciuoglio, Daniela; Mourão, Marina M; Sales, Policarpo; Lamotte, Suzanne; Prina, Eric; Späth, Gerald F; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello | |
| Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma | 2022 | Ali, Wesam; Garbo, Sabrina; Kincses, Annamária; Nové, Márta; Spengler, Gabriella; Di Bello, Elisabetta; Honkisz-Orzechowska, Ewelina; Karcz, Tadeusz; Szymańska, Ewa; Żesławska, Ewa; Starek, Małgorzata; Dąbrowska, Monika; Nitek, Wojciech; Kucwaj-Brysz, Katarzyna; Pyka, Patryk; Fioravanti, Rossella; Jacob, Claus; Battistelli, Cecilia; Zwergel, Clemens; Handzlik, Jadwiga | |
| Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells | 2022 | Bontempi, Giulio; Terri, Michela; Garbo, Sabrina; Montaldo, Claudia; Mariotti, Davide; Bordoni, Veronica; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Marchetti, Alessandra; Domenici, Alessandro; Menè, Paolo; Battistelli, Cecilia; Tripodi, Marco; Strippoli, Raffaele | |
| Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy | 2022 | Morroni, Jacopo; Schirone, Leonardo; Valenti, Valentina; Zwergel, Clemens; Riera, Carles Sánchez; Valente, Sergio; Vecchio, Daniele; Schiavon, Sonia; Ragno, Rino; Mai, Antonello; Sciarretta, Sebastiano; Lozanoska-Ochser, Biliana; Bouchè, Marina | |
| Sirtuins | 2021 | Zwergel, Clemens; Tomaselli, Daniela; Mai, Antonello | |
| Amphetamine modulation of long-term object recognition memory in rats: influence of stress | 2021 | Colucci, Paola; Santori, Alessia; Romanelli, Luca; Zwergel, Clemens; Mai, Antonello; Scaccianoce, Sergio; Campolongo, Patrizia | |
| Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders | 2021 | Tomassi, Stefano; Romanelli, Annalisa; Zwergel, Clemens; Valente, Sergio; Mai, Antonello | |
| m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options | 2021 | Garbo, Sabrina; Zwergel, Clemens; Battistelli, Cecilia | |
| Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity | 2021 | Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Conte, Mariarosaria; Nebbioso, Angela; Mazzone, Roberta; Brosch, Gerald; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Valente, Sergio; Mai, Antonello | |
| The innovative potential of selenium-containing agents for fighting cancer and viral infections | 2021 | Ali, W.; Benedetti, R.; Handzlik, J.; Zwergel, C.; Battistelli, C. | |
| Sex-dependent effects of the drugs of abuse amphetamine and the smart drug 3,4-methylenedioxypyrovalerone on fear memory generalization in rats | 2021 | Riccardi, Eleonora; Blasi, Eleonora; Zwergel, Clemens; Mai, Antonello; Morena, Maria; Campolongo, Patrizia | |
| Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction | 2021 | Du, Daohai; Xu, Dandan; Zhu, Licheng; Stazi, Giulia; Zwergel, Clemens; Liu, Yanli; Luo, Zhongyuan; Li, Yuanqing; Zhang, Yuanyuan; Zhu, Kongkai; Ding, Yiluan; Liu, Jingqiu; Fan, Shijie; Zhao, Kaiyan; Zhang, Naixia; Kong, Xiangqian; Jiang, Hualiang; Chen, Kaixian; Zhao, Kehao; Valente, Sergio; Min, Jinrong; Duan, Wenhu; Luo, Cheng | |
| Editorial: chemical innovative approaches in cancer molecular medicine and translational clinical research | 2020 | Benedetti, Rosaria; Conte, Mariarosaria; Dell'Aversana, Carmela; Hansen, Finn K.; Zwergel, Clemens | |
| The innovative potential of statins in cancer: new targets for new therapies | 2020 | Di Bello, Elisabetta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio | |
| Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats | 2020 | Schiavi, Sara; Melancia, Francesca; Carbone, Emilia; Buzzelli, Valeria; Manduca, Antonia; Peinado, Patricia Jiménez; Zwergel, Clemens; Mai, Antonello; Campolongo, Patrizia; Vanderschuren, Louk J M J; Trezza, Viviana | |
| Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation | 2020 | Fioravanti, R.; Romanelli, A.; Mautone, N.; Di Bello, E.; Rovere, A.; Corinti, D.; Zwergel, C.; Valente, S.; Rotili, D.; Botrugno, O. A.; Dessanti, P.; Vultaggio, S.; Vianello, P.; Cappa, A.; Binda, C.; Mattevi, A.; Minucci, S.; Mercurio, C.; Varasi, M.; Mai, A. | |
| Sirtuin modulators: where are we now? A review of patents from 2015 to 2019 | 2020 | Mautone, Nicola; Zwergel, Clemens; Mai, Antonello; Rotili, Dante | |
| Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization | 2020 | Caroselli, Silvia; Zwergel, Clemens; Pirolli, Adele; Sabatino, Manuela; Xu, Zhanjie; Kirsch, Gilbert; Mai, Antonello; Colotti, Gianni; Altieri, Fabio; Canipari, Rita; Valente, Sergio; Ragno, Rino | |
| Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation | 2020 | Zwergel, C.; Fioravanti, R.; Stazi, G.; Sarno, F.; Battistelli, C.; Romanelli, A.; Nebbioso, A.; Mendes, E.; Paulo, A.; Strippoli, R.; Tripodi, M.; Pechalrieu, D.; Arimondo, P. B.; De Luca, T.; Del Bufalo, D.; Trisciuoglio, D.; Altucci, L.; Valente, S.; Mai, A. | |
| Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma | 2020 | Ali, Wesam; Spengler, Gabriella; Kincses, Annamária; Nové, Márta; Battistelli, Cecilia; Latacz, Gniewomir; Starek, Małgorzata; Dąbrowska, Monika; Honkisz-Orzechowska, Ewelina; Romanelli, Annalisa; Rasile, Manuela Monica; Szymańska, Ewa; Jacob, Claus; Zwergel, Clemens; Handzlik, Jadwiga | |
| Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells | 2020 | Romanelli, Annalisa; Stazi, Giulia; Fioravanti, Rossella; Zwergel, Clemens; Di Bello, Elisabetta; Pomella, Silvia; Perrone, Clara; Battistelli, Cecilia; Strippoli, Raffaele; Tripodi, Marco; del Bufalo, Donatella; Rota, Rossella; Trisciuoglio, Daniela; Mai, Antonello; Valente, Sergio | |
| Sirtuins as drug targets | 2019 | Zwergel, Clemens; Rotili, Dante; Valente, Sergio; Mai, Antonello | |
| Lysine methyltransferases and their inhibitors | 2019 | Stazi, Giulia; Zwergel, Clemens; Valente, Sergio | |
| Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells | 2019 | Zwergel, Clemens; Schnekenburger, Michael; Sarno, Federica; Battistelli, Cecilia; Manara, Maria Cristina; Stazi, Giulia; Mazzone, Roberta; Fioravanti, Rossella; Gros, Christina; Ausseil, Frédéric; Florean, Cristina; Nebbioso, Angela; Strippoli, Raffaele; Ushijima, Toshikazu; Scotlandi, Katia; Tripodi, Marco; Arimondo, Paola B.; Altucci, Lucia; Diederich, Marc; Mai, Antonello; Valente, Sergio | |
| Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat | 2019 | ATEHORTUA MARTINEZ, LUISA ALESSANDRA; Masniere, Cyriaque; Campolongo, Patrizia; Chasseigneaux, Stéphanie; Callebert, Jacques; Zwergel, Clemens; Mai, Antonello; Laplanche, Jean-Louis; Chen, Huixiong; Etheve-Quelquejeu, Mélanie; Mégarbane, Bruno; Benturquia, Nadia | |
| Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells | 2019 | Stazi, Giulia; Battistelli, Cecilia; Piano, Valentina; Mazzone, Roberta; Marrocco, Biagina; Marchese, Sara; Louie, Sharon M.; Zwergel, Clemens; Antonini, Lorenzo; Patsilinakos, Alexandros; Ragno, Rino; Viviano, Monica; Sbardella, Gianluca; Ciogli, Alessia; Fabrizi, Giancarlo; Cirilli, Roberto; Strippoli, Raffaele; Marchetti, Alessandra; Tripodi, Marco; Nomura, Daniel K.; Mattevi, Andrea; Mai, Antonello; Valente, Sergio | |
| Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs) | 2019 | Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello | |
| The emerging role of epigenetics in human autoimmune disorders | 2019 | Mazzone, Roberta; Zwergel, Clemens; Artico, Marco; Taurone, Samanta; Ralli, Massimo; Greco, Antonio; Mai, Antonello | |
| Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats | 2019 | Colucci, Paola; Mancini, Giulia Federica; Santori, Alessia; Zwergel, Clemens; Mai, Antonello; Trezza, Viviana; Roozendaal, Benno; Campolongo, Patrizia | |
| Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells | 2018 | Mellini, Paolo; Marrocco, Biagina; Borovika, Diana; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Stazi, Giulia; Zwergel, Clemens; Trapencieris, Peteris; Ferretti, Elisabetta; Tafani, Marco; Valente, Sergio; Mai, Antonello | |
| Application of small epigenetic modulators in pediatric medulloblastoma | 2018 | Zwergel, Clemens; Romanelli, Annalisa; Stazi, Giulia; Besharat, Zein Mersini; Catanzaro, Giuseppina; Tafani, Marco; Valente, Sergio; Mai, Antonello | |
| Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers | 2018 | Muñoz-Cobo, I.; Erburu, M. M.; Zwergel, C.; Cirilli, Raffaela; Mai, A.; Valente, S.; Puerta, E.; Tordera, Rosa M. | |
| Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice | 2018 | Buonvicino, Daniela; Felici, Roberta; Ranieri, GIUSEPPE ANTONIO; Caramelli, Riccardo; Lapucci, Andrea; Cavone, Leonardo; Muzzi, Mirko; Di Pietro, Lorena; Bernardini, Camilla; Zwergel, Clemens; Valente, Sergio; Mai, Antonello; Chiarugi, Alberto | |
| Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds | 2018 | Fioravanti, R; Stazi, G; Zwergel, C; Valente, S; Mai, A. | |
| A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy | 2018 | Manara, Maria Cristina; Valente, Sergio; Cristalli, Camilla; Nicoletti, Giordano; Landuzzi, Lorena; Zwergel, Clemens; Mazzone, Roberta; Stazi, Giulia; Arimondo, Paola B.; Pasello, Michela; Guerzoni, Clara; Picci, Piero; Nanni, Patrizia; Lollini, Pier-Luigi; Mai, Antonello; Scotlandi, Katia | |
| Trends of LSD1 inhibitors in viral infections | 2018 | Zwergel, Clemens; Stazi, Giulia; Mai, Antonello; Valente, Sergio | |
| HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal | 2018 | Rossi, Lucia; Battistelli, Cecilia; DE TURRIS, Valeria; Noce, Valeria; Zwergel, Clemens; Valente, Sergio; Moioli, Alessandra; Manzione, Andrea; Palladino, Marco; Bordoni, Veronica; Domenici, Alessandro; Mene', Paolo; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele | |
| Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells | 2017 | Zwergel, Clemens; Czepukojc, Brigitte; Evain Bana, Emilie; Xu, Zhanjie; Stazi, Giulia; Mori, Mattia; Patsilinakos, Alexandros; Mai, Antonello; Botta, Bruno; Ragno, Rino; Bagrel, Denise; Kirsch, Gilbert; Meiser, Peter; Jacob, Claus; Montenarh, Mathias; Valente, Sergio | |
| The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells | 2017 | Miele, Evelina; Valente, Sergio; Alfano, Vincenzo; Silvano, Marianna; Mellini, Paolo; Borovika, Diana; Marrocco, Biagina; Po, Agnese; Besharat, Zein Mersini; Catanzaro, Giuseppina; Battaglia, Giuseppe; Abballe, Luana; Zwergel, Clemens; Stazi, Giulia; Milite, Ciro; Castellano, Sabrina; Tafani, Marco; Trapencieris, Peteris; Mai, Antonello; Ferretti, Elisabetta | |
| Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity | 2017 | Palanisamy, S. K.; Trisciuoglio, D.; Zwergel, C.; Del Bufalo, D.; Mai, A. | |
| Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy | 2017 | Mazzone, Roberta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio | |
| Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity. | 2017 | Ourailidou, Me; Lenoci, A; Zwergel, Clemens; Rotili, Dante; Mai, Antonello; Dekker, F. j. 4. | |
| EZH2 inhibitors: a patent review (2014-2016) | 2017 | Stazi, Giulia; Zwergel, Clemens; Mai, Antonello; Valente, Sergio | |
| Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice | 2017 | Lapucci, Andrea; Cavone, Leonardo; Buonvicino, Daniela; Felici, Roberta; Gerace, Elisabetta; Zwergel, Clemens; Valente, Sergio; Mai, Antonello; Chiarugi, Alberto | |
| Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model | 2016 | Di Liddo, Rosa; Valente, Sergio; Taurone, Samanta; Zwergel, Clemens; Marrocco, Biagina; Turchetta, Rosaria; Conconi, Maria Teresa; Scarpa, Carlotta; Bertalot, Thomas; Schrenk, Sandra; Mai, Antonello; Artico, Marco | |
| 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells | 2016 | Valente, Sergio; Mellini, Paolo; Spallotta, Francesco; Carafa, Vincenzo; Nebbioso, Angela; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Trisciuoglio, Daniela; Gabellini, Chiara; Tardugno, Maria; Zwergel, Clemens; Cencioni, Chiara; Atlante, Sandra; Moniot, Sébastien; Steegborn, Clemens; Budriesi, Roberta; Tafani, Marco; Del Bufalo, Donatella; Altucci, Lucia; Gaetano, Carlo; Mai, Antonello | |
| DNA methyltransferases Inhibitors from natural sources | 2016 | Zwergel, Clemens; Valente, Sergio; Mai, Antonello | |
| LSD1 inhibitors: a patent review (2010-2015) | 2016 | Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello | |
| One-pot synthesis of benzopyran-4-ones with cancer preventive and therapeutic potential | 2016 | Talhi, Oualid; Brodziak Jarosz, Lidia; Panning, Jana; Orlikova, Barbora; Zwergel, Clemens; Tzanova, Tzvetomira; Philippot, Stéphanie; Pinto, Diana C. G. A.; Paz, Filipe A. Almeida; Gerhaüser, Clarissa; Dick, Tobias P.; Jacob, Claus; Diederich, Marc; Bagrel, Denyse; Kirsch, Gilbert; Silva, Artur M. S. | |
| MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation | 2016 | Panella, Simona; Marcocci, Maria Elena; Celestino, Ignacio; Valente, Sergio; Zwergel, Clemens; Li Puma, Domenica Donatella; Nencioni, Lucia; Mai, Antonello; Palamara, ANNA TERESA; Simonetti, Giovanna | |
| Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas | 2015 | Manara, Maria Cristina; Valente, Sergio; Cristalli, Camilla; Baricordi, Cristina; Zwergel, Clemens; Arimondo, Paola B; Picci, Piero; Mai, Antonello; Scotlandi, Katia | |
| Emerging approaches for histone deacetylase inhibitor drug discovery | 2015 | Zwergel, Clemens; Valente, Sergio; Jacob, Claus; Mai, Antonello | |
| Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells | 2015 | G., Di Pompo; M., Salerno; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; S., Avnet; G., Lattanzi; N., Baldini; Mai, Antonello | |
| Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines | 2014 | C., Seidel; M., Schnekenburger; Zwergel, Clemens; F., Gaascht; Mai, Antonello; M., Dicato; G., Kirsch; Valente, Sergio; M., Diederich | |
| Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells | 2014 | Valente, Sergio; Yiwei, Liu; Michael, Schnekenburger; Zwergel, Clemens; Sandro, Cosconati; Christina, Gros; Maria, Tardugno; Donatella, Labella; Cristina, Florean; Steven, Minden; Hideharu, Hashimoto; Yanqi, Chang; Xing, Zhang; Gilbert, Kirsch; Ettore, Novellino; Paola B., Arimondo; Miele, Evelina; Ferretti, Elisabetta; Gulino, Alberto; Marc, Diederich; Xiaodong, Cheng; Mai, Antonello | |
| Novel benzofuran-chromone and -coumarin derivatives: Synthesis and biological activity in K562 human leukemia cells | 2013 | Zwergel, Clemens; Valente, Sergio; Salvato, Angela; Xu, Zhanjie; Talhi, Oualid; Mai, Antonello; Silva, Artur; Altucci, Lucia; Kirsch, Gilbert | |
| Reactivity of 4-vinyl-2H-1-benzopyran-2-ones in diels-alder cycloaddition reactions: Access to coumarin-based polycycles with Cdc25 phosphatase-inhibiting activity | 2013 | Valente, Sergio; Zhanjie, Xu; Emilie, Bana; Zwergel, Clemens; Mai, Antonello; Jacob, Claus; Peter, Meiser; Denyse, Bagrel; Artur M. S., Silva; Kirsch, Gilbert | |
| Aurones: Interesting Natural and Synthetic Compounds with Emerging Biological Potential | 2012 | Zwergel, Clemens; F., Gaascht; Valente, Sergio; M., Diederich; D., Bagrel; G., Kirsch | |
| Interactions of polysulfanes with components of red blood cells | 2011 | Schneider, Thomas; Ba, Lalla A.; Khairan, Khairan; Zwergel, Clemens; Bach, Nguyen Duc; Bernhardt, Ingolf; Brandt, Wolfgang; Wessjohann, Ludger; Diederich, Marc; Jacob, Claus |
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